Agents-A1-4B vs Carbon-X

Agents-A1-4B

A small agent cousin for search, research and tool-calling loops, with vision and 262,144 tokens of context. It runs in about 4 GB from InternScience's Q4_K_M GGUF, in vLLM, SGLang, Transformers or llama.cpp. The main risks are an undeclared base, no safety results or agent guidance, and a template that adds its own dated system prompt when you send none.

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Agents-A1-4B

1. Quickest start is llama-server -hf InternScience/Agents-A1-4B-Q4_K_M-GGUF --jinja, about 3.4 GB with the vision projector
2. With vLLM use --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, as on the card, and add --language-model-only for text-only work
3. Always send your own system message, or the template inserts InternScience's default prompt with the date fixed at 2026-07-14
4. The card recommends temperature 0.85, top_p 0.95, top_k 20, min_p 0 and presence_penalty 1.1, and there is no generation_config.json to set them
5. Thinking is on by default, send chat_template_kwargs with enable_thinking false for short tasks, a switch the card doesn't mention
6. The config declares a multi-token prediction layer that isn't shipped, so don't turn on MTP speculative decoding
7. Validate JSON output yourself, since structured output isn't documented

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades