Carbon-X vs SmolLM3-3B

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

SmolLM3-3B

A tiny, fully open cousin with documented tool calling and switchable thinking, for local subtasks and routing on laptops and CPUs. It needs about 8 GB in BF16, or under 3 GB in Hugging Face's 4-bit ONNX build for ONNX Runtime. The main risks are a 64K native context, no safety results and no repository changes since September 2025.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

SmolLM3-3B

1. Start it with vllm serve HuggingFaceTB/SmolLM3-3B --enable-auto-tool-choice --tool-call-parser=hermes, or tool calls come back as text
2. Pass chat_template_kwargs with enable_thinking false for short tasks, since thinking is on by default; a /think or /no_think flag in the system prompt overrides the kwarg
3. Put earlier tool calls in the assistant message content, since the template ignores a tool_calls field when it renders history
4. Add the YaRN rope_scaling block (factor 2.0, original 65536) to config.json before sending more than 65,536 tokens
5. Use temperature 0.6 and top_p 0.95, the card's recommended sampling
6. Needs Transformers v4.53.0 or later; for llama.cpp use a GGUF from ggml-org or another converter, since Hugging Face publishes none
7. Validate JSON output yourself or use the runtime's guided decoding