Carbon-X vs Ornith-1.5-397B

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Ornith-1.5-397B

Ornith's flagship coding and terminal-agent cousin, with XML tool calls that vLLM and SGLang parse and 262,144 tokens of context. It needs about 290 GB even at 4 bits, so a multi-GPU server, not the 128 GB reference machine. The main risk is an absent publisher, with no licence file, no safety results and files replaced without a note.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Ornith-1.5-397B

1. Start it with the card's vLLM command at --tensor-parallel-size 8, or ollama run ornith-1.5:397b on a machine with about 300 GB of memory
2. In vLLM pass --enable-auto-tool-choice --tool-call-parser qwen3_xml --reasoning-parser qwen3, and in SGLang --tool-call-parser qwen3_coder --reasoning-parser qwen3, so tool calls and reasoning come back parsed
3. Thinking is on by default. Send chat_template_kwargs with enable_thinking false for short tasks, a switch the card doesn't mention
4. Pin which template your runtime loads, since chat_template.jinja keeps earlier reasoning and the tokenizer_config.json template drops it
5. When downloading the NVFP4 build, fetch only the files its model.safetensors.index.json names (the 25-shard set, 241.7 GB), not the eight extra shards
6. Pin a revision when you download, since Ornith has replaced files in place
7. Validate JSON output yourself, since structured output isn't documented