Carbon-X vs Gemma 4 26B A4B IT

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Gemma 4 26B A4B IT

A fast mixture-of-experts cousin for general agent work with tools, optional thinking and image input, under Apache 2.0. Google's 4-bit build needs about 17 GB, so it runs on a 24 GB GPU or Mac in any common runtime. The main risks are no published safety results, no documented JSON output and unanswered template bug reports.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Gemma 4 26B A4B IT

1. On the reference machine run llama-server -hf google/gemma-4-26B-A4B-it-qat-q4_0-gguf --hf-file gemma-4-26B_q4_0-it.gguf --jinja -c 65536, and add the mmproj file for images
2. With Ollama run ollama run gemma4:26b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since Google's guide says it defaults to 4K below 24 GiB of VRAM and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Validate tool names and arguments before running them, and check any JSON yourself