Carbon-X vs LBS-27B

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

LBS-27B

A 27B Qwen3.8 fine-tune for GUI grounding that zooms into screenshots over a few turns before naming a point, and inclusionAI says it also helps with fine detail in large images. It needs about 96 GB at BF16 and a client that runs its crop actions. Every result so far is inclusionAI's own, with no safety results or injection guidance.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

LBS-27B

1. Serve with vllm serve inclusionAI/LBS-27B --tensor-parallel-size 4 --max-model-len 65536, which is what the card's wrapper script runs; keep the context at 32,768 or more for multi-turn images
2. Build the system prompt with build_system_prompt from the LBS branch's zoomin_grounding_protocol.py, send the screenshot after image_path: <name>, and don't pass tools; the model answers in plain text
3. Parse <action>crop_image(image_path=..., x1=..., y1=..., x2=..., y2=...)</action>, cut the crop yourself and return it with its mapping to the original image; allow at most two crops per turn and three per episode
4. Read the final answer as [x.xx,y.yy] on a 0 to 1000 scale of the original image, and use your own executor to click
5. Pass reasoning_effort as xhigh, medium or low only, since the template raises an error for high, and don't count on thinking_budget, which the template ignores
6. Don't turn on MTP speculative decoding; the MTP weights aren't in the repository though config.json names one MTP layer