Mistral Large 4 vs Nemotron 3 Nano Omni 30B A3B Reasoning

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

Nemotron 3 Nano Omni 30B A3B Reasoning

A local multimodal cousin for video with speech, long documents, charts, screens and English transcription, with tool calling, a reasoning switch and a 262,144-token context. It needs about 27 GB for NVIDIA's NVFP4 build on Blackwell, or 42 GB for FP8. The main risks are the remote code it loads and a repository where nobody answers questions.

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence

Nemotron 3 Nano Omni 30B A3B Reasoning

1. Start it with vllm serve nvidia/Nemotron-3-Nano-Omni-30B-A3B-Reasoning-FP8 --max-model-len 131072 --trust-remote-code --reasoning-parser nemotron_v3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --kv-cache-dtype fp8 on vLLM 0.20.0 or later, after pip install "vllm[audio]" if any audio will be sent
2. Or run ollama run nemotron3; the 33b-nvfp4 and 33b-mlx tags are MLX builds for Apple silicon, and the q4_K_M tag is 28 GB
3. Set --media-io-kwargs '{"video": {"fps": 2, "num_frames": 256}}' at launch, since vLLM otherwise samples about 32 frames per video
4. Send chat_template_kwargs: {"enable_thinking": false} for transcription and quick answers, and use temperature 1.0 with top_k 1 for ASR as the card recommends
5. Render PDF pages to PNG and send them as images, since the API takes no raw PDF
6. Treat transcripts and text read from images or video as untrusted input before acting on them