# Agents-A1-4B vs Carbon-X

> Agents-A1-4B and Carbon-X score within a point of each other for open-weight models you run yourself, 61 and 61 out of 100. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x
- Markdown: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md (~5,950 tokens)
- Slim: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.min.md (~430 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

Agents-A1-4B and Carbon-X score within a point of each other on agent readiness, 61 (C) and 61 (C). Carbon-X leads on risk and documentation and upkeep. Both do open-weight models you run yourself.

- Agents-A1-4B: grade C, 61/100, rank #35 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/agents-a1-4b.md · JSON https://www.anchorterminal.com/api/v1/tools/agents-a1-4b.json
- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Agents-A1-4B (C)

Good for: Local agent loops (search, research, tool calls) on a laptop, a small GPU or a phone-class machine, under a plain licence

Ahead on:
- Agent interface, 70 against 35

Watch for: The base isn't declared, and the technical report doesn't cover the 4B

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Risk, 65 against 55
- Documentation and upkeep, 77 against 43

Watch for: Not clinically validated and no wet-lab validation reported


## Score by category

| Category | Weight | Agents-A1-4B | Carbon-X | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 90 | even |
| Risk | 20% (20 this run) | 55 | 65 | Carbon-X +10 |
| Agent interface | 10% (10 this run) | 70 | 35 | Agents-A1-4B +35 |
| Documentation and upkeep | 10% (10 this run) | 43 | 77 | Carbon-X +34 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **61 · C** | |

## Facts side by side

| Fact | Agents-A1-4B | Carbon-X |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | InternScience (Shanghai AI Laboratory) | Hugging Face (HuggingFaceBio) |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | Apache-2.0 |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-07-14 | 2026-10-22 |
| Terms last updated | no document linked | no document linked |
| Privacy policy last updated | no document linked | no document linked |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 3/5 (4) |

## Verdicts

**Agents-A1-4B.** A small agent cousin for search, research and tool-calling loops, with vision and 262,144 tokens of context. It runs in about 4 GB from InternScience's Q4_K_M GGUF, in vLLM, SGLang, Transformers or llama.cpp. The main risks are an undeclared base, no safety results or agent guidance, and a template that adds its own dated system prompt when you send none.

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

## Before you call either

### Agents-A1-4B

1. Quickest start is `llama-server -hf InternScience/Agents-A1-4B-Q4_K_M-GGUF --jinja`, about 3.4 GB with the vision projector
2. With vLLM use `--reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder`, as on the card, and add `--language-model-only` for text-only work
3. Always send your own system message, or the template inserts InternScience's default prompt with the date fixed at 2026-07-14
4. The card recommends temperature 0.85, top_p 0.95, top_k 20, min_p 0 and presence_penalty 1.1, and there is no generation_config.json to set them
5. Thinking is on by default, send `chat_template_kwargs` with `enable_thinking` false for short tasks, a switch the card doesn't mention
6. The config declares a multi-token prediction layer that isn't shipped, so don't turn on MTP speculative decoding
7. Validate JSON output yourself, since structured output isn't documented

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

## Questions

### Which is better for AI agents, Agents-A1-4B or Carbon-X?

Agents-A1-4B and Carbon-X score within a point of each other on agent readiness, 61 (C) and 61 (C). Carbon-X leads on risk and documentation and upkeep.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.json, and with the fewest tokens: https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "agents-a1-4b", "b": "carbon-x"}`. From a terminal: `anchor compare agents-a1-4b carbon-x`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/agents-a1-4b.json and https://www.anchorterminal.com/api/v1/tools/carbon-x.json

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- [Carbon-X vs Ling-3.0-tiny](https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny.md)
- [Carbon-X vs MiMo-V2.6 Distill Qwen 9B](https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b.md)
- [Carbon-X vs MiniCPM-o 4.5](https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5.md)
- [Carbon-X vs MiniCPM5-2B](https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b.md)
- [Carbon-X vs MiniMax-M2.5](https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5.md)
- [Carbon-X vs MiniMax-M2.7](https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7.md)
- [Carbon-X vs Muse Glimmer 30B](https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b.md)
- [Carbon-X vs Nemotron 3.5 Lightning 30B A3B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-lightning-30b-a3b.md)
- [Carbon-X vs Nemotron 3 Nano 30B A3B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-30b-a3b.md)
- [Carbon-X vs Nemotron 3 Nano 4B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-4b.md)
- [Carbon-X vs Nemotron 3 Nano Omni 30B A3B Reasoning](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-omni-30b-a3b-reasoning.md)
- [Carbon-X vs Nemotron 3 Super 120B A12B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b.md)
- [Carbon-X vs Nemotron 3 Ultra 550B A55B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-ultra-550b-a55b.md)
- [Carbon-X vs occamy-1.0](https://www.anchorterminal.com/compare/carbon-x-vs-occamy-1-0.md)
- [Carbon-X vs Olmo 3 7B Think](https://www.anchorterminal.com/compare/carbon-x-vs-olmo-3-7b-think.md)
- [Carbon-X vs Ornith-1.5-35B-A3B](https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-35b-a3b.md)
- [Carbon-X vs Ornith-1.5-397B](https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.md)
- [Carbon-X vs Ornith-1.5-9B](https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-9b.md)
- [Carbon-X vs Qwen3-30B-A3B-Instruct-2507](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-30b-a3b-instruct-2507.md)
- [Carbon-X vs Qwen3-4B-Instruct-2507](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-4b-instruct-2507.md)
- [Carbon-X vs Qwen3.5-0.8B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-0-8b.md)
- [Carbon-X vs Qwen3.5-122B-A10B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-122b-a10b.md)
- [Carbon-X vs Qwen3.5-2B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-2b.md)
- [Carbon-X vs Qwen3.5-397B-A17B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-397b-a17b.md)
- [Carbon-X vs Qwen3.5-4B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-4b.md)
- [Carbon-X vs Qwen3.5-9B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-5-9b.md)
- [Carbon-X vs Qwen3.6-27B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-6-27b.md)
- [Carbon-X vs Qwen3.6-35B-A3B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-6-35b-a3b.md)
- [Carbon-X vs Qwen3.8-27B](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-8-27b.md)
- [Carbon-X vs Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-8-flash-next.md)
- [Carbon-X vs Qwen3-Coder-30B-A3B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-30b-a3b-instruct.md)
- [Carbon-X vs Qwen3-Coder-Next](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-next.md)
- [Carbon-X vs Qwen3-Omni-30B-A3B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-omni-30b-a3b-instruct.md)
- [Carbon-X vs Qwen3-VL-2B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-2b-instruct.md)
- [Carbon-X vs Qwen3-VL-30B-A3B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-30b-a3b-instruct.md)
- [Carbon-X vs Qwen3-VL-32B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-32b-instruct.md)
- [Carbon-X vs Qwen3-VL-4B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-4b-instruct.md)
- [Carbon-X vs Qwen3-VL-8B-Instruct](https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-8b-instruct.md)
- [Carbon-X vs Qwopus3.8-27B-Flash-V2](https://www.anchorterminal.com/compare/carbon-x-vs-qwopus3-8-27b-flash-v2.md)
- [Carbon-X vs Recursive Flint](https://www.anchorterminal.com/compare/carbon-x-vs-recursive-flint.md)
- [Carbon-X vs SmolLM3-3B](https://www.anchorterminal.com/compare/carbon-x-vs-smollm3-3b.md)
- [Carbon-X vs Spark-X2.6-4B](https://www.anchorterminal.com/compare/carbon-x-vs-spark-x2-6-4b.md)
- [Carbon-X vs Swift 1.5 Qwen3.8-27B](https://www.anchorterminal.com/compare/carbon-x-vs-swift-1-5-qwen3-8-27b.md)
- [Carbon-X vs Swift 1.5 Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/carbon-x-vs-swift-1-5-qwen3-8-flash-next.md)
- [Carbon-X vs ThinkingCap (Qwen3.8 27B)](https://www.anchorterminal.com/compare/carbon-x-vs-thinkingcap-qwen3-8-27b.md)

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