Carbon-X vs Kolibri-1

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

Kolibri-1

Kolibri-1 is a German and English reasoning model with a documented tool-call format, switchable thinking and a 262,144-token context, under Apache 2.0. Aleph Alpha's FP8 build needs about 95 GB and runs on vLLM through its plugin, Transformers 5.20 or recent llama.cpp. The main risk is no published safety results or security contact, and few repository answers.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

Kolibri-1

1. Start it with pip install 'aleph-alpha-inference>=1' then vllm serve Aleph-Alpha/Kolibri-1 --kv-cache-dtype fp8 --reasoning-parser kolibri1 --tool-call-parser kolibri1 --enable-auto-tool-choice
2. Without the kolibri1 tool-call parser and enable-auto-tool-choice, tool calls come back as text in tool_call tags
3. The plugin supports one vLLM minor version, 0.29, so don't upgrade vLLM while it's installed
4. Thinking is on by default at high effort. Pass reasoning_effort none or enable_thinking false in chat_template_kwargs for short tasks
5. Recommended sampling is temperature 1.0, top_p 0.97 and top_k 128
6. Past 262,144 tokens, add --max-model-len 1048576 and the max_position_embeddings override in --hf-overrides, though Aleph Alpha recommends staying at or below 262,144
7. With Transformers 5.20 or later, tokenizer.parse_response returns the answer in content and the reasoning in thinking
8. On the reference machine the FP8 build fits by size, but no document confirms vLLM runs FP8 on gfx1151, and Aleph Alpha ships no GGUF for llama.cpp
9. Validate tool results in your own code, as the card asks