Nemotron 3 Ultra 550B A55B vs Qwen3.5-397B-A17B

Nemotron 3 Ultra 550B A55B

NVIDIA's frontier-scale agent cousin with trained parallel tool calls, up to a 1M-token context and training against prompt injection through tool output. It needs at least four Blackwell GPUs for the 352 GB NVFP4 build, so most agents will use NVIDIA's API or a provider. The main risks are serving commands that run repository code and no published safety results.

Qwen3.5-397B-A17B

Alibaba's biggest open Qwen3.5, a cousin for hard coding, agent and vision work. Even at 4 bits it needs about 270 GB, so most agents will call it through Alibaba's Model Studio or one of the many providers that host it. The main risk is silence, with no safety results, no agent guidance and template reports without a reply.

Nemotron 3 Ultra 550B A55B

1. It doesn't fit the 128 GB reference machine at any precision. Call NVIDIA's API (model nvidia/nemotron-3-ultra-550b-a55b) or a provider instead
2. With vLLM serve the NVFP4 build with --trust-remote-code --reasoning-parser nemotron_v3 --enable-auto-tool-choice --tool-call-parser qwen3_coder on 4 × B200 or more
3. With SGLang use --reasoning-parser nemotron_3, not the BF16 card's nemotron_v3, which SGLang doesn't register
4. On SGLang with tools, pass chat_template_kwargs with enable_thinking true and force_nonempty_content true, as the card says, or reasoning and calls won't both parse
5. Thinking is on by default. Pass enable_thinking: false for short tasks or medium_effort: true to cut reasoning tokens
6. Use temperature=1.0 and top_p=0.95, as the generation config sets

Qwen3.5-397B-A17B

1. The card's server command is vllm serve Qwen/Qwen3.5-397B-A17B --port 8000 --tensor-parallel-size 8 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, and the FP8 build halves the memory
2. It doesn't fit our 128 GB reference machine at any precision, so call a hosted endpoint instead (Model Studio's Qwen3.5-Plus, or a provider serving Qwen/Qwen3.5-397B-A17B)
3. On Model Studio pass "enable_thinking": false directly, while vLLM and SGLang take "chat_template_kwargs": {"enable_thinking": false}
4. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
5. For multi-token prediction in vLLM add --speculative-config '{"method":"qwen3_next_mtp","num_speculative_tokens":2}'
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Validate any JSON it returns, since structured output isn't documented