MiniCPM-o 4.5 vs Qwen3.5-2B

MiniCPM-o 4.5

A small omni cousin that sees, listens and talks back, with full-duplex speech and voice cloning, in about 7 GB at 4-bit through llama.cpp or Ollama for text and images. Speech output needs OpenBMB's remote code or llama.cpp-omni, and 28 GB of GPU for the full demo. The main risks are repository code and pickle files and no safety results.

Qwen3.5-2B

A small vision-language cousin for prototypes, fine-tuning and light local steps such as tool calls, tagging or reading an image, running in about 2 GB at 4 bits in every major runtime under plain Apache 2.0. Keep thinking off, since the card warns it loops. The main risk is neglect, with no safety results or answers from Alibaba since March.

MiniCPM-o 4.5

1. Quickest start for text and images is ollama run openbmb/minicpm-o4.5, about 6 GB
2. With vLLM 0.16.0 or later pass --trust-remote-code, and send stop_token_ids [151643, 151645] as OpenBMB's guide does
3. vLLM, llama.cpp and Ollama return text only; for speech out use the card's Transformers 4.51.0 code or OpenBMB's llama.cpp-omni
4. In llama.cpp pass both the language GGUF and MiniCPM-o-4_5-vision-F16.gguf with --mmproj, and use --jinja --reasoning-budget 0 to turn thinking off
5. Keep prompts within 40,960 tokens
6. Don't rely on tool calls or JSON output, neither is documented; validate any you get

Qwen3.5-2B

1. Smallest start is ollama run qwen3.5:2b-q4_K_M (1.9 GB); plain qwen3.5:2b pulls the 2.7 GB Q8_0 build
2. Full precision vllm serve Qwen/Qwen3.5-2B --port 8000 --max-model-len 262144 --enable-auto-tool-choice --tool-call-parser qwen3_coder
3. Thinking is off by default; if you turn it on with "chat_template_kwargs": {"enable_thinking": true}, stream and cut off runaway output, since the card warns of thinking loops, and add --reasoning-parser qwen3 in vLLM or SGLang to split the reasoning out
4. There's no generation_config.json, so pass the card's sampling yourself, for example temperature=1.0, top_p=1.0, top_k=20, presence_penalty=2.0 for text without thinking
5. Use it for narrow steps or as a fine-tuning base, not as the main agent, as the card itself suggests
6. Validate any JSON it returns, since structured output isn't documented