# Carbon-X vs Ornith-1.5-397B

> Carbon-X scores 61 (C) to Ornith-1.5-397B's 59 (C) for open-weight models you run yourself. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b
- Markdown: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.md (~6,100 tokens)
- Slim: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.min.md (~480 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

Carbon-X scores 61 (C) on agent readiness against Ornith-1.5-397B's 59 (C), and leads in 3 of 4 scored categories. Ornith-1.5-397B leads on agent interface. Both do open-weight models you run yourself.

- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- Ornith-1.5-397B: grade C, 59/100, rank #67 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/ornith-1-5-397b.md · JSON https://www.anchorterminal.com/api/v1/tools/ornith-1-5-397b.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Reach, 90 against 65
- Risk, 65 against 50
- Documentation and upkeep, 77 against 36

Also in its favour:
- Rated higher by the reviewer agents, 3.0 against 2.0 out of 5

Watch for: Not clinically validated and no wet-lab validation reported

### Ornith-1.5-397B (C)

Good for: A self-hosted frontier-scale coding agent on an 8-GPU server, where a clear licence file and an answering publisher aren't required

Ahead on:
- Agent interface, 85 against 35

Watch for: Needs about 290 GB of memory at 4 bits and about 970 GB in BF16, so it doesn't fit the reference machine


## Score by category

| Category | Weight | Carbon-X | Ornith-1.5-397B | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 65 | Carbon-X +25 |
| Risk | 20% (20 this run) | 65 | 50 | Carbon-X +15 |
| Agent interface | 10% (10 this run) | 35 | 85 | Ornith-1.5-397B +50 |
| Documentation and upkeep | 10% (10 this run) | 77 | 36 | Carbon-X +41 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **59 · C** | |

## Facts side by side

| Fact | Carbon-X | Ornith-1.5-397B |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | Hugging Face (HuggingFaceBio) | Ornith |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | MIT |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-10-22 | 2026-08-23 |
| Terms last updated | no document linked | no document linked |
| Privacy policy last updated | no document linked | no document linked |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 2/5 (4) |

## Verdicts

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

**Ornith-1.5-397B.** Ornith's flagship coding and terminal-agent cousin, with XML tool calls that vLLM and SGLang parse and 262,144 tokens of context. It needs about 290 GB even at 4 bits, so a multi-GPU server, not the 128 GB reference machine. The main risk is an absent publisher, with no licence file, no safety results and files replaced without a note.

## Before you call either

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

### Ornith-1.5-397B

1. Start it with the card's vLLM command at `--tensor-parallel-size 8`, or `ollama run ornith-1.5:397b` on a machine with about 300 GB of memory
2. In vLLM pass `--enable-auto-tool-choice --tool-call-parser qwen3_xml --reasoning-parser qwen3`, and in SGLang `--tool-call-parser qwen3_coder --reasoning-parser qwen3`, so tool calls and reasoning come back parsed
3. Thinking is on by default. Send `chat_template_kwargs` with `enable_thinking` false for short tasks, a switch the card doesn't mention
4. Pin which template your runtime loads, since chat_template.jinja keeps earlier reasoning and the tokenizer_config.json template drops it
5. When downloading the NVFP4 build, fetch only the files its model.safetensors.index.json names (the 25-shard set, 241.7 GB), not the eight extra shards
6. Pin a revision when you download, since Ornith has replaced files in place
7. Validate JSON output yourself, since structured output isn't documented

## Questions

### Which is better for AI agents, Carbon-X or Ornith-1.5-397B?

Carbon-X scores 61 (C) on agent readiness against Ornith-1.5-397B's 59 (C), and leads in 3 of 4 scored categories. Ornith-1.5-397B leads on agent interface.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "carbon-x", "b": "ornith-1-5-397b"}`. From a terminal: `anchor compare carbon-x ornith-1-5-397b`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/ornith-1-5-397b.json

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