Carbon-X vs Darwin-36B-Opus

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Darwin-36B-Opus

A text-only reasoning cousin merged from Qwen3.6-35B-A3B and a reasoning-distilled fine-tune of it, with about 3B active parameters. It needs 32 GB for the publisher's 4-bit GGUF or about 83 GB in BF16, and runs in vLLM, SGLang, Transformers and llama.cpp. The main risks are an undisclosed merge method, a card that disagrees with its files, and no safety results.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Darwin-36B-Opus

1. Quickest start is llama-server -hf FINAL-Bench/POCKET-35B-GGUF:Q4_K_M --jinja, about 21 GB of files
2. On the reference machine BF16 fits, vllm serve FINAL-Bench/Darwin-36B-Opus --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, the parsers for Qwen3.6's format
3. Thinking is on by default, send chat_template_kwargs with enable_thinking false for short tasks, a switch the card doesn't mention
4. The card suggests temperature 0.6 to 0.7 and at least 5,120 new tokens for its think traces
5. generation_config.json stops only on the end-of-text token, so add <|im_end|> as a stop token if a runtime keeps generating after the turn ends
6. Text only, the vision encoder of Qwen3.6-35B-A3B isn't in these files
7. Validate JSON output yourself, since structured output isn't documented