Qwen3.5-397B-A17B vs Qwen3.6-35B-A3B

Qwen3.5-397B-A17B

Alibaba's biggest open Qwen3.5, a cousin for hard coding, agent and vision work. Even at 4 bits it needs about 270 GB, so most agents will call it through Alibaba's Model Studio or one of the many providers that host it. The main risk is silence, with no safety results, no agent guidance and template reports without a reply.

Qwen3.6-35B-A3B

A fast mixture-of-experts cousin with 3B active parameters for coding and tool calling, with image and video input, in every major runtime under plain Apache 2.0. Ollama's 4-bit build needs about 28 GB. The main risk is that nobody at Alibaba maintains it, with no safety results, no security contact and no replies to tool-calling reports.

Qwen3.5-397B-A17B

1. The card's server command is vllm serve Qwen/Qwen3.5-397B-A17B --port 8000 --tensor-parallel-size 8 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, and the FP8 build halves the memory
2. It doesn't fit our 128 GB reference machine at any precision, so call a hosted endpoint instead (Model Studio's Qwen3.5-Plus, or a provider serving Qwen/Qwen3.5-397B-A17B)
3. On Model Studio pass "enable_thinking": false directly, while vLLM and SGLang take "chat_template_kwargs": {"enable_thinking": false}
4. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
5. For multi-token prediction in vLLM add --speculative-config '{"method":"qwen3_next_mtp","num_speculative_tokens":2}'
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Validate any JSON it returns, since structured output isn't documented

Qwen3.6-35B-A3B

1. Start it with ollama run qwen3.6:35b (Q4_K_M, 23 to 24 GB on disk, about 28 GB in memory)
2. On the reference machine use vllm serve Qwen/Qwen3.6-35B-A3B --max-model-len 131072 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, BF16, since vLLM doesn't document FP8 compute on gfx1151
3. Use the qwen3_coder tool-call parser and the qwen3 reasoning parser in vLLM 0.19.0 or SGLang 0.5.10 or later
4. Thinking is on by default and /nothink isn't supported, so pass enable_thinking as false in chat_template_kwargs for short tasks, or preserve_thinking as true to keep earlier reasoning
5. Card sampling for thinking is temperature 1.0, top_p 0.95, top_k 20, presence_penalty 1.5, and for non-thinking temperature 0.7, top_p 0.8
6. Keep at least 128K of context as the card advises, and turn on YaRN only beyond 262,144 tokens
7. Validate JSON output yourself or use the runtime's guided decoding, since the model card documents none