MiniCPM-o 4.5 vs Nemotron 3 Nano 30B A3B

MiniCPM-o 4.5

A small omni cousin that sees, listens and talks back, with full-duplex speech and voice cloning, in about 7 GB at 4-bit through llama.cpp or Ollama for text and images. Speech output needs OpenBMB's remote code or llama.cpp-omni, and 28 GB of GPU for the full demo. The main risks are repository code and pickle files and no safety results.

Nemotron 3 Nano 30B A3B

A fast hybrid Mamba-Transformer cousin with 3.5B active parameters for reasoning and tool calling over very long inputs, in every major local runtime. A 4-bit build needs about 22 to 23 GB. The main risks are that NVIDIA's documented vLLM path runs repository code, no safety results are published and NVIDIA hasn't answered reports since March.

MiniCPM-o 4.5

1. Quickest start for text and images is ollama run openbmb/minicpm-o4.5, about 6 GB
2. With vLLM 0.16.0 or later pass --trust-remote-code, and send stop_token_ids [151643, 151645] as OpenBMB's guide does
3. vLLM, llama.cpp and Ollama return text only; for speech out use the card's Transformers 4.51.0 code or OpenBMB's llama.cpp-omni
4. In llama.cpp pass both the language GGUF and MiniCPM-o-4_5-vision-F16.gguf with --mmproj, and use --jinja --reasoning-budget 0 to turn thinking off
5. Keep prompts within 40,960 tokens
6. Don't rely on tool calls or JSON output, neither is documented; validate any you get

Nemotron 3 Nano 30B A3B

1. Start it with ollama run nemotron-3-nano:30b (18 GB MLX on a Mac, 24 GB q4_K_M elsewhere)
2. On the reference machine use BF16 with vLLM, after wget https://huggingface.co/nvidia/NVIDIA-Nemotron-3-Nano-30B-A3B-BF16/resolve/main/nano_v3_reasoning_parser.py, then vllm serve nvidia/NVIDIA-Nemotron-3-Nano-30B-A3B-BF16 --max-model-len 262144 --trust-remote-code --enable-auto-tool-choice --tool-call-parser qwen3_coder --reasoning-parser-plugin nano_v3_reasoning_parser.py --reasoning-parser nano_v3
3. NVFP4 needs an NVIDIA Blackwell GPU, and FP8 isn't documented on gfx1151
4. Without the qwen3_coder tool parser and the nano_v3 reasoning parser, tool calls and reasoning come back as plain text
5. Card sampling is temperature 0.6 and top_p 0.95 for tool calling, temperature 1.0 and top_p 1.0 for reasoning
6. Thinking is on by default, so pass enable_thinking as false in chat_template_kwargs for short tasks
7. Set VLLM_ALLOW_LONG_MAX_MODEL_LEN=1 and raise --max-model-len only when you need more than 262,144 tokens
8. In SGLang the main branch names the reasoning parser nemotron_3, not the card's nano_v3
9. Filter untrusted tool results before they reach the model, as NVIDIA warns prompt injection can lead to code execution
10. Validate JSON output yourself or use the runtime's guided decoding, since none is documented for the model