Carbon-X vs LFM2.5-2.6B

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

LFM2.5-2.6B

A small, fast cousin for tool calls, extraction and long-context steps on a laptop or phone. Liquid's own 4-bit build is 1.6 GB, and every common runtime runs it. It always thinks, isn't meant for coding or knowledge-heavy work, and organisations over $10M of revenue need another licence. There are no safety results or security contact.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

LFM2.5-2.6B

1. Quickest start is ollama run LiquidAI/lfm2.5-2.6b, 1.7 GB, or llama-cli -hf LiquidAI/LFM2.5-2.6B-GGUF
2. With vLLM or SGLang pass --tool-call-parser lfm2; for vLLM add --reasoning-parser qwen3 so the thinking comes back separately
3. Sample at temperature 0.1, top_k 50 and repetition_penalty 1.1, as the card and generation_config.json set
4. Put tools in the system prompt as List of tools: [...] JSON, or pass tools to apply_chat_template; calls come back as a Python list of function calls, and the system prompt can ask for JSON calls instead
5. Leave max_tokens unset or generous, since a low cap cuts the reasoning off mid-thought
6. Earlier thinking is dropped from the prompt unless preserve_thinking is true
7. Liquid's 328M LFM2.5-2.6B-DSpark drafter speeds decoding about 2.6 times in SGLang and on Apple silicon, per Liquid
8. Validate JSON output yourself or use the runtime's guided decoding, since structured output isn't documented