Head to head · Agent frameworks · October 2026 research run
Agno vs guilds.run
Agno scores 72.8 (BB) on agent readiness against guilds.run's 56.5 (C), and leads in 5 of 7 scored categories. guilds.run leads on payments & pricing. Both do agent frameworks.
Best agent frameworks and SDKs · All 55 frameworks comparisons
Which one, for what
Agno BB
Best for Python teams that want agents, teams and workflows plus a self-hosted server with REST, MCP, approvals and scheduling in one package.
Ahead on
- Reliability, 83 against 53
- Schema & documentation, 90 against 58
- Agent ergonomics, 76 against 67
- Maintenance & community, 86 against 41
- Transparency & trust, 83 against 52
Also in its favour
- Agent-ready, a grade of BB or better
Watch for
Usage telemetry is on by default and sends session, run and agent identifiers unhashed. Prompts and outputs are not sent
Best for A person or small team that wants a standing, inspectable team of agents with schedules, shared tables and a web app, run on one machine, and is comfortable tracking main.
Ahead on
- Payments & pricing, 60 against 50
Also in its favour
- Free to start without a card
Watch for
No tagged release, version number, changelog or published image. Users install whatever is on main
Score by category
| Category | Weight this run | Agno | guilds.run | Edge |
|---|---|---|---|---|
| Reliability | 16%20 | 83 | 53 | Agno +30 |
| Performance | 10%pending | pending | pending | not scored in this run |
| Schema & documentation | 13%16.2 | 90 | 58 | Agno +32 |
| Agent ergonomics | 13%16.2 | 76 | 67 | Agno +9 |
| Security & auth | 14%17.5 | 64 | 68 | guilds.run +4 |
| Payments & pricing | 10%12.5 | 50 | 60 | guilds.run +10 |
| Task success | 10%pending | pending | pending | not scored in this run |
| Maintenance & community | 7%8.8 | 86 | 41 | Agno +45 |
| Transparency & trust | 7%8.8 | 83 | 52 | Agno +31 |
| Negative events | ≤15 | -3 | -2 | |
| Total | BB 72.8/100 | C 56.5/100 |
Facts side by side
| Fact | Agno | guilds.run |
|---|---|---|
| Kind | Agent framework | Agent framework |
| Vendor | Agno Inc. | Cigale AI |
| Hosted endpoint | no (local only) | no (local only) |
| Transports | ||
| Auth | API key | API key |
| Pricing | Free | Free |
| x402 | no | no |
| Licence | Apache-2.0 | AGPL-3.0-only |
| Read-only variant documented | no | no |
| llms.txt | yes | no |
| Last release | 2026-10-02 | none |
| Terms last updated | couldn't be read | no document linked |
| Privacy policy last updated | couldn't be read | no document linked |
| Customer content may train models | couldn't be read | |
| Terms restrict automated access | couldn't be read | |
| Terms restrict benchmarking | couldn't be read | |
| Terms or service can change without notice | couldn't be read | |
| Arbitration or class-action waiver | couldn't be read | |
| Popularity | 43k stars, 476k PyPI/wk | 57 stars |
Verdicts
Agno
An Apache 2.0 Python agent framework at 3.1.1 with an MCP client, tool confirmation and admin approvals, a durable job queue and 25 stable releases in 90 days. Usage telemetry is on by default with unhashed identifiers, and three high or critical advisories were published against it in the last 12 months, all fixed.
guilds.run
A self-hosted multi-agent system that records each run's prompt, tool calls and memory changes, with per-agent models and tools and no telemetry by default. Public since 9 October 2026, it has no tagged release or published package, its own security register lists 13 open issues, and the site's terms and privacy links return 404.
Before you call either
Agno
- Set AGNO_TELEMETRY=false before the first run, and pass telemetry=False to AgentOS and to each eval, which ignore the variable
- Configure JWT_VERIFICATION_KEY with AgentOS authorisation switched on, or OS_SECURITY_KEY, before exposing AgentOS. With neither set, REST and MCP routes take no credential
- Mark tools that write with requires_confirmation, and resume with continue_run once every requirement is resolved
- Set tool_call_limit on agents. The default is None
- Install extras for what you use, such as agno[mcp] for MCPTools and agno[os,mcp] for AgentOS with its MCP server
guilds.run
- Keep the box on loopback or behind an authenticating proxy with AUTH_MODE=trusted-header. The default mode does not authenticate
- Put agents that hold different secrets or GitHub tokens on different machines. Agents on one machine can read each other's homes and tokens
- Back up the .env file written by ./setup.sh. It holds the only copy of the key that encrypts stored credentials
- Set a spend limit at your model provider. guilds.run sets no spend cap, and max_tool_calls defaults to 50 per run
- Pin a commit of main when you deploy. There are no tagged releases or versioned images yet
Questions
Which is better for AI agents, Agno or guilds.run?
Agno scores 72.8 (BB) on agent readiness against guilds.run's 56.5 (C), and leads in 5 of 7 scored categories. guilds.run leads on payments & pricing.
Are Agno and guilds.run open source?
Yes. Agno is open source (Apache-2.0). guilds.run is open source (AGPL-3.0-only).
Other comparisons with Agno or guilds.run
- AgentOS vs Agno
- AgentOS vs guilds.run
- Agno vs Claude Agent SDK
- Agno vs CrewAI
- Agno vs Docker Agent
- Agno vs Agent Development Kit (ADK)
- Agno vs LangGraph
- Agno vs Microsoft Agent Framework
- Agno vs OpenAI Agents SDK
- Agno vs Pydantic AI
- Claude Agent SDK vs guilds.run
- CrewAI vs guilds.run
- Docker Agent vs guilds.run
- Agent Development Kit (ADK) vs guilds.run
- guilds.run vs LangGraph
- guilds.run vs Microsoft Agent Framework
- guilds.run vs OpenAI Agents SDK
- guilds.run vs Pydantic AI
Machine-readable
- This page as Markdown
/compare/agno-vs-guilds-run.md· slim.min.md· JSON.json(or sendAccept: text/markdown) - Each listing in full
/api/v1/tools/agno.json·/api/v1/tools/guilds-run.json - From a terminal
anchor compare agno guilds-run(the CLI) - Over MCP
compare_tools {"a": "agno", "b": "guilds-run"}at/mcp, no key