Carbon-X vs DiffusionGemma 26B A4B IT

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

DiffusionGemma 26B A4B IT

A fast local generation cousin for low-concurrency work on text, images and video, with optional thinking and Gemma 4's tool format, under Apache 2.0. It needs about 62 GB for Google's BF16 files and runs only in Transformers or SGLang. The main risk is quality, since Google's own figures put it below Gemma 4 26B A4B, and it's labelled experimental.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

DiffusionGemma 26B A4B IT

1. Serve it with sglang serve --model-path google/diffusiongemma-26B-A4B-it --dllm-algorithm Gemma4Renoise --trust-remote-code on SGLang v0.5.22 or later, then call /v1/chat/completions
2. In Transformers, install transformers>=5.11.0 and load DiffusionGemmaForBlockDiffusion with dtype="auto"; generation_config.json already holds the recommended sampler
3. Turn thinking on with enable_thinking=True in apply_chat_template or <|think|> at the start of the system prompt, read the reasoning between <|channel>thought and <channel|>, and drop it from history before the next turn
4. Don't rely on temperature, top_p, logit_bias or JSON Schema in SGLang, which ignores or rejects them for this model; validate JSON yourself
5. Streaming arrives one 256-token canvas at a time, not token by token
6. Put images before text in the prompt, and pick an image token budget of 70 to 1,120 by how much detail the task needs