Carbon-X vs Laguna XS 2.1

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Laguna XS 2.1

A small coding and agent cousin with 3B active parameters, so it's quick on modest hardware. Poolside's 4-bit GGUF, also Ollama's default, needs about 24 GB, and every major runtime runs it. The main risks are that nobody at Poolside answers its discussions, there are no safety results, and the SGLang route runs repository code.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Laguna XS 2.1

1. Quickest start is ollama run laguna-xs-2.1, 20 GB of files, the same Q4_K_M as Poolside's GGUF
2. On our reference machine use llama-server -hf poolside/Laguna-XS-2.1-GGUF:Q4_K_M --jinja -c 131072, from a llama.cpp release with the laguna architecture (b11772 has it), or BF16 with vLLM (66.9 GB)
3. With vLLM use --tool-call-parser poolside_v1 --reasoning-parser poolside_v1 --enable-auto-tool-choice, on a build with vllm-project/vllm#47311, or --tool-call-parser glm47 on older builds
4. Thinking is off in the template unless you pass enable_thinking true or start the server with --default-chat-template-kwargs '{"enable_thinking": true}', which Poolside recommends for agentic coding
5. Pass earlier reasoning back as reasoning_content in the history, since the card says reasoning may stop in later steps if it's dropped
6. Sampling per the card is temperature 1.0 and top_k 20
7. The card warns that Ollama on Apple Silicon may return empty output until llama.cpp#25389 ships
8. Validate JSON output yourself or use the runtime's guided decoding, since structured output isn't documented