Carbon-X vs InternVL3.5-GPT-OSS-20B-A4B-Preview

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

InternVL3.5-GPT-OSS-20B-A4B-Preview

An image and video reader on gpt-oss-20b with an optional thinking mode, a preview untouched for over a year. It needs about 51 GB in BF16, since OpenGVLab publishes no quantised build, and runs in Transformers and vLLM. The main risk is a chat template in the Transformers-format repository that doesn't match its tokenizer, with no safety results.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

InternVL3.5-GPT-OSS-20B-A4B-Preview

1. Serve with vllm serve OpenGVLab/InternVL3_5-GPT-OSS-20B-A4B-Preview-HF --max-model-len 32768, which is our command; the card gives none for vLLM
2. Check the rendered prompt before relying on it, since the shipped template's <|im_start|> markers aren't tokens in the gpt-oss tokenizer; the GitHub-format repository's harmony template is the alternative
3. Use Transformers 4.55.0 or later, as the card requires for this size
4. For thinking, send the card's thinking system prompt and parse the reasoning out of the <think> tags, with temperature 0.6 and sampling on as the card advises
5. Keep inputs within 32K tokens, the length it was trained at, whatever the config says