# Carbon-X vs Laguna XS 2.1

> Carbon-X and Laguna XS 2.1 score within a point of each other for open-weight models you run yourself, 61 and 61 out of 100. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1
- Markdown: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.md (~6,000 tokens)
- Slim: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.min.md (~480 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

Carbon-X and Laguna XS 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna XS 2.1 leads on agent interface. Both do open-weight models you run yourself.

- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- Laguna XS 2.1: grade C, 61/100, rank #42 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/laguna-xs-2-1.md · JSON https://www.anchorterminal.com/api/v1/tools/laguna-xs-2-1.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Reach, 90 against 85
- Risk, 65 against 55
- Documentation and upkeep, 77 against 46

Watch for: Not clinically validated and no wet-lab validation reported

### Laguna XS 2.1 (C)

Good for: Agents that want a fast local coding model on a 32 GB GPU or Mac, with tool calling and a permissive licence.

Ahead on:
- Agent interface, 85 against 35

Watch for: No reply from Poolside to any discussion, including reports about the tokenizer and remote code


## Score by category

| Category | Weight | Carbon-X | Laguna XS 2.1 | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 85 | Carbon-X +5 |
| Risk | 20% (20 this run) | 65 | 55 | Carbon-X +10 |
| Agent interface | 10% (10 this run) | 35 | 85 | Laguna XS 2.1 +50 |
| Documentation and upkeep | 10% (10 this run) | 77 | 46 | Carbon-X +31 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **61 · C** | |

## Facts side by side

| Fact | Carbon-X | Laguna XS 2.1 |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | Hugging Face (HuggingFaceBio) | Poolside |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | OpenMDW-1.1 |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-10-22 | 2026-08-19 |
| Terms last updated | no document linked |  |
| Privacy policy last updated | no document linked |  |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 2.8/5 (4) |

## Verdicts

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

**Laguna XS 2.1.** A small coding and agent cousin with 3B active parameters, so it's quick on modest hardware. Poolside's 4-bit GGUF, also Ollama's default, needs about 24 GB, and every major runtime runs it. The main risks are that nobody at Poolside answers its discussions, there are no safety results, and the SGLang route runs repository code.

## Before you call either

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

### Laguna XS 2.1

1. Quickest start is `ollama run laguna-xs-2.1`, 20 GB of files, the same Q4_K_M as Poolside's GGUF
2. On our reference machine use `llama-server -hf poolside/Laguna-XS-2.1-GGUF:Q4_K_M --jinja -c 131072`, from a llama.cpp release with the laguna architecture (b11772 has it), or BF16 with vLLM (66.9 GB)
3. With vLLM use `--tool-call-parser poolside_v1 --reasoning-parser poolside_v1 --enable-auto-tool-choice`, on a build with vllm-project/vllm#47311, or `--tool-call-parser glm47` on older builds
4. Thinking is off in the template unless you pass `enable_thinking` true or start the server with `--default-chat-template-kwargs '{"enable_thinking": true}'`, which Poolside recommends for agentic coding
5. Pass earlier reasoning back as `reasoning_content` in the history, since the card says reasoning may stop in later steps if it's dropped
6. Sampling per the card is temperature 1.0 and top_k 20
7. The card warns that Ollama on Apple Silicon may return empty output until llama.cpp#25389 ships
8. Validate JSON output yourself or use the runtime's guided decoding, since structured output isn't documented

## Questions

### Which is better for AI agents, Carbon-X or Laguna XS 2.1?

Carbon-X and Laguna XS 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna XS 2.1 leads on agent interface.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "carbon-x", "b": "laguna-xs-2-1"}`. From a terminal: `anchor compare carbon-x laguna-xs-2-1`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/laguna-xs-2-1.json

## Other comparisons with Carbon-X or Laguna XS 2.1

- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)
- [Agents-A1-4B vs Laguna XS 2.1](https://www.anchorterminal.com/compare/agents-a1-4b-vs-laguna-xs-2-1.md)
- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)
- [Apertus v1.5 8B vs Laguna XS 2.1](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-laguna-xs-2-1.md)
- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)
- [Apodex-1.1-mini vs Laguna XS 2.1](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-laguna-xs-2-1.md)
- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)
- [BigBang-v1 vs Laguna XS 2.1](https://www.anchorterminal.com/compare/bigbang-v1-vs-laguna-xs-2-1.md)
- [Carbon-X vs Cosmos-Reason2-2B](https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.md)
- [Carbon-X vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md)
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- [Laguna XS 2.1 vs ThinkingCap (Qwen3.8 27B)](https://www.anchorterminal.com/compare/laguna-xs-2-1-vs-thinkingcap-qwen3-8-27b.md)

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