Gemma 4 E2B IT vs Nemotron 3 Ultra 550B A55B

Gemma 4 E2B IT

A small cousin for light agent work, tool-calling loops, transcription and image reading on a phone or laptop, under Apache 2.0. Google's 4-bit build needs about 5 GB with working space and runs in all the common runtimes. Google's card puts it far below larger Gemma 4 sizes on agent and coding tasks, with no published safety results.

Nemotron 3 Ultra 550B A55B

NVIDIA's frontier-scale agent cousin with trained parallel tool calls, up to a 1M-token context and training against prompt injection through tool output. It needs at least four Blackwell GPUs for the 352 GB NVFP4 build, so most agents will use NVIDIA's API or a provider. The main risks are serving commands that run repository code and no published safety results.

Gemma 4 E2B IT

1. On the reference machine run llama-server -hf google/gemma-4-E2B-it-qat-q4_0-gguf --hf-file gemma-4-E2B_q4_0-it.gguf --jinja -c 131072, and add --mmproj with gemma-4-E2B-it-mmproj.gguf for images and audio
2. With Ollama run ollama run gemma4:e2b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since the default context is small and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text; Google's w4a16 build is the 4-bit route there
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Put images before the text and audio after it, keep audio to 30 seconds and video to 60 frames, and validate tool names and arguments before running them

Nemotron 3 Ultra 550B A55B

1. It doesn't fit the 128 GB reference machine at any precision. Call NVIDIA's API (model nvidia/nemotron-3-ultra-550b-a55b) or a provider instead
2. With vLLM serve the NVFP4 build with --trust-remote-code --reasoning-parser nemotron_v3 --enable-auto-tool-choice --tool-call-parser qwen3_coder on 4 × B200 or more
3. With SGLang use --reasoning-parser nemotron_3, not the BF16 card's nemotron_v3, which SGLang doesn't register
4. On SGLang with tools, pass chat_template_kwargs with enable_thinking true and force_nonempty_content true, as the card says, or reasoning and calls won't both parse
5. Thinking is on by default. Pass enable_thinking: false for short tasks or medium_effort: true to cut reasoning tokens
6. Use temperature=1.0 and top_p=0.95, as the generation config sets