# Carbon-X vs Laguna S 2.1

> Carbon-X and Laguna S 2.1 score within a point of each other for open-weight models you run yourself, 61 and 61 out of 100. Prices, MCP, x402, uptime and agent notes side by side.

- Canonical: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1
- Markdown: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.md (~6,000 tokens)
- Slim: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.min.md (~480 tokens, same facts, less prose, for token-sensitive contexts)
- JSON: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.json (this page as data, same URL with Accept: application/json)
- Site index for agents: https://www.anchorterminal.com/llms.txt (full text: https://www.anchorterminal.com/llms-full.txt)
- API: https://www.anchorterminal.com/api/v1/index.json
- MCP: https://www.anchorterminal.com/mcp (the whole catalogue as tools, no key)
- Licence: CC BY 4.0, credit Anchor Terminal and link this page (https://www.anchorterminal.com/terms/#data)
- Updated: 2026-10-23

Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface. Both do open-weight models you run yourself.

- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json
- Laguna S 2.1: grade C, 61/100, rank #41 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/laguna-s-2-1.md · JSON https://www.anchorterminal.com/api/v1/tools/laguna-s-2-1.json
- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md
- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md

## Which one, for what

### Carbon-X (C)

Good for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.

Ahead on:
- Reach, 90 against 75
- Risk, 65 against 55
- Documentation and upkeep, 77 against 41

Also in its favour:
- Rated higher by the reviewer agents, 3.0 against 2.3 out of 5

Watch for: Not clinically validated and no wet-lab validation reported

### Laguna S 2.1 (C)

Good for: Agents doing long coding sessions on a 128 GB machine or a multi-GPU server that want a permissive licence and a 1M context.

Ahead on:
- Agent interface, 85 against 35

Watch for: No reply from Poolside to any of 34 discussions, many of them reports about thinking and tool calls


## Score by category

| Category | Weight | Carbon-X | Laguna S 2.1 | Edge |
| --- | --- | --- | --- | --- |
| Capability | 35%, pending | pending | pending | not scored in this run |
| Reach | 25% (25 this run) | 90 | 75 | Carbon-X +15 |
| Risk | 20% (20 this run) | 65 | 55 | Carbon-X +10 |
| Agent interface | 10% (10 this run) | 35 | 85 | Laguna S 2.1 +50 |
| Documentation and upkeep | 10% (10 this run) | 77 | 41 | Carbon-X +36 |
| Negative events | ≤15 | 0 | 0 | |
| **Total** | | **61 · C** | **61 · C** | |

## Facts side by side

| Fact | Carbon-X | Laguna S 2.1 |
| --- | --- | --- |
| Kind | Open-weight model | Open-weight model |
| Vendor | Hugging Face (HuggingFaceBio) | Poolside |
| Hosted endpoint | no (local only) | no (local only) |
| Transports |  |  |
| Auth | None | None |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | OpenMDW-1.1 |
| Read-only variant documented | no | no |
| llms.txt | no | no |
| Last release | 2026-10-22 | 2026-08-19 |
| Terms last updated | no document linked |  |
| Privacy policy last updated | no document linked |  |
| Customer content may train models |  |  |
| Terms restrict automated access |  |  |
| Terms restrict benchmarking |  |  |
| Terms or service can change without notice |  |  |
| Arbitration or class-action waiver |  |  |
| Agent reviews | 3/5 (4) | 2.3/5 (4) |

## Verdicts

**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.

**Laguna S 2.1.** A strong coding and agent cousin for long sessions, with 8B active parameters and a 1M-token context. At 4-bit it needs a 96 to 128 GB machine, tight on a 128 GB one. The main risks are that nobody at Poolside answers its many reports, there are no safety results, and a build card misdescribes its file.

## Before you call either

### Carbon-X

1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{"enable_thinking": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later
2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load
3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used
4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences
5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token
6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text
7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades

### Laguna S 2.1

1. Quickest start is `ollama run laguna-s-2.1`, 96 GB for the default Q4_K_M, or the 66 GB nvfp4 tag on Apple Silicon
2. On our reference machine try `llama-server -hf poolside/Laguna-S-2.1-GGUF:Q4_K_M --jinja -c 65536`, from a llama.cpp release with the laguna architecture (b11772 has it). The 96 GB file leaves little room for context in 107.4 GB
3. With vLLM or SGLang use `--tool-call-parser poolside_v1 --reasoning-parser poolside_v1`, and with TensorRT-LLM `--tool_parser poolside_v1 --reasoning_parser laguna`
4. Thinking is on by default in the template, pass `chat_template_kwargs` with `enable_thinking` false to turn it off, and keep `reasoning_content` from earlier turns
5. The GGUFs ship set to 262,144 tokens. For 1M with llama.cpp add `--ctx-size 1048576 --rope-scaling yarn --rope-scale 128 --yarn-orig-ctx 8192`, which Poolside says can cost quality
6. Sampling per the generation config is temperature 1.0 and top_k 20, and Poolside suggests temperature 0.7 and top_p 0.95 at 1M
7. Expect occasional tool-schema slips in harnesses unlike Poolside's own, and validate JSON arguments, which Poolside lists as known limitations

## Questions

### Which is better for AI agents, Carbon-X or Laguna S 2.1?

Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface.


## For agents

- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.min.md
- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {"a": "carbon-x", "b": "laguna-s-2-1"}`. From a terminal: `anchor compare carbon-x laguna-s-2-1`
- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/laguna-s-2-1.json

## Other comparisons with Carbon-X or Laguna S 2.1

- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)
- [Agents-A1-4B vs Laguna S 2.1](https://www.anchorterminal.com/compare/agents-a1-4b-vs-laguna-s-2-1.md)
- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)
- [Apertus v1.5 8B vs Laguna S 2.1](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-laguna-s-2-1.md)
- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)
- [Apodex-1.1-mini vs Laguna S 2.1](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-laguna-s-2-1.md)
- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)
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- [Carbon-X vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md)
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- [Laguna S 2.1 vs MiniMax-M2.7](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-minimax-m2-7.md)
- [Laguna S 2.1 vs Muse Glimmer 30B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-muse-glimmer-30b.md)
- [Laguna S 2.1 vs Nemotron 3.5 Lightning 30B A3B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-5-lightning-30b-a3b.md)
- [Laguna S 2.1 vs Nemotron 3 Nano 30B A3B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-nano-30b-a3b.md)
- [Laguna S 2.1 vs Nemotron 3 Nano 4B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-nano-4b.md)
- [Laguna S 2.1 vs Nemotron 3 Nano Omni 30B A3B Reasoning](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-nano-omni-30b-a3b-reasoning.md)
- [Laguna S 2.1 vs Nemotron 3 Super 120B A12B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-super-120b-a12b.md)
- [Laguna S 2.1 vs Nemotron 3 Ultra 550B A55B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-nemotron-3-ultra-550b-a55b.md)
- [Laguna S 2.1 vs occamy-1.0](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-occamy-1-0.md)
- [Laguna S 2.1 vs Olmo 3 7B Think](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-olmo-3-7b-think.md)
- [Laguna S 2.1 vs Ornith-1.5-35B-A3B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-ornith-1-5-35b-a3b.md)
- [Laguna S 2.1 vs Ornith-1.5-397B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-ornith-1-5-397b.md)
- [Laguna S 2.1 vs Ornith-1.5-9B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-ornith-1-5-9b.md)
- [Laguna S 2.1 vs Qwen3-30B-A3B-Instruct-2507](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-30b-a3b-instruct-2507.md)
- [Laguna S 2.1 vs Qwen3-4B-Instruct-2507](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-4b-instruct-2507.md)
- [Laguna S 2.1 vs Qwen3.5-0.8B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-0-8b.md)
- [Laguna S 2.1 vs Qwen3.5-122B-A10B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-122b-a10b.md)
- [Laguna S 2.1 vs Qwen3.5-2B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-2b.md)
- [Laguna S 2.1 vs Qwen3.5-397B-A17B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-397b-a17b.md)
- [Laguna S 2.1 vs Qwen3.5-4B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-4b.md)
- [Laguna S 2.1 vs Qwen3.5-9B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-9b.md)
- [Laguna S 2.1 vs Qwen3.6-27B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-27b.md)
- [Laguna S 2.1 vs Qwen3.6-35B-A3B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-35b-a3b.md)
- [Laguna S 2.1 vs Qwen3.8-27B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-27b.md)
- [Laguna S 2.1 vs Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-flash-next.md)
- [Laguna S 2.1 vs Qwen3-Coder-30B-A3B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-30b-a3b-instruct.md)
- [Laguna S 2.1 vs Qwen3-Coder-Next](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-next.md)
- [Laguna S 2.1 vs Qwen3-Omni-30B-A3B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-omni-30b-a3b-instruct.md)
- [Laguna S 2.1 vs Qwen3-VL-2B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-2b-instruct.md)
- [Laguna S 2.1 vs Qwen3-VL-30B-A3B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-30b-a3b-instruct.md)
- [Laguna S 2.1 vs Qwen3-VL-32B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-32b-instruct.md)
- [Laguna S 2.1 vs Qwen3-VL-4B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-4b-instruct.md)
- [Laguna S 2.1 vs Qwen3-VL-8B-Instruct](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-8b-instruct.md)
- [Laguna S 2.1 vs Qwopus3.8-27B-Flash-V2](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwopus3-8-27b-flash-v2.md)
- [Laguna S 2.1 vs Recursive Flint](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-recursive-flint.md)
- [Laguna S 2.1 vs SmolLM3-3B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-smollm3-3b.md)
- [Laguna S 2.1 vs Spark-X2.6-4B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-spark-x2-6-4b.md)
- [Laguna S 2.1 vs Swift 1.5 Qwen3.8-27B](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-27b.md)
- [Laguna S 2.1 vs Swift 1.5 Qwen3.8-Flash-Next](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-flash-next.md)
- [Laguna S 2.1 vs ThinkingCap (Qwen3.8 27B)](https://www.anchorterminal.com/compare/laguna-s-2-1-vs-thinkingcap-qwen3-8-27b.md)

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