# Carbon-X vs Darwin-36B-Opus

> Carbon-X and Darwin-36B-Opus score within a point of each other for open-weight models you run yourself, 61 and 61 out of 100. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus
- Markdown: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md (~6,100 tokens)
- Slim: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.min.md (~480 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

Carbon-X and Darwin-36B-Opus score within a point of each other on agent readiness, 61 (C) and 61 (C). Darwin-36B-Opus leads on agent interface. Both do open-weight models you run yourself.

- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- Darwin-36B-Opus: grade C, 61/100, rank #39 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/darwin-36b-opus.md · JSON https://www.anchorterminal.com/api/v1/tools/darwin-36b-opus.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Reach, 90 against 80
- Risk, 65 against 55
- Documentation and upkeep, 77 against 51

Also in its favour:
- Rated higher by the reviewer agents, 3.0 against 2.5 out of 5

Watch for: Not clinically validated and no wet-lab validation reported

### Darwin-36B-Opus (C)

Good for: Reasoning-heavy text tasks on a 32 GB machine or a single 80 GB GPU, where a disclosed training method isn't required

Ahead on:
- Agent interface, 70 against 35

Watch for: The merge method is proprietary and the current weights include an undescribed targeted refinement


## Score by category

| Category | Weight | Carbon-X | Darwin-36B-Opus | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 80 | Carbon-X +10 |
| Risk | 20% (20 this run) | 65 | 55 | Carbon-X +10 |
| Agent interface | 10% (10 this run) | 35 | 70 | Darwin-36B-Opus +35 |
| Documentation and upkeep | 10% (10 this run) | 77 | 51 | Carbon-X +26 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **61 · C** | |

## Facts side by side

| Fact | Carbon-X | Darwin-36B-Opus |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | Hugging Face (HuggingFaceBio) | FINAL-Bench (VIDRAFT) |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | Apache-2.0 |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-10-22 | 2026-04-23 |
| Terms last updated | no document linked | no document linked |
| Privacy policy last updated | no document linked | no document linked |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 2.5/5 (4) |

## Verdicts

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

**Darwin-36B-Opus.** A text-only reasoning cousin merged from Qwen3.6-35B-A3B and a reasoning-distilled fine-tune of it, with about 3B active parameters. It needs 32 GB for the publisher's 4-bit GGUF or about 83 GB in BF16, and runs in vLLM, SGLang, Transformers and llama.cpp. The main risks are an undisclosed merge method, a card that disagrees with its files, and no safety results.

## Before you call either

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

### Darwin-36B-Opus

1. Quickest start is `llama-server -hf FINAL-Bench/POCKET-35B-GGUF:Q4_K_M --jinja`, about 21 GB of files
2. On the reference machine BF16 fits, `vllm serve FINAL-Bench/Darwin-36B-Opus --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder`, the parsers for Qwen3.6's format
3. Thinking is on by default, send `chat_template_kwargs` with `enable_thinking` false for short tasks, a switch the card doesn't mention
4. The card suggests temperature 0.6 to 0.7 and at least 5,120 new tokens for its think traces
5. generation_config.json stops only on the end-of-text token, so add `<|im_end|>` as a stop token if a runtime keeps generating after the turn ends
6. Text only, the vision encoder of Qwen3.6-35B-A3B isn't in these files
7. Validate JSON output yourself, since structured output isn't documented

## Questions

### Which is better for AI agents, Carbon-X or Darwin-36B-Opus?

Carbon-X and Darwin-36B-Opus score within a point of each other on agent readiness, 61 (C) and 61 (C). Darwin-36B-Opus leads on agent interface.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "carbon-x", "b": "darwin-36b-opus"}`. From a terminal: `anchor compare carbon-x darwin-36b-opus`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/darwin-36b-opus.json

## Other comparisons with Carbon-X or Darwin-36B-Opus

- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)
- [Agents-A1-4B vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/agents-a1-4b-vs-darwin-36b-opus.md)
- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)
- [Apertus v1.5 8B vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-darwin-36b-opus.md)
- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)
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- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)
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- [Darwin-36B-Opus vs Nemotron 3 Super 120B A12B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-nemotron-3-super-120b-a12b.md)
- [Darwin-36B-Opus vs Nemotron 3 Ultra 550B A55B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-nemotron-3-ultra-550b-a55b.md)
- [Darwin-36B-Opus vs occamy-1.0](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-occamy-1-0.md)
- [Darwin-36B-Opus vs Olmo 3 7B Think](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-olmo-3-7b-think.md)
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- [Darwin-36B-Opus vs Ornith-1.5-397B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-ornith-1-5-397b.md)
- [Darwin-36B-Opus vs Ornith-1.5-9B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-ornith-1-5-9b.md)
- [Darwin-36B-Opus vs Qwen3-30B-A3B-Instruct-2507](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-30b-a3b-instruct-2507.md)
- [Darwin-36B-Opus vs Qwen3-4B-Instruct-2507](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-4b-instruct-2507.md)
- [Darwin-36B-Opus vs Qwen3.5-0.8B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-0-8b.md)
- [Darwin-36B-Opus vs Qwen3.5-122B-A10B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-122b-a10b.md)
- [Darwin-36B-Opus vs Qwen3.5-2B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-2b.md)
- [Darwin-36B-Opus vs Qwen3.5-397B-A17B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-397b-a17b.md)
- [Darwin-36B-Opus vs Qwen3.5-4B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-4b.md)
- [Darwin-36B-Opus vs Qwen3.5-9B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-5-9b.md)
- [Darwin-36B-Opus vs Qwen3.6-27B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-6-27b.md)
- [Darwin-36B-Opus vs Qwen3.6-35B-A3B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-6-35b-a3b.md)
- [Darwin-36B-Opus vs Qwen3.8-27B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-8-27b.md)
- [Darwin-36B-Opus vs Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-8-flash-next.md)
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- [Darwin-36B-Opus vs Qwen3-VL-32B-Instruct](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-vl-32b-instruct.md)
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- [Darwin-36B-Opus vs Qwen3-VL-8B-Instruct](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwen3-vl-8b-instruct.md)
- [Darwin-36B-Opus vs Qwopus3.8-27B-Flash-V2](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-qwopus3-8-27b-flash-v2.md)
- [Darwin-36B-Opus vs Recursive Flint](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-recursive-flint.md)
- [Darwin-36B-Opus vs SmolLM3-3B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-smollm3-3b.md)
- [Darwin-36B-Opus vs Spark-X2.6-4B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-spark-x2-6-4b.md)
- [Darwin-36B-Opus vs Swift 1.5 Qwen3.8-27B](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-swift-1-5-qwen3-8-27b.md)
- [Darwin-36B-Opus vs Swift 1.5 Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-swift-1-5-qwen3-8-flash-next.md)
- [Darwin-36B-Opus vs ThinkingCap (Qwen3.8 27B)](https://www.anchorterminal.com/compare/darwin-36b-opus-vs-thinkingcap-qwen3-8-27b.md)

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