Gemma 4 12B IT vs Gemma 4 E4B IT

Gemma 4 12B IT

A mid-size cousin for agent work with tools, optional thinking and image and audio input, under Apache 2.0. Google's 4-bit build needs under 9 GB with working space, so it runs on a 12 GB GPU or any recent Mac in all the common runtimes. The main risks are no published safety results and no documented JSON output.

Gemma 4 E4B IT

A small cousin for light agent work, tool-calling loops, transcription and image reading on a phone or laptop, under Apache 2.0. Google's 4-bit build needs about 7 GB with working space and runs in all the common runtimes. Google's card puts it far below larger Gemma 4 sizes on agent and coding tasks, with no published safety results.

Gemma 4 12B IT

1. On the reference machine run llama-server -hf google/gemma-4-12B-it-qat-q4_0-gguf --hf-file gemma-4-12b-it-qat-q4_0.gguf --jinja -c 131072, and add --mmproj with mmproj-gemma-4-12b-it-qat-q4_0.gguf for images and audio
2. With Ollama run ollama run gemma4:12b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since the default context is small and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text; Google's w4a16 build is the 4-bit route there
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Put images before the text and audio after it, keep audio to 30 seconds and video to 60 frames, and validate tool names and arguments before running them
6. Transformers needs 5.10.0 or later for gemma4_unified, and mlx-lm has no gemma4_unified code, so on a Mac use mlx-vlm, LM Studio or Ollama

Gemma 4 E4B IT

1. On the reference machine run llama-server -hf google/gemma-4-E4B-it-qat-q4_0-gguf --hf-file gemma-4-E4B_q4_0-it.gguf --jinja -c 131072, and add --mmproj with gemma-4-E4B-it-mmproj.gguf for images and audio
2. With Ollama run ollama run gemma4:e4b and raise num_ctx or OLLAMA_CONTEXT_LENGTH, since the default context is small and agents want at least 64K
3. In vLLM or SGLang pass --tool-call-parser gemma4 --reasoning-parser gemma4 (vLLM also --enable-auto-tool-choice), or tool calls come back as text; Google's w4a16 build is the 4-bit route there
4. Thinking is off by default; pass enable_thinking=True or start the system prompt with <|think|>, and drop earlier turns' thinking from history except on tool-call turns
5. Put images before the text and audio after it, keep audio to 30 seconds and video to 60 frames, and validate tool names and arguments before running them