Carbon-X vs Nanbeige4.3-33B

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Nanbeige4.3-33B

A dense 33B Llama-architecture cousin for long agentic coding and office tasks, with per-request thinking, XML tool calls that stock vLLM and SGLang parse, and 512K of context. It needs about 96 GB at BF16, as Nanbeige ships no quantised build. Its agentic results so far are Nanbeige's own, with no safety results, training data notes or licence file.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Nanbeige4.3-33B

1. Serve with vllm serve Nanbeige/Nanbeige4.3-33B --enable-auto-tool-choice --reasoning-parser qwen3 --tool-call-parser qwen3_coder, as the card says, or SGLang with the same two parsers
2. Keep tool_call_format at its default xml, since qwen3_coder parses that format; the json option writes Hermes-style JSON calls, which need a different parser such as vLLM's hermes
3. Pass chat_template_kwargs {"preserve_thinking": true} for multi-turn tool use and coding, and {"enable_thinking": false} to skip reasoning, as the card recommends
4. Use temperature 1.0, top_p 0.95 and up to 65,536 new tokens for agent work, and temperature 0.6 for reasoning and chat, per the card
5. Send your own system prompt, since without one the template injects a Chinese identity line, or a Chinese tool-expert prompt when tools are passed
6. Send one system message at the start only, as the template raises an error for a later one
7. In plain Transformers pass use_cache=True to generate, since config.json and generation_config.json set it false; trust_remote_code isn't needed