{
  "data": {
    "a": {
      "slug": "carbon-x",
      "name": "Carbon-X",
      "vendor": "Hugging Face (HuggingFaceBio)",
      "vendorUrl": "https://huggingface.co/HuggingFaceBio",
      "kind": "weights",
      "category": "open-weights",
      "summary": "Carbon-X is Hugging Face's open-weight 14.8B language model for DNA, a fine-tune of Qwen3-14B that reads raw DNA in a chat and answers in English about variant effects and regulatory regions, with a 40,960-token context, under Apache 2.0.",
      "url": "https://www.anchorterminal.com/tools/carbon-x",
      "markdownUrl": "https://www.anchorterminal.com/tools/carbon-x.md",
      "slimMarkdownUrl": "https://www.anchorterminal.com/tools/carbon-x.min.md",
      "jsonUrl": "https://www.anchorterminal.com/api/v1/tools/carbon-x.json",
      "repo": "https://huggingface.co/HuggingFaceBio/Carbon-X",
      "license": "Apache-2.0",
      "transports": [],
      "packages": [
        {
          "registry": "huggingface",
          "name": "HuggingFaceBio/Carbon-X"
        },
        {
          "registry": "huggingface",
          "name": "HuggingFaceBio/Carbon-X-GGUF"
        }
      ],
      "auth": "none",
      "authNotes": "The weights download from Hugging Face with no account, token or terms to accept. The Hub reports gated false for HuggingFaceBio/Carbon-X and HuggingFaceBio/Carbon-X-GGUF (checked 2026-10-23). The Python tokenizer fetches Qwen/Qwen3-4B-Base's tokenizer at a pinned revision on first load, which is also ungated.",
      "pricing": "free",
      "pricingNotes": "Free to download and use, commercial use included, under Apache 2.0, and the base Qwen3-14B is Apache 2.0 too. Hugging Face sells no per-call access to it and no inference provider serves it. Running it costs the hardware, 29.6 GB for the BF16 safetensors and 9.6 GB for the publisher's smallest GGUF, Q4_K_M (checked 2026-10-23).",
      "priceSummary": "Free",
      "where": "local",
      "x402": {
        "level": "no",
        "evidence": "Weights you download and run yourself, so there is nothing to pay per call and no payment protocol (checked 2026-10-23).",
        "endpoints": []
      },
      "toolCount": null,
      "popularity": {
        "githubStars": null,
        "npmWeekly": null,
        "pypiWeekly": null,
        "asOf": "2026-10-23"
      },
      "docsUrl": "https://huggingface.co/HuggingFaceBio/Carbon-X",
      "capabilities": [
        "model.open-weights"
      ],
      "tags": [
        "open-weights",
        "model",
        "dense",
        "dna",
        "genomics",
        "biology",
        "fine-tune",
        "apache-2.0",
        "safetensors",
        "gguf",
        "self-hosted"
      ],
      "lastRelease": "2026-10-22",
      "graded": true,
      "anchor": {
        "graded": true,
        "score": 61,
        "grade": "C",
        "agentReady": false,
        "rank": 0,
        "ranked": false,
        "notRankedWhy": "An open-weight model, graded by the open-weight checklist and ranked among open-weight models, not against tools",
        "rankOf": 1201,
        "categoryRank": 30,
        "methodology": "0.6",
        "run": "2026-10-01",
        "scores": {
          "interface": 35,
          "reach": 90,
          "risk": 65,
          "upkeep": 77
        },
        "pending": [
          "performance",
          "tasks"
        ],
        "assessment": {
          "confidence": "low",
          "date": "2026-10-23"
        },
        "negative": 0,
        "verdict": "A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.",
        "bestFor": "Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.",
        "strengths": [
          "Hugging Face's own GGUFs at four precisions, the smallest about 12 GB with a fifth added",
          "Runs in released llama.cpp, vLLM, SGLang and Transformers",
          "Apache 2.0 on the model and its Qwen3-14B base, nothing gated",
          "A ready-made skill, an OpenAI-style tool example and an Inspect example for calling it from another agent",
          "Mid-training data listed by source with shares of 302B tokens"
        ],
        "weaknesses": [
          "Not clinically validated and no wet-lab validation reported",
          "The Python tokenizer needs trust_remote_code, and llama.cpp before b11742 tokenizes DNA wrongly",
          "Not trained for tool calling, structured output or reasoning",
          "The card says llama.cpp is unsupported while the publisher's GGUF repository says it is",
          "No inference provider or hosted API, and no knowledge cut-off"
        ],
        "agentNotes": [
          "Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later",
          "With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load",
          "Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used",
          "Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences",
          "Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token",
          "Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text",
          "Cap max_tokens for next-base questions, long DNA generation is slow and degrades"
        ],
        "metrics": {
          "kind": "local",
          "measured": false
        },
        "reviewCount": 4,
        "avgRating": 3,
        "history": [
          {
            "basis": "public evidence",
            "confidence": "low",
            "grade": "C",
            "methodology": "0.6",
            "pending": [
              "performance",
              "tasks"
            ],
            "run": "2026-10-01",
            "runLabel": "October 2026 research run",
            "score": 61
          }
        ],
        "editorialScores": {
          "interface": 35,
          "reach": 90,
          "risk": 65,
          "upkeep": 77
        },
        "provenanceScore": 53,
        "checked": {
          "categories": {
            "interface": "2026-10-23",
            "reach": "2026-10-23",
            "risk": "2026-10-23",
            "upkeep": "2026-10-23"
          },
          "last": "2026-10-23",
          "oldest": "2026-10-23",
          "stale": false,
          "staleAfterDays": 90
        }
      },
      "connect": {
        "install": "# llama.cpp b11742 or later (older builds tokenize DNA wrongly):\nllama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja \\\n  --chat-template-kwargs '{\"enable_thinking\": false}' \\\n  --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0 --port 8080\n# or, with vLLM:\nvllm serve HuggingFaceBio/Carbon-X --trust-remote-code",
        "http": "curl http://localhost:8080/v1/chat/completions -H 'Content-Type: application/json' \\\n  -d '{\"messages\": [{\"role\": \"user\", \"content\": \"Is this sequence more likely coding or non-coding? ATGGCGCTGTGGATGCGCCTCCTG\"}]}'"
      },
      "letme": {
        "capability": "https://letme.dev/model.open-weights",
        "tool": "https://letme.dev/carbon-x"
      },
      "sameCompany": [
        "hugging-face-inference-endpoints",
        "smollm3-3b"
      ],
      "weights": {
        "trainedBy": "Hugging Face with Zhongguancun Academy and TIGEM / University of Naples Federico II",
        "builtOn": "Qwen/Qwen3-14B (vocabulary extension, mid-training, supervised fine-tune and GRPO; base Apache 2.0, declared in the card's metadata)",
        "params": "14.8B",
        "context": 40960,
        "goodFor": "A DNA specialist another agent calls, for variant-effect questions, regulatory regions and next-base prediction on raw DNA kept on local hardware.",
        "runtimes": [
          "llama.cpp",
          "vLLM",
          "SGLang",
          "Transformers"
        ],
        "builds": [
          {
            "name": "Carbon-X-GGUF Q4_K_M",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF",
            "who": "publisher",
            "precision": "q4_k_m",
            "sizeGB": 9.64,
            "memoryGB": 12,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "carbon-x-q4_k_m.gguf, 9,636,318,080 bytes. Embedding and output tensors stay at Q8_0. The publisher's own runs put it lowest of the builds on FrontierVEP (67.8) and NextBase (38.6)"
          },
          {
            "name": "Carbon-X-GGUF Q6_K",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF",
            "who": "publisher",
            "precision": "q6_k",
            "sizeGB": 12.56,
            "memoryGB": 16,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "carbon-x-q6_k.gguf, 12,555,946,880 bytes"
          },
          {
            "name": "Carbon-X-GGUF Q5_K_M",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF",
            "who": "publisher",
            "precision": "q5_k_m",
            "sizeGB": 11.05,
            "memoryGB": 16,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "carbon-x-q5_k_m.gguf, 11,051,895,680 bytes"
          },
          {
            "name": "Carbon-X-GGUF Q8_0",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF",
            "who": "publisher",
            "precision": "q8_0",
            "sizeGB": 15.76,
            "memoryGB": 24,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "carbon-x-q8_0.gguf, 15,755,742,080 bytes, the build the publisher recommends"
          },
          {
            "name": "Carbon-X",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X",
            "who": "publisher",
            "precision": "bf16",
            "sizeGB": 29.64,
            "memoryGB": 48,
            "format": "safetensors",
            "runsOn": [
              "vLLM",
              "Transformers"
            ],
            "note": "Needs trust_remote_code for the custom HybridDNATokenizer, and Transformers v5 or later. The card says it fits one 80 GB GPU"
          },
          {
            "name": "Carbon-X-GGUF BF16",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF",
            "who": "publisher",
            "precision": "bf16",
            "sizeGB": 29.65,
            "memoryGB": 48,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "carbon-x-bf16.gguf, 29,651,012,480 bytes. llama.cpp b11742 or later"
          }
        ],
        "run": "llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0 --port 8080",
        "runBuild": "Carbon-X-GGUF Q8_0",
        "checked": "2026-10-23",
        "minMemoryGB": 12
      },
      "family": {
        "lab": "Hugging Face (Carbon)",
        "family": "Carbon",
        "url": "https://www.anchorterminal.com/open-weights/#huggingface-bio",
        "others": [
          {
            "name": "Carbon-A-1.2B",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-A-1.2B",
            "params": "1.2B"
          },
          {
            "name": "Carbon-8B",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-8B",
            "params": "8.3B"
          },
          {
            "name": "Carbon-3B",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-3B",
            "params": "3.5B"
          },
          {
            "name": "Carbon-500M",
            "url": "https://huggingface.co/HuggingFaceBio/Carbon-500M",
            "params": "0.5B"
          }
        ]
      },
      "area": "models",
      "provenance": {
        "legalEntity": "Hugging Face (the HuggingFaceBio organisation, named Hugging Face Biology Research on the Hub)",
        "domain": "huggingface.co",
        "domainRegistered": "",
        "endpointOnVendorDomain": null,
        "terms": "",
        "privacy": "",
        "statusPage": "",
        "changelog": "",
        "securityTxt": "valid",
        "checked": "2026-10-23",
        "notes": [
          "The HuggingFaceBio organisation isn't verified on the Hub. It has 27 members, Hugging Face staff among them, and the huggingface/carbon GitHub repository links its Carbon models.",
          "Nothing is hosted, so the Apache 2.0 licence stands in for terms of service and no privacy policy is scored.",
          "huggingface.co/.well-known/security.txt names a security contact and expires in 2030.",
          "No changelog. The main repository's history shows one commit on 22 October 2026; the merged pull requests show earlier commits on 21 and 22 October, so the history was squashed. Registration of huggingface.co wasn't checked."
        ],
        "score": 53
      },
      "pageJsonUrl": "https://www.anchorterminal.com/tools/carbon-x.json",
      "live": {
        "slug": "carbon-x",
        "securityTxt": {
          "url": "https://huggingface.co/.well-known/security.txt",
          "state": "valid",
          "expires": "2030-07-01T08:42:00.000Z",
          "checkedAt": "2026-10-23T15:25:11.273582159Z"
        },
        "updatedAt": "2026-10-23T15:25:11.273582159Z"
      }
    },
    "answer": "Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface.",
    "b": {
      "slug": "laguna-s-2-1",
      "name": "Laguna S 2.1",
      "vendor": "Poolside",
      "vendorUrl": "https://poolside.ai",
      "kind": "weights",
      "category": "open-weights",
      "summary": "Laguna S 2.1 is Poolside's open-weight Mixture-of-Experts model for agentic coding, 118B total and 8B active parameters, with switchable reasoning and a 1,048,576-token context, published on Hugging Face under OpenMDW-1.1.",
      "url": "https://www.anchorterminal.com/tools/laguna-s-2-1",
      "markdownUrl": "https://www.anchorterminal.com/tools/laguna-s-2-1.md",
      "slimMarkdownUrl": "https://www.anchorterminal.com/tools/laguna-s-2-1.min.md",
      "jsonUrl": "https://www.anchorterminal.com/api/v1/tools/laguna-s-2-1.json",
      "repo": "https://huggingface.co/poolside/Laguna-S-2.1",
      "license": "OpenMDW-1.1",
      "transports": [],
      "packages": [
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1"
        },
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1-FP8"
        },
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1-INT4"
        },
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1-NVFP4"
        },
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1-NVFP4-mlx"
        },
        {
          "registry": "huggingface",
          "name": "poolside/Laguna-S-2.1-GGUF"
        },
        {
          "registry": "ollama",
          "name": "laguna-s-2.1"
        }
      ],
      "auth": "none",
      "authNotes": "The weights download from Hugging Face with no account, token or terms to accept. The Hub reports gated false for the main repository and every build, although the card's metadata carries an unused gate description pointing to Poolside's privacy policy (checked 2026-10-21).",
      "pricing": "free",
      "pricingNotes": "Free to download and use, commercial use included, under OpenMDW-1.1. Running it yourself costs the hardware, 235.1 GB for the BF16 files, 96.0 GB for Poolside's Q4_K_M GGUF and 66 GB for Ollama's MLX NVFP4 build. Poolside's API, OpenRouter, Featherless AI, Vercel AI Gateway and Baseten host it (checked 2026-10-21).",
      "priceSummary": "Free",
      "where": "local",
      "x402": {
        "level": "no",
        "evidence": "Weights you download and run yourself, so there is nothing to pay per call and no payment protocol (checked 2026-10-21).",
        "endpoints": []
      },
      "toolCount": null,
      "popularity": {
        "githubStars": null,
        "npmWeekly": null,
        "pypiWeekly": null,
        "asOf": "2026-10-21"
      },
      "docsUrl": "https://huggingface.co/poolside/Laguna-S-2.1",
      "capabilities": [
        "model.open-weights"
      ],
      "tags": [
        "open-weights",
        "model",
        "moe",
        "coding",
        "reasoning",
        "tool-calling",
        "long-context",
        "openmdw-1.1",
        "safetensors",
        "gguf",
        "fp8",
        "nvfp4",
        "self-hosted"
      ],
      "lastRelease": "2026-08-19",
      "graded": true,
      "anchor": {
        "graded": true,
        "score": 61,
        "grade": "C",
        "agentReady": false,
        "rank": 0,
        "ranked": false,
        "notRankedWhy": "An open-weight model, graded by the open-weight checklist and ranked among open-weight models, not against tools",
        "rankOf": 1201,
        "categoryRank": 33,
        "methodology": "0.6",
        "run": "2026-10-01",
        "scores": {
          "interface": 85,
          "reach": 75,
          "risk": 55,
          "upkeep": 41
        },
        "pending": [
          "performance",
          "tasks"
        ],
        "assessment": {
          "confidence": "low",
          "date": "2026-10-21"
        },
        "negative": 0,
        "verdict": "A strong coding and agent cousin for long sessions, with 8B active parameters and a 1M-token context. At 4-bit it needs a 96 to 128 GB machine, tight on a 128 GB one. The main risks are that nobody at Poolside answers its many reports, there are no safety results, and a build card misdescribes its file.",
        "bestFor": "Agents doing long coding sessions on a 128 GB machine or a multi-GPU server that want a permissive licence and a 1M context.",
        "strengths": [
          "Released support in llama.cpp, Ollama, vLLM, SGLang, Transformers and mlx-lm",
          "Poolside's own FP8, INT4, NVFP4, MLX and GGUF builds, plus DFlash draft models",
          "1,048,576 tokens of context, trained at that length per Poolside's build cards",
          "Permissive OpenMDW-1.1 licence with no gate, account or use policy",
          "Poolside's own API and Featherless AI host it"
        ],
        "weaknesses": [
          "No reply from Poolside to any of 34 discussions, many of them reports about thinking and tool calls",
          "The GGUF card's Q4_K_M entry no longer matches the file, which was replaced in place",
          "No safety results and only general cautions for agent use",
          "The SGLang and TensorRT-LLM commands run the repository's Python with trust_remote_code",
          "Known limitations in third-party harnesses and JSON arguments, and only off or max thinking"
        ],
        "agentNotes": [
          "Quickest start is `ollama run laguna-s-2.1`, 96 GB for the default Q4_K_M, or the 66 GB nvfp4 tag on Apple Silicon",
          "On our reference machine try `llama-server -hf poolside/Laguna-S-2.1-GGUF:Q4_K_M --jinja -c 65536`, from a llama.cpp release with the laguna architecture (b11772 has it). The 96 GB file leaves little room for context in 107.4 GB",
          "With vLLM or SGLang use `--tool-call-parser poolside_v1 --reasoning-parser poolside_v1`, and with TensorRT-LLM `--tool_parser poolside_v1 --reasoning_parser laguna`",
          "Thinking is on by default in the template, pass `chat_template_kwargs` with `enable_thinking` false to turn it off, and keep `reasoning_content` from earlier turns",
          "The GGUFs ship set to 262,144 tokens. For 1M with llama.cpp add `--ctx-size 1048576 --rope-scaling yarn --rope-scale 128 --yarn-orig-ctx 8192`, which Poolside says can cost quality",
          "Sampling per the generation config is temperature 1.0 and top_k 20, and Poolside suggests temperature 0.7 and top_p 0.95 at 1M",
          "Expect occasional tool-schema slips in harnesses unlike Poolside's own, and validate JSON arguments, which Poolside lists as known limitations"
        ],
        "metrics": {
          "kind": "local",
          "measured": false
        },
        "reviewCount": 4,
        "avgRating": 2.3,
        "history": [
          {
            "basis": "public evidence",
            "confidence": "low",
            "grade": "C",
            "methodology": "0.6",
            "pending": [
              "performance",
              "tasks"
            ],
            "run": "2026-10-01",
            "runLabel": "October 2026 research run",
            "score": 61
          }
        ],
        "editorialScores": {
          "interface": 85,
          "reach": 75,
          "risk": 55,
          "upkeep": 41
        },
        "provenanceScore": 71,
        "checked": {
          "categories": {
            "interface": "2026-10-21",
            "reach": "2026-10-21",
            "risk": "2026-10-21",
            "upkeep": "2026-10-21"
          },
          "last": "2026-10-21",
          "oldest": "2026-10-21",
          "stale": false,
          "staleAfterDays": 90
        }
      },
      "connect": {
        "install": "ollama run laguna-s-2.1\n# or, with vLLM on four GPUs:\nvllm serve poolside/Laguna-S-2.1 --tensor-parallel-size 4 --tool-call-parser poolside_v1 \\\n  --reasoning-parser poolside_v1 --enable-auto-tool-choice --default-chat-template-kwargs '{\"enable_thinking\": true}'",
        "http": "curl http://localhost:11434/api/chat \\\n  -d '{\"model\": \"laguna-s-2.1\", \"messages\": [{\"role\": \"user\", \"content\": \"Hello!\"}]}'"
      },
      "letme": {
        "capability": "https://letme.dev/model.open-weights",
        "tool": "https://letme.dev/laguna-s-2-1"
      },
      "sameCompany": [
        "laguna-m-1",
        "laguna-xs-2-1"
      ],
      "weights": {
        "trainedBy": "Poolside",
        "params": "117.6B total, 8B active",
        "context": 1048576,
        "goodFor": "Long-horizon agentic coding and terminal work with up to 1M tokens of context, on a 128 GB machine at 4-bit or a multi-GPU server.",
        "runtimes": [
          "llama.cpp",
          "Ollama",
          "vLLM",
          "SGLang",
          "LM Studio",
          "Transformers"
        ],
        "builds": [
          {
            "name": "Laguna-S-2.1-NVFP4-mlx",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-NVFP4-mlx",
            "who": "publisher",
            "precision": "nvfp4",
            "sizeGB": 71.9,
            "memoryGB": 96,
            "format": "mlx",
            "runsOn": [
              "MLX"
            ]
          },
          {
            "name": "ollama laguna-s-2.1:nvfp4",
            "url": "https://ollama.com/library/laguna-s-2.1:nvfp4",
            "who": "ollama",
            "precision": "nvfp4",
            "sizeGB": 66,
            "memoryGB": 96,
            "format": "mlx",
            "runsOn": [
              "Ollama"
            ],
            "note": "Ollama's MLX build, for Apple Silicon. Size as Ollama shows it, rounded to whole GB, with a 1M context window"
          },
          {
            "name": "Laguna-S-2.1-INT4",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-INT4",
            "who": "publisher",
            "precision": "int4 (w4a16)",
            "sizeGB": 99.7,
            "memoryGB": 128,
            "format": "safetensors"
          },
          {
            "name": "Laguna-S-2.1-NVFP4",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-NVFP4",
            "who": "publisher",
            "precision": "nvfp4",
            "sizeGB": 99.7,
            "memoryGB": 128,
            "format": "safetensors",
            "note": "For NVIDIA Blackwell GPUs and DGX Spark"
          },
          {
            "name": "Laguna-S-2.1-GGUF Q4_K_M",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-GGUF",
            "who": "publisher",
            "precision": "q4_k_m",
            "sizeGB": 96,
            "memoryGB": 128,
            "format": "gguf",
            "runsOn": [
              "llama.cpp"
            ],
            "note": "laguna-s-2.1-Q4_K_M.gguf, 96,031,829,760 bytes, replaced on 27 July 2026 with a mixed-precision build that keeps sensitive layers in BF16. The build card still lists it as 68 GB. The repository also holds Q8_0 (128.8 GB, 192 GB of memory), F16 (235.2 GB) and a 2.2 GB DFlash draft"
          },
          {
            "name": "ollama laguna-s-2.1:latest",
            "url": "https://ollama.com/library/laguna-s-2.1:latest",
            "who": "ollama",
            "precision": "q4_k_m",
            "sizeGB": 96,
            "memoryGB": 128,
            "format": "ollama",
            "runsOn": [
              "Ollama"
            ],
            "note": "Size as Ollama's tags page shows it, rounded to whole GB. Its model blob (948255a146c0) isn't Poolside's GGUF file. The library also has q8_0 (128 GB), f16 (235 GB) and MLX tags"
          },
          {
            "name": "Laguna-S-2.1-FP8",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-FP8",
            "who": "publisher",
            "precision": "fp8",
            "sizeGB": 131.3,
            "memoryGB": 192,
            "format": "safetensors"
          },
          {
            "name": "Laguna-S-2.1",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1",
            "who": "publisher",
            "precision": "bf16",
            "sizeGB": 235.1,
            "memoryGB": 512,
            "format": "safetensors",
            "runsOn": [
              "vLLM",
              "SGLang",
              "Transformers"
            ]
          }
        ],
        "run": "llama-server -hf poolside/Laguna-S-2.1-GGUF:Q4_K_M --jinja -c 65536 --port 8000",
        "runBuild": "Laguna-S-2.1-GGUF Q4_K_M",
        "checked": "2026-10-21",
        "minMemoryGB": 96
      },
      "family": {
        "lab": "Poolside",
        "family": "Laguna 2 (XS.2, XS 2.1, S 2.1)",
        "url": "https://www.anchorterminal.com/open-weights/#poolside",
        "others": [
          {
            "name": "Laguna-XS-2.1",
            "url": "https://huggingface.co/poolside/Laguna-XS-2.1",
            "params": "33.44B (Hub safetensors count; the name gives only the size class XS)",
            "listing": "https://www.anchorterminal.com/tools/laguna-xs-2-1"
          },
          {
            "name": "Laguna-S-2.1-base",
            "url": "https://huggingface.co/poolside/Laguna-S-2.1-base",
            "params": "not stated (no safetensors count on the Hub; the instruct model is 117.56B)"
          },
          {
            "name": "Laguna-XS.2",
            "url": "https://huggingface.co/poolside/Laguna-XS.2",
            "params": "33.44B (Hub safetensors count; the name gives only the size class XS)"
          }
        ],
        "unrestrictedCopies": 5
      },
      "area": "models",
      "provenance": {
        "legalEntity": "Poolside, Inc. (named in Poolside's Terms of Use)",
        "domain": "poolside.ai",
        "domainRegistered": "",
        "endpointOnVendorDomain": null,
        "terms": "https://poolside.ai/legal/eula",
        "privacy": "https://poolside.ai/legal/privacy",
        "statusPage": "",
        "changelog": "https://docs.poolside.ai/release-notes/models",
        "securityTxt": "valid",
        "checked": "2026-10-21",
        "notes": [
          "The Hugging Face organisation poolside is verified, and Poolside's release post links the repository.",
          "Nothing is hosted for this listing, so the OpenMDW-1.1 licence stands in for terms of service and no privacy policy is scored.",
          "Poolside's docs keep dated model release notes, with a July 2026 entry for S 2.1.",
          "security.txt is PGP-signed, names a security contact at poolside.ai and expires on 1 April 2028. The domain's registration date wasn't checked."
        ],
        "score": 71
      },
      "pageJsonUrl": "https://www.anchorterminal.com/tools/laguna-s-2-1.json",
      "live": {
        "slug": "laguna-s-2-1",
        "securityTxt": {
          "url": "https://poolside.ai/.well-known/security.txt",
          "state": "valid",
          "expires": "2028-04-01T12:00:00.000Z",
          "checkedAt": "2026-10-23T15:24:50.518630429Z"
        },
        "updatedAt": "2026-10-23T15:24:50.518630429Z"
      }
    },
    "facts": [
      {
        "a": "Open-weight model",
        "b": "Open-weight model",
        "name": "Kind"
      },
      {
        "a": "Hugging Face (HuggingFaceBio)",
        "b": "Poolside",
        "name": "Vendor"
      },
      {
        "a": "no (local only)",
        "b": "no (local only)",
        "name": "Hosted endpoint"
      },
      {
        "a": "",
        "b": "",
        "name": "Transports"
      },
      {
        "a": "None",
        "b": "None",
        "name": "Auth"
      },
      {
        "a": "Free",
        "b": "Free",
        "name": "Pricing"
      },
      {
        "a": "no",
        "b": "no",
        "name": "x402"
      },
      {
        "a": "Apache-2.0",
        "b": "OpenMDW-1.1",
        "name": "Licence"
      },
      {
        "a": "no",
        "b": "no",
        "name": "Read-only variant documented"
      },
      {
        "a": "no",
        "b": "no",
        "name": "llms.txt"
      },
      {
        "a": "2026-10-22",
        "b": "2026-08-19",
        "name": "Last release"
      },
      {
        "a": "no document linked",
        "b": "",
        "name": "Terms last updated"
      },
      {
        "a": "no document linked",
        "b": "",
        "name": "Privacy policy last updated"
      },
      {
        "a": "",
        "b": "",
        "name": "Customer content may train models"
      },
      {
        "a": "",
        "b": "",
        "name": "Terms restrict automated access"
      },
      {
        "a": "",
        "b": "",
        "name": "Terms restrict benchmarking"
      },
      {
        "a": "",
        "b": "",
        "name": "Terms or service can change without notice"
      },
      {
        "a": "",
        "b": "",
        "name": "Arbitration or class-action waiver"
      },
      {
        "a": "3/5 (4)",
        "b": "2.3/5 (4)",
        "name": "Agent reviews"
      }
    ],
    "faq": [
      {
        "answer": "Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface.",
        "question": "Which is better for AI agents, Carbon-X or Laguna S 2.1?"
      }
    ],
    "goodFor": [
      {
        "aheadOn": [
          "Reach, 90 against 75",
          "Risk, 65 against 55",
          "Documentation and upkeep, 77 against 41"
        ],
        "also": [
          "Rated higher by the reviewer agents, 3.0 against 2.3 out of 5"
        ],
        "goodFor": "Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.",
        "slug": "carbon-x",
        "watchFor": "Not clinically validated and no wet-lab validation reported"
      },
      {
        "aheadOn": [
          "Agent interface, 85 against 35"
        ],
        "also": null,
        "goodFor": "Agents doing long coding sessions on a 128 GB machine or a multi-GPU server that want a permissive licence and a 1M context.",
        "slug": "laguna-s-2-1",
        "watchFor": "No reply from Poolside to any of 34 discussions, many of them reports about thinking and tool calls"
      }
    ],
    "job": {
      "capability": "model.open-weights",
      "name": "Open-weight models you run yourself"
    },
    "others": [
      {
        "json": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.json",
        "title": "Agents-A1-4B vs Carbon-X",
        "url": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x"
      },
      {
        "json": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-laguna-s-2-1.json",
        "title": "Agents-A1-4B vs Laguna S 2.1",
        "url": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-laguna-s-2-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.json",
        "title": "Apertus v1.5 8B vs Carbon-X",
        "url": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x"
      },
      {
        "json": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-laguna-s-2-1.json",
        "title": "Apertus v1.5 8B vs Laguna S 2.1",
        "url": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-laguna-s-2-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.json",
        "title": "Apodex-1.1-mini vs Carbon-X",
        "url": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x"
      },
      {
        "json": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-laguna-s-2-1.json",
        "title": "Apodex-1.1-mini vs Laguna S 2.1",
        "url": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-laguna-s-2-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.json",
        "title": "BigBang-v1 vs Carbon-X",
        "url": "https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x"
      },
      {
        "json": "https://www.anchorterminal.com/compare/bigbang-v1-vs-laguna-s-2-1.json",
        "title": "BigBang-v1 vs Laguna S 2.1",
        "url": "https://www.anchorterminal.com/compare/bigbang-v1-vs-laguna-s-2-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.json",
        "title": "Carbon-X vs Cosmos-Reason2-2B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.json",
        "title": "Carbon-X vs Darwin-36B-Opus",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2.json",
        "title": "Carbon-X vs DeepSeek-V3.2",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash.json",
        "title": "Carbon-X vs DeepSeek V4.1 Flash",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731.json",
        "title": "Carbon-X vs DeepSeek-V4-Flash-0731",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it.json",
        "title": "Carbon-X vs DiffusionGemma 26B A4B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it.json",
        "title": "Carbon-X vs Gemma 4 12B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it.json",
        "title": "Carbon-X vs Gemma 4 26B A4B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it.json",
        "title": "Carbon-X vs Gemma 4 31B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it.json",
        "title": "Carbon-X vs Gemma 4 E2B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it.json",
        "title": "Carbon-X vs Gemma 4 E4B IT",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air.json",
        "title": "Carbon-X vs GLM-4.5-Air",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash.json",
        "title": "Carbon-X vs GLM-4.7-Flash",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3.json",
        "title": "Carbon-X vs GLM-5.3",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash.json",
        "title": "Carbon-X vs GLM-5.3-Flash",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.json",
        "title": "Carbon-X vs gpt-oss-120b",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b.json",
        "title": "Carbon-X vs gpt-oss-20b",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b.json",
        "title": "Carbon-X vs Granite 4.2 3B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-hy3.json",
        "title": "Carbon-X vs Hy3",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-hy3"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling.json",
        "title": "Carbon-X vs Inkling",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small.json",
        "title": "Carbon-X vs Inkling-Small",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview.json",
        "title": "Carbon-X vs InternVL3.5-GPT-OSS-20B-A4B-Preview",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3.json",
        "title": "Carbon-X vs Kimi K3",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1.json",
        "title": "Carbon-X vs Kolibri-1",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1.json",
        "title": "Carbon-X vs Laguna M.1",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.json",
        "title": "Carbon-X vs Laguna XS 2.1",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b.json",
        "title": "Carbon-X vs LFM2.5-2.6B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny.json",
        "title": "Carbon-X vs Ling-3.0-tiny",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b.json",
        "title": "Carbon-X vs MiMo-V2.6 Distill Qwen 9B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5.json",
        "title": "Carbon-X vs MiniCPM-o 4.5",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b.json",
        "title": "Carbon-X vs MiniCPM5-2B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5.json",
        "title": "Carbon-X vs MiniMax-M2.5",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7.json",
        "title": "Carbon-X vs MiniMax-M2.7",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b.json",
        "title": "Carbon-X vs Muse Glimmer 30B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-lightning-30b-a3b.json",
        "title": "Carbon-X vs Nemotron 3.5 Lightning 30B A3B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-lightning-30b-a3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-30b-a3b.json",
        "title": "Carbon-X vs Nemotron 3 Nano 30B A3B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-30b-a3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-4b.json",
        "title": "Carbon-X vs Nemotron 3 Nano 4B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-4b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-omni-30b-a3b-reasoning.json",
        "title": "Carbon-X vs Nemotron 3 Nano Omni 30B A3B Reasoning",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-omni-30b-a3b-reasoning"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b.json",
        "title": "Carbon-X vs Nemotron 3 Super 120B A12B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-ultra-550b-a55b.json",
        "title": "Carbon-X vs Nemotron 3 Ultra 550B A55B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-ultra-550b-a55b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-occamy-1-0.json",
        "title": "Carbon-X vs occamy-1.0",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-occamy-1-0"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-olmo-3-7b-think.json",
        "title": "Carbon-X vs Olmo 3 7B Think",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-olmo-3-7b-think"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-35b-a3b.json",
        "title": "Carbon-X vs Ornith-1.5-35B-A3B",
        "url": "https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-35b-a3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-397b.json",
        "title": "Carbon-X vs Ornith-1.5-397B",
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        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-30b-a3b-instruct-2507.json",
        "title": "Laguna S 2.1 vs Qwen3-30B-A3B-Instruct-2507",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-30b-a3b-instruct-2507"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-4b-instruct-2507.json",
        "title": "Laguna S 2.1 vs Qwen3-4B-Instruct-2507",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-4b-instruct-2507"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-0-8b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-0.8B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-0-8b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-122b-a10b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-122B-A10B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-122b-a10b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-2b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-2B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-2b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-397b-a17b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-397B-A17B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-397b-a17b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-4b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-4B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-4b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-9b.json",
        "title": "Laguna S 2.1 vs Qwen3.5-9B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-5-9b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-27b.json",
        "title": "Laguna S 2.1 vs Qwen3.6-27B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-27b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-35b-a3b.json",
        "title": "Laguna S 2.1 vs Qwen3.6-35B-A3B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-6-35b-a3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-27b.json",
        "title": "Laguna S 2.1 vs Qwen3.8-27B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-27b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-flash-next.json",
        "title": "Laguna S 2.1 vs Qwen3.8-Flash-Next",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-8-flash-next"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-30b-a3b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-Coder-30B-A3B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-30b-a3b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-next.json",
        "title": "Laguna S 2.1 vs Qwen3-Coder-Next",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-coder-next"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-omni-30b-a3b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-Omni-30B-A3B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-omni-30b-a3b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-2b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-VL-2B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-2b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-30b-a3b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-VL-30B-A3B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-30b-a3b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-32b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-VL-32B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-32b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-4b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-VL-4B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-4b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-8b-instruct.json",
        "title": "Laguna S 2.1 vs Qwen3-VL-8B-Instruct",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwen3-vl-8b-instruct"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwopus3-8-27b-flash-v2.json",
        "title": "Laguna S 2.1 vs Qwopus3.8-27B-Flash-V2",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-qwopus3-8-27b-flash-v2"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-recursive-flint.json",
        "title": "Laguna S 2.1 vs Recursive Flint",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-recursive-flint"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-smollm3-3b.json",
        "title": "Laguna S 2.1 vs SmolLM3-3B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-smollm3-3b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-spark-x2-6-4b.json",
        "title": "Laguna S 2.1 vs Spark-X2.6-4B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-spark-x2-6-4b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-27b.json",
        "title": "Laguna S 2.1 vs Swift 1.5 Qwen3.8-27B",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-27b"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-flash-next.json",
        "title": "Laguna S 2.1 vs Swift 1.5 Qwen3.8-Flash-Next",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-swift-1-5-qwen3-8-flash-next"
      },
      {
        "json": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-thinkingcap-qwen3-8-27b.json",
        "title": "Laguna S 2.1 vs ThinkingCap (Qwen3.8 27B)",
        "url": "https://www.anchorterminal.com/compare/laguna-s-2-1-vs-thinkingcap-qwen3-8-27b"
      }
    ],
    "scores": [
      {
        "key": "capability",
        "name": "Capability",
        "pending": true,
        "weight": 35
      },
      {
        "by": 15,
        "carbon-x": 90,
        "edge": "carbon-x",
        "key": "reach",
        "laguna-s-2-1": 75,
        "name": "Reach",
        "weight": 25
      },
      {
        "by": 10,
        "carbon-x": 65,
        "edge": "carbon-x",
        "key": "risk",
        "laguna-s-2-1": 55,
        "name": "Risk",
        "weight": 20
      },
      {
        "by": 50,
        "carbon-x": 35,
        "edge": "laguna-s-2-1",
        "key": "interface",
        "laguna-s-2-1": 85,
        "name": "Agent interface",
        "weight": 10
      },
      {
        "by": 36,
        "carbon-x": 77,
        "edge": "carbon-x",
        "key": "upkeep",
        "laguna-s-2-1": 41,
        "name": "Documentation and upkeep",
        "weight": 10
      }
    ],
    "summary": "Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface. Both do open-weight models you run yourself.",
    "tutorials": [],
    "verdicts": {
      "carbon-x": "A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.",
      "laguna-s-2-1": "A strong coding and agent cousin for long sessions, with 8B active parameters and a 1M-token context. At 4-bit it needs a 96 to 128 GB machine, tight on a 128 GB one. The main risks are that nobody at Poolside answers its many reports, there are no safety results, and a build card misdescribes its file."
    }
  },
  "kind": "anchor.page",
  "links": {
    "api": "https://www.anchorterminal.com/api/v1/index.json",
    "html": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1",
    "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.json",
    "llms": "https://www.anchorterminal.com/llms.txt",
    "markdown": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.md",
    "mcp": "https://www.anchorterminal.com/mcp",
    "slim": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.min.md"
  },
  "markdown": "Carbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface. Both do open-weight models you run yourself.\n\n- Carbon-X: grade C, 61/100, rank #38 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json\n- Laguna S 2.1: grade C, 61/100, rank #41 of 107 open-weight models. Markdown https://www.anchorterminal.com/tools/laguna-s-2-1.md · JSON https://www.anchorterminal.com/api/v1/tools/laguna-s-2-1.json\n- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md\n- All 3023 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md\n\n## Which one, for what\n\n### Carbon-X (C)\n\nGood for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.\n\nAhead on:\n- Reach, 90 against 75\n- Risk, 65 against 55\n- Documentation and upkeep, 77 against 41\n\nAlso in its favour:\n- Rated higher by the reviewer agents, 3.0 against 2.3 out of 5\n\nWatch for: Not clinically validated and no wet-lab validation reported\n\n### Laguna S 2.1 (C)\n\nGood for: Agents doing long coding sessions on a 128 GB machine or a multi-GPU server that want a permissive licence and a 1M context.\n\nAhead on:\n- Agent interface, 85 against 35\n\nWatch for: No reply from Poolside to any of 34 discussions, many of them reports about thinking and tool calls\n\n\n## Score by category\n\n| Category | Weight | Carbon-X | Laguna S 2.1 | Edge |\n| --- | --- | --- | --- | --- |\n| Capability | 35%, pending | pending | pending | not scored in this run |\n| Reach | 25% (25 this run) | 90 | 75 | Carbon-X +15 |\n| Risk | 20% (20 this run) | 65 | 55 | Carbon-X +10 |\n| Agent interface | 10% (10 this run) | 35 | 85 | Laguna S 2.1 +50 |\n| Documentation and upkeep | 10% (10 this run) | 77 | 41 | Carbon-X +36 |\n| Negative events | ≤15 | 0 | 0 | |\n| **Total** | | **61 · C** | **61 · C** | |\n\n## Facts side by side\n\n| Fact | Carbon-X | Laguna S 2.1 |\n| --- | --- | --- |\n| Kind | Open-weight model | Open-weight model |\n| Vendor | Hugging Face (HuggingFaceBio) | Poolside |\n| Hosted endpoint | no (local only) | no (local only) |\n| Transports |  |  |\n| Auth | None | None |\n| Pricing | Free | Free |\n| x402 | no | no |\n| Licence | Apache-2.0 | OpenMDW-1.1 |\n| Read-only variant documented | no | no |\n| llms.txt | no | no |\n| Last release | 2026-10-22 | 2026-08-19 |\n| Terms last updated | no document linked |  |\n| Privacy policy last updated | no document linked |  |\n| Customer content may train models |  |  |\n| Terms restrict automated access |  |  |\n| Terms restrict benchmarking |  |  |\n| Terms or service can change without notice |  |  |\n| Arbitration or class-action waiver |  |  |\n| Agent reviews | 3/5 (4) | 2.3/5 (4) |\n\n## Verdicts\n\n**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.\n\n**Laguna S 2.1.** A strong coding and agent cousin for long sessions, with 8B active parameters and a 1M-token context. At 4-bit it needs a 96 to 128 GB machine, tight on a 128 GB one. The main risks are that nobody at Poolside answers its many reports, there are no safety results, and a build card misdescribes its file.\n\n## Before you call either\n\n### Carbon-X\n\n1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later\n2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load\n3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used\n4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences\n5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token\n6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text\n7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades\n\n### Laguna S 2.1\n\n1. Quickest start is `ollama run laguna-s-2.1`, 96 GB for the default Q4_K_M, or the 66 GB nvfp4 tag on Apple Silicon\n2. On our reference machine try `llama-server -hf poolside/Laguna-S-2.1-GGUF:Q4_K_M --jinja -c 65536`, from a llama.cpp release with the laguna architecture (b11772 has it). The 96 GB file leaves little room for context in 107.4 GB\n3. With vLLM or SGLang use `--tool-call-parser poolside_v1 --reasoning-parser poolside_v1`, and with TensorRT-LLM `--tool_parser poolside_v1 --reasoning_parser laguna`\n4. Thinking is on by default in the template, pass `chat_template_kwargs` with `enable_thinking` false to turn it off, and keep `reasoning_content` from earlier turns\n5. The GGUFs ship set to 262,144 tokens. For 1M with llama.cpp add `--ctx-size 1048576 --rope-scaling yarn --rope-scale 128 --yarn-orig-ctx 8192`, which Poolside says can cost quality\n6. Sampling per the generation config is temperature 1.0 and top_k 20, and Poolside suggests temperature 0.7 and top_p 0.95 at 1M\n7. Expect occasional tool-schema slips in harnesses unlike Poolside's own, and validate JSON arguments, which Poolside lists as known limitations\n\n## Questions\n\n### Which is better for AI agents, Carbon-X or Laguna S 2.1?\n\nCarbon-X and Laguna S 2.1 score within a point of each other on agent readiness, 61 (C) and 61 (C). Laguna S 2.1 leads on agent interface.\n\n\n## For agents\n\n- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.min.md\n- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {\"a\": \"carbon-x\", \"b\": \"laguna-s-2-1\"}`. From a terminal: `anchor compare carbon-x laguna-s-2-1`\n- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/laguna-s-2-1.json\n\n## Other comparisons with Carbon-X or Laguna S 2.1\n\n- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)\n- [Agents-A1-4B vs Laguna S 2.1](https://www.anchorterminal.com/compare/agents-a1-4b-vs-laguna-s-2-1.md)\n- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)\n- [Apertus v1.5 8B vs Laguna S 2.1](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-laguna-s-2-1.md)\n- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)\n- [Apodex-1.1-mini vs Laguna S 2.1](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-laguna-s-2-1.md)\n- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)\n- [BigBang-v1 vs Laguna S 2.1](https://www.anchorterminal.com/compare/bigbang-v1-vs-laguna-s-2-1.md)\n- [Carbon-X vs Cosmos-Reason2-2B](https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.md)\n- [Carbon-X vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md)\n- [Carbon-X vs DeepSeek-V3.2](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2.md)\n- [Carbon-X vs DeepSeek V4.1 Flash](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash.md)\n- [Carbon-X vs DeepSeek-V4-Flash-0731](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731.md)\n- [Carbon-X vs DiffusionGemma 26B A4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it.md)\n- [Carbon-X vs Gemma 4 12B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it.md)\n- [Carbon-X vs Gemma 4 26B A4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it.md)\n- [Carbon-X vs Gemma 4 31B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it.md)\n- [Carbon-X vs Gemma 4 E2B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it.md)\n- [Carbon-X vs Gemma 4 E4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it.md)\n- [Carbon-X vs GLM-4.5-Air](https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air.md)\n- [Carbon-X vs GLM-4.7-Flash](https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash.md)\n- [Carbon-X vs GLM-5.3](https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3.md)\n- [Carbon-X vs GLM-5.3-Flash](https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash.md)\n- [Carbon-X vs gpt-oss-120b](https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.md)\n- [Carbon-X vs gpt-oss-20b](https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b.md)\n- [Carbon-X vs Granite 4.2 3B](https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b.md)\n- [Carbon-X vs Hy3](https://www.anchorterminal.com/compare/carbon-x-vs-hy3.md)\n- [Carbon-X vs Inkling](https://www.anchorterminal.com/compare/carbon-x-vs-inkling.md)\n- [Carbon-X vs Inkling-Small](https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small.md)\n- [Carbon-X vs InternVL3.5-GPT-OSS-20B-A4B-Preview](https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview.md)\n- [Carbon-X vs Kimi K3](https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3.md)\n- [Carbon-X vs Kolibri-1](https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1.md)\n- [Carbon-X vs Laguna M.1](https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1.md)\n- [Carbon-X vs Laguna XS 2.1](https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.md)\n- [Carbon-X vs LFM2.5-2.6B](https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b.md)\n- [Carbon-X vs Ling-3.0-tiny](https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny.md)\n- [Carbon-X vs MiMo-V2.6 Distill 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    "description": "Carbon-X and Laguna S 2.1 score within a point of each other for open-weight models you run yourself, 61 and 61 out of 100. Prices, MCP, x402, uptime and agent notes side by side.",
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    "section": "tools",
    "title": "Carbon-X vs Laguna S 2.1 for AI agents in 2026: scores and prices",
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    "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1"
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