Mistral Large 4 vs Qwen3.5-4B

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

Qwen3.5-4B

A small vision-language cousin for tool calls, light agent steps and image or video reading on almost any machine, with switchable thinking. Ollama's 3.3 GB build or the 9.3 GB BF16 files run in every major runtime under plain Apache 2.0. The main risks are no safety results, no structured-output guarantee and no answers from Alibaba since March.

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence

Qwen3.5-4B

1. Smallest start is ollama run qwen3.5:4b (Q4_K_M, about 4 GB with context)
2. Full precision vllm serve Qwen/Qwen3.5-4B --port 8000 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder
3. Turn thinking off with "chat_template_kwargs": {"enable_thinking": false} in the request body, since it's on by default and /think and /nothink aren't supported
4. There's no generation_config.json, so pass the card's sampling yourself, for example temperature=0.7, top_p=0.8, top_k=20, presence_penalty=1.5 without thinking
5. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
6. Validate any JSON it returns, since structured output isn't documented