Head to head · Patient record retrieval · October 2026 research run

1upHealth vs Zus Health

Zus Health scores 56.6 (C) on agent readiness against 1upHealth's 46.8 (D), and leads in 4 of 7 scored categories. 1upHealth leads on security & auth, payments & pricing and transparency & trust. Both do patient record retrieval.

Best health record and wellness data APIs for AI agents · All 63 health comparisons

Which one, for what

1upHealth D

Best for Consumer and care apps that read a member's health plan claims and clinical data under the CMS rules, and payers meeting those rules.

Ahead on

  • Security & auth, 63 against 49
  • Payments & pricing, 20 against 5
  • Transparency & trust, 72 against 59

Watch for

No rate limits, 429 handling or error formats documented

Zus Health C

Best for US care organisations and digital health builders that want a shared, continuously refreshed patient profile in FHIR with EHR embedding.

Ahead on

  • Reliability, 66 against 52
  • Schema & documentation, 77 against 50
  • Agent ergonomics, 67 against 32
  • Maintenance & community, 64 against 37

Watch for

No public prices, and the sandbox is requested through a Google Form

Score by category

CategoryWeight this run1upHealthZus HealthEdge
Reliability16%205266Zus Health +14
Performance10%pendingpendingpendingnot scored in this run
Schema & documentation13%16.25077Zus Health +27
Agent ergonomics13%16.23267Zus Health +35
Security & auth14%17.563491upHealth +14
Payments & pricing10%12.52051upHealth +15
Task success10%pendingpendingpendingnot scored in this run
Maintenance & community7%8.83764Zus Health +27
Transparency & trust7%8.872591upHealth +13
Negative events≤1500
TotalD 46.8/100C 56.6/100

Facts side by side

Fact1upHealthZus Health
KindHTTP APIHTTP API
Vendor1upHealth, Inc.Zus Health, Inc.
Hosted endpointno (local only)no (local only)
TransportsHTTPHTTP
AuthOAuthOAuth
PricingPaidPaid
x402nono
LicenceProprietary service under 1upHealth's Terms of Service (effective 1 August 2024)Proprietary service under the Zus Builder Terms of Service (last updated 11 March 2025), the Developer Sandbox Terms and the Zus Business Associate Addendum
Read-only variant documentednono
llms.txtyesyes
Last releasenone2026-10-14
Terms last updatedno date given2025-03-11
Privacy policy last updated2026-06-252026-06-24
Customer content may train modelsnot found in the textnot found in the text
Terms restrict automated accessnot found in the textnot found in the text
Terms restrict benchmarkingyesnot found in the text
Terms or service can change without noticenot found in the textnot found in the text
Arbitration or class-action waivernot found in the textnot found in the text

Verdicts

1upHealth

Self-serve Dev Portal sandbox clients and a demo health plan let an app test the CMS Patient Access, Provider Access and Payer-to-Payer FHIR APIs, backed by HITRUST and SOC 2 Type 2. No rate limits, error formats or dated releases are documented, and the Patient Access OAuth step needs the member in a browser.

Zus Health

FHIR R4 over an aggregated patient profile drawn from CommonWell, Carequality, Surescripts, Quest and ADT networks, with published rate limits, a 99.5 per cent SLA and a dated changelog. Accounts and sandboxes are provisioned by Zus on request, with no public prices, no named security certification and no SDK.

Before you call either

1upHealth

  1. Hand the Patient Access sign-in to the member, who must authorise in the health plan's auth app
  2. Exchange the authorisation code within five minutes, and refresh before the 15-minute token expires
  3. Email payer-patient-access@1up.health with the client ID to get the app synced to the demo environment
  4. Expect only claims and coverage resources from some payers, and read /r4/metadata first

Zus Health

  1. Cache the access token for its hour. More than 200 token requests an hour per App Client returns 429
  2. Request Patient History at most once per patient per 24 hours, and poll the job status endpoint
  3. Use conditional create by identifier so a retried write doesn't duplicate a resource
  4. Send Zus-If-Match with the resource's ETag on PUT and PATCH
  5. Set _count up to 500 on searches, since the default page is 10

Questions

Which is better for AI agents, 1upHealth or Zus Health?

Zus Health scores 56.6 (C) on agent readiness against 1upHealth's 46.8 (D), and leads in 4 of 7 scored categories. 1upHealth leads on security & auth, payments & pricing and transparency & trust.

Do 1upHealth and Zus Health need an API key?

Both use an OAuth sign-in.

Can an agent call 1upHealth and Zus Health without installing anything?

No hosted endpoint is listed for 1upHealth. No hosted endpoint is listed for Zus Health.

Other comparisons with 1upHealth or Zus Health

Machine-readable

For companies

Do agents find, use and choose your tools?

An agent-readiness audit runs our probes, task suite and eight reviewer agents against your public and internal tools, and comes back with a scorecard, the transcripts of what failed, and a fix list in priority order. From $2,500, re-run included. We never take payment to move a rank. We do help companies earn one.