Nemotron 3 Nano 4B vs Qwen3.5-397B-A17B

Nemotron 3 Nano 4B

A tiny reasoning cousin with trained tool calls, a thinking switch and 262,144 tokens of context, running in about 4 GB from NVIDIA's own GGUF on almost any machine. The main risks are serving commands that run repository code, no published safety results, a tool format left to the template, and files untouched and questions unanswered since March.

Qwen3.5-397B-A17B

Alibaba's biggest open Qwen3.5, a cousin for hard coding, agent and vision work. Even at 4 bits it needs about 270 GB, so most agents will call it through Alibaba's Model Studio or one of the many providers that host it. The main risk is silence, with no safety results, no agent guidance and template reports without a reply.

Nemotron 3 Nano 4B

1. Quickest start is ollama run nemotron-3-nano:4b, a 2.8 GB build
2. With llama.cpp use llama-server -hf nvidia/NVIDIA-Nemotron-3-Nano-4B-GGUF --jinja, NVIDIA's own Q4_K_M file
3. With vLLM, download nano_v3_reasoning_parser.py from the repository first and serve with --enable-auto-tool-choice --tool-call-parser qwen3_coder --reasoning-parser-plugin nano_v3_reasoning_parser.py --reasoning-parser nano_v3
4. The card's Transformers snippet names nvidia/NVIDIA-Nemotron-3-Nano-4B, use nvidia/NVIDIA-Nemotron-3-Nano-4B-BF16 instead
5. Thinking is on by default. Pass enable_thinking=False to the chat template for short tasks
6. Use temperature 1.0 and top_p 0.95 for reasoning and temperature 0.6 with top_p 0.95 for tool calling, as the card says
7. It's tuned for English only, and validate JSON yourself, since structured output isn't documented

Qwen3.5-397B-A17B

1. The card's server command is vllm serve Qwen/Qwen3.5-397B-A17B --port 8000 --tensor-parallel-size 8 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, and the FP8 build halves the memory
2. It doesn't fit our 128 GB reference machine at any precision, so call a hosted endpoint instead (Model Studio's Qwen3.5-Plus, or a provider serving Qwen/Qwen3.5-397B-A17B)
3. On Model Studio pass "enable_thinking": false directly, while vLLM and SGLang take "chat_template_kwargs": {"enable_thinking": false}
4. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
5. For multi-token prediction in vLLM add --speculative-config '{"method":"qwen3_next_mtp","num_speculative_tokens":2}'
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Validate any JSON it returns, since structured output isn't documented