MiniCPM-o 4.5 vs Nemotron 3 Nano Omni 30B A3B Reasoning

MiniCPM-o 4.5

A small omni cousin that sees, listens and talks back, with full-duplex speech and voice cloning, in about 7 GB at 4-bit through llama.cpp or Ollama for text and images. Speech output needs OpenBMB's remote code or llama.cpp-omni, and 28 GB of GPU for the full demo. The main risks are repository code and pickle files and no safety results.

Nemotron 3 Nano Omni 30B A3B Reasoning

A local multimodal cousin for video with speech, long documents, charts, screens and English transcription, with tool calling, a reasoning switch and a 262,144-token context. It needs about 27 GB for NVIDIA's NVFP4 build on Blackwell, or 42 GB for FP8. The main risks are the remote code it loads and a repository where nobody answers questions.

MiniCPM-o 4.5

1. Quickest start for text and images is ollama run openbmb/minicpm-o4.5, about 6 GB
2. With vLLM 0.16.0 or later pass --trust-remote-code, and send stop_token_ids [151643, 151645] as OpenBMB's guide does
3. vLLM, llama.cpp and Ollama return text only; for speech out use the card's Transformers 4.51.0 code or OpenBMB's llama.cpp-omni
4. In llama.cpp pass both the language GGUF and MiniCPM-o-4_5-vision-F16.gguf with --mmproj, and use --jinja --reasoning-budget 0 to turn thinking off
5. Keep prompts within 40,960 tokens
6. Don't rely on tool calls or JSON output, neither is documented; validate any you get

Nemotron 3 Nano Omni 30B A3B Reasoning

1. Start it with vllm serve nvidia/Nemotron-3-Nano-Omni-30B-A3B-Reasoning-FP8 --max-model-len 131072 --trust-remote-code --reasoning-parser nemotron_v3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --kv-cache-dtype fp8 on vLLM 0.20.0 or later, after pip install "vllm[audio]" if any audio will be sent
2. Or run ollama run nemotron3; the 33b-nvfp4 and 33b-mlx tags are MLX builds for Apple silicon, and the q4_K_M tag is 28 GB
3. Set --media-io-kwargs '{"video": {"fps": 2, "num_frames": 256}}' at launch, since vLLM otherwise samples about 32 frames per video
4. Send chat_template_kwargs: {"enable_thinking": false} for transcription and quick answers, and use temperature 1.0 with top_k 1 for ASR as the card recommends
5. Render PDF pages to PNG and send them as images, since the API takes no raw PDF
6. Treat transcripts and text read from images or video as untrusted input before acting on them