Carbon-X vs Laguna S 2.1

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Laguna S 2.1

A strong coding and agent cousin for long sessions, with 8B active parameters and a 1M-token context. At 4-bit it needs a 96 to 128 GB machine, tight on a 128 GB one. The main risks are that nobody at Poolside answers its many reports, there are no safety results, and a build card misdescribes its file.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Laguna S 2.1

1. Quickest start is ollama run laguna-s-2.1, 96 GB for the default Q4_K_M, or the 66 GB nvfp4 tag on Apple Silicon
2. On our reference machine try llama-server -hf poolside/Laguna-S-2.1-GGUF:Q4_K_M --jinja -c 65536, from a llama.cpp release with the laguna architecture (b11772 has it). The 96 GB file leaves little room for context in 107.4 GB
3. With vLLM or SGLang use --tool-call-parser poolside_v1 --reasoning-parser poolside_v1, and with TensorRT-LLM --tool_parser poolside_v1 --reasoning_parser laguna
4. Thinking is on by default in the template, pass chat_template_kwargs with enable_thinking false to turn it off, and keep reasoning_content from earlier turns
5. The GGUFs ship set to 262,144 tokens. For 1M with llama.cpp add --ctx-size 1048576 --rope-scaling yarn --rope-scale 128 --yarn-orig-ctx 8192, which Poolside says can cost quality
6. Sampling per the generation config is temperature 1.0 and top_k 20, and Poolside suggests temperature 0.7 and top_p 0.95 at 1M
7. Expect occasional tool-schema slips in harnesses unlike Poolside's own, and validate JSON arguments, which Poolside lists as known limitations