Gemma 4 12B IT vs Qwen3.5-122B-A10B

Gemma 4 12B IT

A mid-size cousin for agent work with tools, optional thinking and image and audio input, under Apache 2.0. Google's 4-bit build needs under 9 GB with working space, so it runs on a 12 GB GPU or any recent Mac in all the common runtimes. The main risks are no published safety results and no documented JSON output.

Qwen3.5-122B-A10B

A strong mid-size cousin for coding, agent steps and reading images or video, with thinking you can switch off per request. Alibaba's 4-bit build needs about 95 GB, which fits one 128 GB unified-memory machine, and several providers host it. The main risk is silence, with no safety results, agent guidance or answers from Alibaba.

Gemma 4 12B IT

1. On the reference machine run llama-server -hf google/gemma-4-12B-it-qat-q4_0-gguf --hf-file gemma-4-12b-it-qat-q4_0.gguf --jinja -c 131072, and add --mmproj with mmproj-gemma-4-12b-it-qat-q4_0.gguf for images and audio
2. With Ollama run ollama run gemma4:12b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since the default context is small and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text; Google's w4a16 build is the 4-bit route there
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Put images before the text and audio after it, keep audio to 30 seconds and video to 60 frames, and validate tool names and arguments before running them
6. Transformers needs 5.10.0 or later for gemma4_unified, and mlx-lm has no gemma4_unified code, so on a Mac use mlx-vlm, LM Studio or Ollama

Qwen3.5-122B-A10B

1. Quickest start on a 128 GB machine is ollama run qwen3.5:122b (Q4_K_M, 81 GB of files, about 97 GB with context)
2. Alibaba's 4-bit build serves with vllm serve Qwen/Qwen3.5-122B-A10B-GPTQ-Int4 --max-model-len 262144 --reasoning-parser qwen3 --enable-auto-tool-choice --tool-call-parser qwen3_coder --quantization moe_wna16, though that kernel isn't documented for AMD gfx1151
3. Use the qwen3_coder tool parser and the qwen3 reasoning parser, as the card's commands do
4. Turn thinking off with "chat_template_kwargs": {"enable_thinking": false} in the request body, since it's on by default and /think and /nothink aren't supported
5. Sampling per the card is temperature 0.6, top_p 0.95 and top_k 20 when thinking, and temperature 0.7, top_p 0.8, top_k 20 and presence_penalty 1.5 without
6. Keep the context at 128K or more if you rely on thinking, and turn on YaRN only past 262,144 tokens
7. Add --language-model-only in vLLM to skip the vision encoder and free memory for the KV cache when you only need text
8. Validate any JSON it returns, since structured output isn't documented