Carbon-X vs gpt-oss-120b

Carbon-X

A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

gpt-oss-120b

A reasoning and agent cousin that runs in most runtimes under Apache 2.0 with published safety work. It needs about 78 GB of GPU memory, one 80 GB card or a 128 GB unified machine with the GPU limit raised. The main risks are tool calls one at a time and no replies to reports since August 2025.

Carbon-X

1. Quickest start is llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

gpt-oss-120b

1. Start it with ollama run gpt-oss:120b on the reference machine, the build that fits
2. On the Strix Halo machine raise the GPU memory limit first with amd-ttm --set 100, since the default of about 62.8 GiB is below the 78 GB it needs
3. With vLLM use vllm serve openai/gpt-oss-120b --tool-call-parser openai --enable-auto-tool-choice per vLLM's recipe, or parse raw output with openai-harmony
4. Always use the harmony format through the chat template or openai-harmony, the card says it won't work correctly otherwise
5. Set Reasoning: low in the system message for short tasks, medium is the default
6. Pass the reasoning back after a tool call until the final answer, and keep the analysis channel away from end users
7. Expect one tool call per turn and loop, don't wait for parallel calls