Mistral Large 4 vs Qwen3-VL-4B-Instruct

Mistral Large 4

A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.

Qwen3-VL-4B-Instruct

A small vision-language cousin for reading screenshots, documents, charts and video, running in about 3.5 GB from Alibaba's Q4_K_M GGUF in every major runtime under plain Apache 2.0. It has no thinking mode, and Qwen hasn't answered repository questions or published safety work, so add your own guardrails before letting it drive a GUI.

Mistral Large 4

1. Serve the NVFP4 build on Blackwell with vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice; released vLLM doesn't load it
2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe
3. Pass reasoning_effort low, medium or high (default high); any other value makes the template raise an error, and there is no off switch
4. Read the reasoning from message.reasoning; max_completion_tokens counts reasoning tokens too
5. Use temperature 1.0 and top_p 0.95 at every effort, per the card
6. Ask for JSON with response_format type json_schema and strict true; the template passes the schema to the model
7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message
8. Add --speculative-config '{"method": "dspark", "num_speculative_tokens": 3}' to use the embedded draft head
9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence

Qwen3-VL-4B-Instruct

1. Start it with llama-server -hf Qwen/Qwen3-VL-4B-Instruct-GGUF:Q4_K_M --jinja -c 32768, or ollama run qwen3-vl:4b-instruct
2. In Ollama the plain qwen3-vl:4b tag is the Thinking edition, so name 4b-instruct
3. With the GGUF, load the mmproj vision file too, or images won't be read
4. Parse tool calls as JSON inside <tool_call> tags, or use SGLang's --tool-call-parser qwen
5. Use the card's sampling, temperature=0.7, top_p=0.8, top_k=20, presence_penalty=1.5 for vision and temperature=1.0, top_p=1.0, top_k=40, presence_penalty=2.0 for text
6. Validate JSON output yourself, since structured output isn't documented
7. vLLM needs 0.11.0 or later and Transformers 4.57.0 or later