Mistral Large 4 vs Qwen3.6-35B-A3B

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

Qwen3.6-35B-A3B

A fast mixture-of-experts cousin with 3B active parameters for coding and tool calling, with image and video input, in every major runtime under plain Apache 2.0. Ollama's 4-bit build needs about 28 GB. The main risk is that nobody at Alibaba maintains it, with no safety results, no security contact and no replies to tool-calling reports.

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence

Qwen3.6-35B-A3B

1. Start it with ollama run qwen3.6:35b (Q4_K_M, 23 to 24 GB on disk, about 28 GB in memory)
2. On the reference machine use vllm serve Qwen/Qwen3.6-35B-A3B --max-model-len 131072 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, BF16, since vLLM doesn't document FP8 compute on gfx1151
3. Use the qwen3_coder tool-call parser and the qwen3 reasoning parser in vLLM 0.19.0 or SGLang 0.5.10 or later
4. Thinking is on by default and /nothink isn't supported, so pass enable_thinking as false in chat_template_kwargs for short tasks, or preserve_thinking as true to keep earlier reasoning
5. Card sampling for thinking is temperature 1.0, top_p 0.95, top_k 20, presence_penalty 1.5, and for non-thinking temperature 0.7, top_p 0.8
6. Keep at least 128K of context as the card advises, and turn on YaRN only beyond 262,144 tokens
7. Validate JSON output yourself or use the runtime's guided decoding, since the model card documents none