gpt-oss-120b vs Qwen3.5-122B-A10B

gpt-oss-120b

A reasoning and agent cousin that runs in most runtimes under Apache 2.0 with published safety work. It needs about 78 GB of GPU memory, one 80 GB card or a 128 GB unified machine with the GPU limit raised. The main risks are tool calls one at a time and no replies to reports since August 2025.

Qwen3.5-122B-A10B

A strong mid-size cousin for coding, agent steps and reading images or video, with thinking you can switch off per request. Alibaba's 4-bit build needs about 95 GB, which fits one 128 GB unified-memory machine, and several providers host it. The main risk is silence, with no safety results, agent guidance or answers from Alibaba.

gpt-oss-120b

1. Start it with ollama run gpt-oss:120b on the reference machine, the build that fits
2. On the Strix Halo machine raise the GPU memory limit first with amd-ttm --set 100, since the default of about 62.8 GiB is below the 78 GB it needs
3. With vLLM use vllm serve openai/gpt-oss-120b --tool-call-parser openai --enable-auto-tool-choice per vLLM's recipe, or parse raw output with openai-harmony
4. Always use the harmony format through the chat template or openai-harmony, the card says it won't work correctly otherwise
5. Set Reasoning: low in the system message for short tasks, medium is the default
6. Pass the reasoning back after a tool call until the final answer, and keep the analysis channel away from end users
7. Expect one tool call per turn and loop, don't wait for parallel calls

Qwen3.5-122B-A10B

1. Quickest start on a 128 GB machine is ollama run qwen3.5:122b (Q4_K_M, 81 GB of files, about 97 GB with context)
2. Alibaba's 4-bit build serves with vllm serve Qwen/Qwen3.5-122B-A10B-GPTQ-Int4 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --quantization moe_wna16, though that kernel isn't documented for AMD gfx1151
3. Use the qwen3_coder tool parser and the qwen3 reasoning parser, as the card's commands do
4. Turn thinking off with "chat_template_kwargs": {"enable_thinking": false} in the request body, since it's on by default and /think and /nothink aren't supported
5. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Add --language-model-only in vLLM to skip the vision encoder and free memory for the KV cache when you only need text
8. Validate any JSON it returns, since structured output isn't documented