MiniCPM-o 4.5 vs Qwen3.5-122B-A10B

MiniCPM-o 4.5

A small omni cousin that sees, listens and talks back, with full-duplex speech and voice cloning, in about 7 GB at 4-bit through llama.cpp or Ollama for text and images. Speech output needs OpenBMB's remote code or llama.cpp-omni, and 28 GB of GPU for the full demo. The main risks are repository code and pickle files and no safety results.

Qwen3.5-122B-A10B

A strong mid-size cousin for coding, agent steps and reading images or video, with thinking you can switch off per request. Alibaba's 4-bit build needs about 95 GB, which fits one 128 GB unified-memory machine, and several providers host it. The main risk is silence, with no safety results, agent guidance or answers from Alibaba.

MiniCPM-o 4.5

1. Quickest start for text and images is ollama run openbmb/minicpm-o4.5, about 6 GB
2. With vLLM 0.16.0 or later pass --trust-remote-code, and send stop_token_ids [151643, 151645] as OpenBMB's guide does
3. vLLM, llama.cpp and Ollama return text only; for speech out use the card's Transformers 4.51.0 code or OpenBMB's llama.cpp-omni
4. In llama.cpp pass both the language GGUF and MiniCPM-o-4_5-vision-F16.gguf with --mmproj, and use --jinja --reasoning-budget 0 to turn thinking off
5. Keep prompts within 40,960 tokens
6. Don't rely on tool calls or JSON output, neither is documented; validate any you get

Qwen3.5-122B-A10B

1. Quickest start on a 128 GB machine is ollama run qwen3.5:122b (Q4_K_M, 81 GB of files, about 97 GB with context)
2. Alibaba's 4-bit build serves with vllm serve Qwen/Qwen3.5-122B-A10B-GPTQ-Int4 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --quantization moe_wna16, though that kernel isn't documented for AMD gfx1151
3. Use the qwen3_coder tool parser and the qwen3 reasoning parser, as the card's commands do
4. Turn thinking off with "chat_template_kwargs": {"enable_thinking": false} in the request body, since it's on by default and /think and /nothink aren't supported
5. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Add --language-model-only in vLLM to skip the vision encoder and free memory for the KV cache when you only need text
8. Validate any JSON it returns, since structured output isn't documented