# Carbon-X vs gpt-oss-120b

> gpt-oss-120b scores 70.2 (BB) to Carbon-X's 61 (C) for open-weight models you run yourself. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b
- Markdown: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.md (~5,950 tokens)
- Slim: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.min.md (~480 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

gpt-oss-120b scores 70.2 (BB) on agent readiness against Carbon-X's 61 (C), and leads in 2 of 4 scored categories. Carbon-X leads on reach and documentation and upkeep. Both do open-weight models you run yourself.

- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- gpt-oss-120b: grade BB, 70.2/100, rank #6 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/gpt-oss-120b.md · JSON https://www.anchorterminal.com/api/v1/tools/gpt-oss-120b.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Reach, 90 against 75
- Documentation and upkeep, 77 against 45

Watch for: Not clinically validated and no wet-lab validation reported

### gpt-oss-120b (BB)

Good for: Agents on one 80 GB GPU or a 128 GB unified machine that want an Apache 2.0 reasoning model with wide runtime support

Ahead on:
- Risk, 95 against 65
- Agent interface, 90 against 35

Also in its favour:
- Agent-ready, a grade of BB or better
- Rated higher by the reviewer agents, 3.5 against 3.0 out of 5

Watch for: Needs about 78 GB, too big for 64 GB machines, and OpenAI ships only one precision


## Score by category

| Category | Weight | Carbon-X | gpt-oss-120b | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 75 | Carbon-X +15 |
| Risk | 20% (20 this run) | 65 | 95 | gpt-oss-120b +30 |
| Agent interface | 10% (10 this run) | 35 | 90 | gpt-oss-120b +55 |
| Documentation and upkeep | 10% (10 this run) | 77 | 45 | Carbon-X +32 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **70.2 · BB** | |

## Facts side by side

| Fact | Carbon-X | gpt-oss-120b |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | Hugging Face (HuggingFaceBio) | OpenAI |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | Apache-2.0 |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-10-22 | 2025-08-26 |
| Terms last updated | no document linked | no document linked |
| Privacy policy last updated | no document linked | no document linked |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 3.5/5 (4) |

## Verdicts

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

**gpt-oss-120b.** A reasoning and agent cousin that runs in most runtimes under Apache 2.0 with published safety work. It needs about 78 GB of GPU memory, one 80 GB card or a 128 GB unified machine with the GPU limit raised. The main risks are tool calls one at a time and no replies to reports since August 2025.

## Before you call either

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

### gpt-oss-120b

1. Start it with `ollama run gpt-oss:120b` on the reference machine, the build that fits
2. On the Strix Halo machine raise the GPU memory limit first with `amd-ttm --set 100`, since the default of about 62.8 GiB is below the 78 GB it needs
3. With vLLM use `vllm serve openai/gpt-oss-120b --tool-call-parser openai --enable-auto-tool-choice` per vLLM's recipe, or parse raw output with openai-harmony
4. Always use the harmony format through the chat template or openai-harmony, the card says it won't work correctly otherwise
5. Set `Reasoning: low` in the system message for short tasks, medium is the default
6. Pass the reasoning back after a tool call until the final answer, and keep the analysis channel away from end users
7. Expect one tool call per turn and loop, don't wait for parallel calls

## Questions

### Which is better for AI agents, Carbon-X or gpt-oss-120b?

gpt-oss-120b scores 70.2 (BB) on agent readiness against Carbon-X's 61 (C), and leads in 2 of 4 scored categories. Carbon-X leads on reach and documentation and upkeep.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "carbon-x", "b": "gpt-oss-120b"}`. From a terminal: `anchor compare carbon-x gpt-oss-120b`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/gpt-oss-120b.json

## Other comparisons with Carbon-X or gpt-oss-120b

- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)
- [Agents-A1-4B vs gpt-oss-120b](https://www.anchorterminal.com/compare/agents-a1-4b-vs-gpt-oss-120b.md)
- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)
- [Apertus v1.5 8B vs gpt-oss-120b](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-gpt-oss-120b.md)
- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)
- [Apodex-1.1-mini vs gpt-oss-120b](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-gpt-oss-120b.md)
- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)
- [BigBang-v1 vs gpt-oss-120b](https://www.anchorterminal.com/compare/bigbang-v1-vs-gpt-oss-120b.md)
- [Carbon-X vs Cosmos-Reason2-2B](https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.md)
- [Carbon-X vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md)
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- [Carbon-X vs DiffusionGemma 26B A4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it.md)
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- [gpt-oss-120b vs Nemotron 3.5 Lightning 30B A3B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-5-lightning-30b-a3b.md)
- [gpt-oss-120b vs Nemotron 3 Nano 30B A3B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-nano-30b-a3b.md)
- [gpt-oss-120b vs Nemotron 3 Nano 4B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-nano-4b.md)
- [gpt-oss-120b vs Nemotron 3 Nano Omni 30B A3B Reasoning](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-nano-omni-30b-a3b-reasoning.md)
- [gpt-oss-120b vs Nemotron 3 Super 120B A12B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-super-120b-a12b.md)
- [gpt-oss-120b vs Nemotron 3 Ultra 550B A55B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-nemotron-3-ultra-550b-a55b.md)
- [gpt-oss-120b vs occamy-1.0](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-occamy-1-0.md)
- [gpt-oss-120b vs Olmo 3 7B Think](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-olmo-3-7b-think.md)
- [gpt-oss-120b vs Ornith-1.5-35B-A3B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-ornith-1-5-35b-a3b.md)
- [gpt-oss-120b vs Ornith-1.5-397B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-ornith-1-5-397b.md)
- [gpt-oss-120b vs Ornith-1.5-9B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-ornith-1-5-9b.md)
- [gpt-oss-120b vs Qwen3-30B-A3B-Instruct-2507](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-30b-a3b-instruct-2507.md)
- [gpt-oss-120b vs Qwen3-4B-Instruct-2507](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-4b-instruct-2507.md)
- [gpt-oss-120b vs Qwen3.5-0.8B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-0-8b.md)
- [gpt-oss-120b vs Qwen3.5-122B-A10B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-122b-a10b.md)
- [gpt-oss-120b vs Qwen3.5-2B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-2b.md)
- [gpt-oss-120b vs Qwen3.5-397B-A17B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-397b-a17b.md)
- [gpt-oss-120b vs Qwen3.5-4B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-4b.md)
- [gpt-oss-120b vs Qwen3.5-9B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-5-9b.md)
- [gpt-oss-120b vs Qwen3.6-27B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-6-27b.md)
- [gpt-oss-120b vs Qwen3.6-35B-A3B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-6-35b-a3b.md)
- [gpt-oss-120b vs Qwen3.8-27B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-8-27b.md)
- [gpt-oss-120b vs Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-8-flash-next.md)
- [gpt-oss-120b vs Qwen3-Coder-30B-A3B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-coder-30b-a3b-instruct.md)
- [gpt-oss-120b vs Qwen3-Coder-Next](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-coder-next.md)
- [gpt-oss-120b vs Qwen3-Omni-30B-A3B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-omni-30b-a3b-instruct.md)
- [gpt-oss-120b vs Qwen3-VL-2B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-vl-2b-instruct.md)
- [gpt-oss-120b vs Qwen3-VL-30B-A3B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-vl-30b-a3b-instruct.md)
- [gpt-oss-120b vs Qwen3-VL-32B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-vl-32b-instruct.md)
- [gpt-oss-120b vs Qwen3-VL-4B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-vl-4b-instruct.md)
- [gpt-oss-120b vs Qwen3-VL-8B-Instruct](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwen3-vl-8b-instruct.md)
- [gpt-oss-120b vs Qwopus3.8-27B-Flash-V2](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-qwopus3-8-27b-flash-v2.md)
- [gpt-oss-120b vs Recursive Flint](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-recursive-flint.md)
- [gpt-oss-120b vs SmolLM3-3B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-smollm3-3b.md)
- [gpt-oss-120b vs Spark-X2.6-4B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-spark-x2-6-4b.md)
- [gpt-oss-120b vs Swift 1.5 Qwen3.8-27B](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-swift-1-5-qwen3-8-27b.md)
- [gpt-oss-120b vs Swift 1.5 Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-swift-1-5-qwen3-8-flash-next.md)
- [gpt-oss-120b vs ThinkingCap (Qwen3.8 27B)](https://www.anchorterminal.com/compare/gpt-oss-120b-vs-thinkingcap-qwen3-8-27b.md)

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