Carbon-X vs GLM-4.5-Air

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

GLM-4.5-Air

An English and Chinese cousin for agent, coding and tool-calling work, with switchable thinking and wide runtime support. It needs about 135 GB for Z.ai's FP8 build, two to four H100s by Z.ai's figures, and Z.ai and Novita host it. The main risk is age, with files from August 2025 and no answers from Z.ai since.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

GLM-4.5-Air

1. Z.ai's FP8 recipe is python3 -m sglang.launch_server --model-path zai-org/GLM-4.5-Air-FP8 --tp-size 4 --tool-call-parser glm45 --reasoning-parser glm45, and 2 H100s are enough below the full 128K context
2. Use the glm45 tool and reasoning parsers for this model, the glm47 parser in Z.ai's current README is for GLM-4.7
3. Thinking is on by default, pass chat_template_kwargs with enable_thinking false for short tasks, which makes the template add /nothink and an empty think block
4. Declare tools in OpenAI style, and the template renders arguments as arg_key and arg_value pairs that the parser turns back into JSON
5. Keep prompts under 128,000 tokens, the tokenizer config's limit, though config.json allows 131,072
6. Validate JSON output yourself or use the runtime's guided decoding, since structured output isn't documented for the weights