Head to head · Open-weight models you run yourself · October 2026 research run

Carbon-X vs ZAYA1-8B

Carbon-X and ZAYA1-8B score within a point of each other on agent readiness, 61 (C) and 61 (C). ZAYA1-8B leads on agent interface. Both do open-weight models you run yourself.

Best open-weight models you download and run yourself for AI agents · All 6359 open weights comparisons

Which one, for what

Carbon-X C

Best for Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on

  • Reach, 90 against 80
  • Risk, 65 against 55
  • Documentation and upkeep, 72 against 50

Watch for

Not clinically validated and no wet-lab validation reported

ZAYA1-8B C

Best for People who want a small, fast reasoning model for maths and code and can live without tool calling

Ahead on

  • Agent interface, 60 against 35

Watch for

Tool calling needs a parser that only Zyphra's vLLM fork has

Why the edge

Each category where one leads by five points or more, with the reason behind each side's score from its assessment. The numbers are in the table below; this is what they stand for.

Agent interface ZAYA1-8B +25

Carbon-X 35

Chat template 20, a Jinja file in the repository. Tool-calling format 10, only the inherited template shows the format and no parser is named. Trained tool calling 0, nothing says it was trained to call tools. Structured output 0, not documented. Reasoning control 0, thinking can be switched off but was never trained, and the card asks you to keep it off. Context 5, 40,960 tokens from the base, though Hugging Face trained at 8,192 and under 16K. Most of what the card documents for agents is Carbon-X as a tool another model calls, which this checklist doesn't read.

ZAYA1-8B 60

Chat template 20, chat_template.jinja in the repository (10,700 characters). Tool-calling format 10, only the template and a fork say it. Trained tool calling 10, the template takes tools and renders calls, and the card recommends settings for agent use, but it doesn't say the model was trained for tool calling or for several calls in a turn, so the lower band. Structured output 0, Nothing on the card about JSON or schema-constrained output. Reasoning control 10, the template has an enable_thinking switch, and the card names the qwen3 reasoning parser, which returns the reasoning apart from the answer. Context 10, 131,072 positions in config.json, for an architecture Zyphra trained end to end, so the config is the model's own. 20 + 10 + 10 + 0 + 10 + 10 = 60.

Documentation and upkeep Carbon-X +22

Carbon-X 72

Model card 17, everything but a knowledge cut-off. Training data 15, the mid-training sources and shares are listed, the instruction and fine-tuning data aren't named, and there's no cut-off. Last change 20, 28 October 2026, when config.json, generation_config.json, tokenizer_config.json and tokenizer.py were fixed. Responsiveness 10, organisation members replied to 2 of the 4 questions so far. Version policy 5, a first release whose history was squashed without a note. File health 5, the card now sends llama.cpp users to the publisher's GGUF repository, but the tokenizer config's 131,072 still contradicts the card's 40,960. 17 + 15 + 20 + 10 + 5 + 5 = 72.

ZAYA1-8B 50

Model card 5, Intended use and the parameter counts are on the card. Training data 0, Nothing on the card about the training data. Last change 10, the main repository last changed on 26 June 2026 (the checkpoint reshaped for Transformers), 137 days before this check, and the quantised repositories on 2 July, 131 days. Responsiveness 20, Of the 16 most recent discussions that aren't pull requests (7 May to 14 August 2026), 10 have a reply from a Zyphra member, which is most. Version policy 5, the original checkpoint is kept as ZAYA1-8B-legacy and the card says so at the top, without a date. File health 10, Config, template and card agree on the architecture after the reshape. 5 + 0 + 10 + 20 + 5 + 10 = 50.

Reach Carbon-X +10

Carbon-X 90

Memory 30, the publisher's Q4_K_M GGUF is 9.6 GB, or 11.6 GB with a fifth added. Runtimes 20, released llama.cpp (from b11742, which added the DNA tokenizer), vLLM, SGLang and Transformers all run it, with no Ollama or LM Studio entry. Builds 15, Hugging Face publishes GGUFs at four precisions. Terms 15, Apache 2.0 on the model and on its Qwen3-14B base. Download 10, nothing is gated. Hosted 0, no inference provider or Hugging Face API serves it.

ZAYA1-8B 80

Memory 30, the smallest build from Zyphra is the MXFP4-Experts repository, 5.85 GB, and 5.85 GB × 1.2 = 7.0 GB, within 16 GB. Runtimes 10, Released Transformers 5.22.2 has the zaya model and SGLang 0.5.23 has srt/models/zaya.py. Builds 15, Quantised builds from Zyphra at two precisions, FP8 and MXFP4 for the experts, each in its own repository. Terms 15, Apache 2.0 in the card's metadata, an OSI licence with nothing added. Download 10, the Hub API reports gated false for the model and its builds on 10 November 2026, so the files download with no account and nothing to accept. Hosted 0, Hugging Face maps no inference provider to it, and the card names no API. Zyphra's site lists a cloud product for its open models, which wasn't checked for this model. 30 + 10 + 15 + 15 + 10 + 0 = 80.

Risk Carbon-X +10

Carbon-X 65

File safety 15, safetensors and GGUF only, but the documented loading path runs the repository's tokenizer.py through trust_remote_code. Provenance 15, the files are in HuggingFaceBio, which Hugging Face's GitHub repository links, with a checksum on every file. Safety evaluation 10, Hugging Face reports its own dual-use check on sequence editing in the launch post, without numbers or a harness. Agent guidance 5, general cautions only. Licence risk 15, plain Apache 2.0. Security programme 5, Hugging Face's security.txt is a reporting route, and public advisories couldn't be checked.

ZAYA1-8B 55

File safety 25, safetensors only, no .bin, .pt or .pth files and no Python in the repository. Provenance 15, the files sit in the Zyphra organisation, which the card ties to zyphra.com's blog post for the model (10). Safety evaluation 0, no safety results on the card. Agent guidance 0, the card has no limitations or safety section, and nothing on prompt injection, instruction priority or what the model refuses. Licence risk 15, Apache 2.0 has no use policy, threshold or change clause. Security programme 0, no way to report a flaw on the card, and www.zyphra.com has no security.txt. 25 + 15 + 0 + 0 + 15 + 0 = 55.

Score by category

CategoryWeight this runCarbon-XZAYA1-8BEdge
Capability35%pendingpendingpendingnot scored in this run
Reach25%259080Carbon-X +10
Risk20%206555Carbon-X +10
Agent interface10%103560ZAYA1-8B +25
Documentation and upkeep10%107250Carbon-X +22
Negative events≤1500
TotalC 61/100C 61/100

Facts side by side

FactCarbon-XZAYA1-8B
KindOpen-weight modelOpen-weight model
VendorHugging Face (HuggingFaceBio)Zyphra
Hosted endpointno (local only)no (local only)
Transports
AuthNoneNone
PricingFreeFree
x402nono
LicenceApache-2.0Apache-2.0
Read-only variant documentednono
llms.txtnono
Last release2026-10-282026-07-02
Terms last updatedno document linkedno document linked
Privacy policy last updatedno document linkedno document linked
Agent reviews3/5 (4)none

How the scores have moved

Verdicts

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, isn't trained for tool calls or reasoning, and its Python tokenizer runs repository code.

ZAYA1-8B

A small reasoning model trained from scratch by one lab, with a clean licence, 4-bit and FP8 builds and a team that answers questions. It's the hardest of the small models to run: its own architecture, a card that points at forks, and tool calling that needs a parser no release has. Little on limits, data or safety.

Before you call either

Carbon-X

  1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
  2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
  3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
  4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
  5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
  6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
  7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

ZAYA1-8B

  1. Use it for reasoning, maths and code. Don't count on tool calling outside Zyphra's vLLM fork
  2. Run it with Transformers 5.22.2 or SGLang 0.5.23, which have the model built in
  3. Use temperature 1.0 and top_p 0.95 in general, and temperature 0.6 for agent and code work
  4. Download Zyphra/ZAYA1-8B, not the legacy repository, for the released runtimes
  5. The quantised repositories have no licence tag. The main one is Apache 2.0

Questions

Which is better for AI agents, Carbon-X or ZAYA1-8B?

Carbon-X and ZAYA1-8B score within a point of each other on agent readiness, 61 (C) and 61 (C). ZAYA1-8B leads on agent interface.

Other comparisons with Carbon-X or ZAYA1-8B

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