Mistral Large 4 vs NVIDIA Nemotron 3.5 Bolt E4B 4GB

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

NVIDIA Nemotron 3.5 Bolt E4B 4GB

A small cousin for voice and device assistants, game characters and robot interfaces, trained for multi-turn tool calls, instruction hierarchy and short spoken replies, with thinking switchable per request. NVIDIA's Q4_K_M GGUF needs about 8 GB, and Ollama and LM Studio carry it. Context is 64K, half the Gemma 4 base, and NVIDIA publishes no safety results.

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence

NVIDIA Nemotron 3.5 Bolt E4B 4GB

1. Quickest start is ollama run nemotron-3.5-bolt:e4b, about 8 GB of files, and set num_ctx to 65536 or less, since NVIDIA supports 64K
2. With NVIDIA's GGUF use llama-server -m Nemotron-3.5-Bolt-E4B-Q4_K_M.gguf -c 65536 -ngl 999 --jinja, and add --reasoning on --reasoning-budget <tokens> to cap thinking
3. With vLLM 0.31.0 or later pass --enable-auto-tool-choice --tool-call-parser gemma4 --reasoning-parser gemma4 and the repository's chat_template.jinja
4. Pass enable_thinking explicitly in chat_template_kwargs, since the template defaults to off whatever the card says, and set skip_special_tokens false as the card's examples do
5. Use temperature=1.0 and top_p=0.95 in both modes, as the card says
6. Set conversational_mode true for spoken replies, which appends a brevity instruction to the system prompt
7. Answer a slow tool at once with a pending tool message, then send the result later as a user message starting TOOL RESULT, as the card's asynchronous pattern says
8. Keep persistent rules in the system prompt and send state updates as separate user or system messages in order, per the card's prompting guidelines