Gemma 4 26B A4B IT vs Mistral Large 4

Gemma 4 26B A4B IT

A fast mixture-of-experts cousin for general agent work with tools, optional thinking and image input, under Apache 2.0. Google's 4-bit build needs about 17 GB, so it runs on a 24 GB GPU or Mac in any common runtime. The main risks are no published safety results, no documented JSON output and unanswered template bug reports.

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

Gemma 4 26B A4B IT

1. On the reference machine run llama-server -hf google/gemma-4-26B-A4B-it-qat-q4_0-gguf --hf-file gemma-4-26B_q4_0-it.gguf --jinja -c 65536, and add the mmproj file for images
2. With Ollama run ollama run gemma4:26b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since Google's guide says it defaults to 4K below 24 GiB of VRAM and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Validate tool names and arguments before running them, and check any JSON yourself

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence