Agents-A1-4B vs Qwen3.5-122B-A10B

Agents-A1-4B

A small agent cousin for search, research and tool-calling loops, with vision and 262,144 tokens of context. It runs in about 4 GB from InternScience's Q4_K_M GGUF, in vLLM, SGLang, Transformers or llama.cpp. The main risks are an undeclared base, no safety results or agent guidance, and a template that adds its own dated system prompt when you send none.

Qwen3.5-122B-A10B

A strong mid-size cousin for coding, agent steps and reading images or video, with thinking you can switch off per request. Alibaba's 4-bit build needs about 95 GB, which fits one 128 GB unified-memory machine, and several providers host it. The main risk is silence, with no safety results, agent guidance or answers from Alibaba.

Agents-A1-4B

1. Quickest start is llama-server -hf InternScience/Agents-A1-4B-Q4_K_M-GGUF --jinja, about 3.4 GB with the vision projector
2. With vLLM use --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder, as on the card, and add --language-model-only for text-only work
3. Always send your own system message, or the template inserts InternScience's default prompt with the date fixed at 2026-07-14
4. The card recommends temperature 0.85, top_p 0.95, top_k 20, min_p 0 and presence_penalty 1.1, and there is no generation_config.json to set them
5. Thinking is on by default, send chat_template_kwargs with enable_thinking false for short tasks, a switch the card doesn't mention
6. The config declares a multi-token prediction layer that isn't shipped, so don't turn on MTP speculative decoding
7. Validate JSON output yourself, since structured output isn't documented

Qwen3.5-122B-A10B

1. Quickest start on a 128 GB machine is ollama run qwen3.5:122b (Q4_K_M, 81 GB of files, about 97 GB with context)
2. Alibaba's 4-bit build serves with vllm serve Qwen/Qwen3.5-122B-A10B-GPTQ-Int4 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --quantization moe_wna16, though that kernel isn't documented for AMD gfx1151
3. Use the qwen3_coder tool parser and the qwen3 reasoning parser, as the card's commands do
4. Turn thinking off with "chat_template_kwargs": {"enable_thinking": false} in the request body, since it's on by default and /think and /nothink aren't supported
5. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Add --language-model-only in vLLM to skip the vision encoder and free memory for the KV cache when you only need text
8. Validate any JSON it returns, since structured output isn't documented