{ "data": { "a": { "slug": "carbon-x", "name": "Carbon-X", "vendor": "Hugging Face (HuggingFaceBio)", "vendorUrl": "https://huggingface.co/HuggingFaceBio", "kind": "weights", "category": "open-weights", "summary": "Carbon-X is Hugging Face's open-weight 14.8B language model for DNA, a fine-tune of Qwen3-14B that reads raw DNA in a chat and answers in English about variant effects and regulatory regions, with a 40,960-token context, under Apache 2.0.", "url": "https://www.anchorterminal.com/tools/carbon-x", "markdownUrl": "https://www.anchorterminal.com/tools/carbon-x.md", "slimMarkdownUrl": "https://www.anchorterminal.com/tools/carbon-x.min.md", "jsonUrl": "https://www.anchorterminal.com/api/v1/tools/carbon-x.json", "repo": "https://huggingface.co/HuggingFaceBio/Carbon-X", "license": "Apache-2.0", "transports": [], "packages": [ { "registry": "huggingface", "name": "HuggingFaceBio/Carbon-X" }, { "registry": "huggingface", "name": "HuggingFaceBio/Carbon-X-GGUF" } ], "auth": "none", "authNotes": "The weights download from Hugging Face with no account, token or terms to accept. The Hub reports gated false for HuggingFaceBio/Carbon-X and HuggingFaceBio/Carbon-X-GGUF (checked 2026-10-23). The Python tokenizer fetches Qwen/Qwen3-4B-Base's tokenizer at a pinned revision on first load, which is also ungated.", "pricing": "free", "pricingNotes": "Free to download and use, commercial use included, under Apache 2.0, and the base Qwen3-14B is Apache 2.0 too. Hugging Face sells no per-call access to it and no inference provider serves it. Running it costs the hardware, 29.6 GB for the BF16 safetensors and 9.6 GB for the publisher's smallest GGUF, Q4_K_M (checked 2026-10-23).", "priceSummary": "Free", "where": "local", "x402": { "level": "no", "evidence": "Weights you download and run yourself, so there is nothing to pay per call and no payment protocol (checked 2026-10-23).", "endpoints": [] }, "toolCount": null, "popularity": { "githubStars": null, "npmWeekly": null, "pypiWeekly": null, "asOf": "2026-10-23" }, "docsUrl": "https://huggingface.co/HuggingFaceBio/Carbon-X", "capabilities": [ "model.open-weights" ], "tags": [ "open-weights", "model", "dense", "dna", "genomics", "biology", "fine-tune", "apache-2.0", "safetensors", "gguf", "self-hosted" ], "lastRelease": "2026-10-22", "graded": true, "anchor": { "graded": true, "score": 61, "grade": "C", "agentReady": false, "rank": 0, "ranked": false, "notRankedWhy": "An open-weight model, graded by the open-weight checklist and ranked among open-weight models, not against tools", "rankOf": 1239, "categoryRank": 30, "methodology": "0.7", "run": "2026-10-01", "scores": { "interface": 35, "reach": 90, "risk": 65, "upkeep": 77 }, "pending": [ "performance", "tasks" ], "assessment": { "confidence": "low", "date": "2026-10-23" }, "negative": 0, "verdict": "A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.", "bestFor": "Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.", "strengths": [ "Hugging Face's own GGUFs at four precisions, the smallest about 12 GB with a fifth added", "Runs in released llama.cpp, vLLM, SGLang and Transformers", "Apache 2.0 on the model and its Qwen3-14B base, nothing gated", "A ready-made skill, an OpenAI-style tool example and an Inspect example for calling it from another agent", "Mid-training data listed by source with shares of 302B tokens" ], "weaknesses": [ "Not clinically validated and no wet-lab validation reported", "The Python tokenizer needs trust_remote_code, and llama.cpp before b11742 tokenizes DNA wrongly", "Not trained for tool calling, structured output or reasoning", "The card says llama.cpp is unsupported while the publisher's GGUF repository says it is", "No inference provider or hosted API, and no knowledge cut-off" ], "agentNotes": [ "Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later", "With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load", "Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used", "Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences", "Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token", "Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text", "Cap max_tokens for next-base questions, long DNA generation is slow and degrades" ], "metrics": { "kind": "local", "measured": false }, "reviewCount": 4, "avgRating": 3, "history": [ { "basis": "public evidence", "confidence": "low", "grade": "C", "methodology": "0.7", "pending": [ "performance", "tasks" ], "run": "2026-10-01", "runLabel": "October 2026 research run", "score": 61 } ], "editorialScores": { "interface": 35, "reach": 90, "risk": 65, "upkeep": 77 }, "provenanceScore": 61, "checked": { "categories": { "interface": "2026-10-23", "reach": "2026-10-23", "risk": "2026-10-23", "upkeep": "2026-10-23" }, "last": "2026-10-23", "oldest": "2026-10-23", "stale": false, "staleAfterDays": 90 } }, "connect": { "install": "# llama.cpp b11742 or later (older builds tokenize DNA wrongly):\nllama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja \\\n --chat-template-kwargs '{\"enable_thinking\": false}' \\\n --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0 --port 8080\n# or, with vLLM:\nvllm serve HuggingFaceBio/Carbon-X --trust-remote-code", "http": "curl http://localhost:8080/v1/chat/completions -H 'Content-Type: application/json' \\\n -d '{\"messages\": [{\"role\": \"user\", \"content\": \"Is this sequence more likely coding or non-coding? ATGGCGCTGTGGATGCGCCTCCTG\"}]}'" }, "letme": { "capability": "https://letme.dev/model.open-weights", "tool": "https://letme.dev/carbon-x" }, "sameCompany": [ "hugging-face-inference-endpoints", "smollm3-3b" ], "weights": { "trainedBy": "Hugging Face with Zhongguancun Academy and TIGEM / University of Naples Federico II", "builtOn": "Qwen/Qwen3-14B (vocabulary extension, mid-training, supervised fine-tune and GRPO; base Apache 2.0, declared in the card's metadata)", "params": "14.8B", "context": 40960, "goodFor": "A DNA specialist another agent calls, for variant-effect questions, regulatory regions and next-base prediction on raw DNA kept on local hardware.", "runtimes": [ "llama.cpp", "vLLM", "SGLang", "Transformers" ], "builds": [ { "name": "Carbon-X-GGUF Q4_K_M", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF", "who": "publisher", "precision": "q4_k_m", "sizeGB": 9.64, "memoryGB": 12, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "carbon-x-q4_k_m.gguf, 9,636,318,080 bytes. Embedding and output tensors stay at Q8_0. The publisher's own runs put it lowest of the builds on FrontierVEP (67.8) and NextBase (38.6)" }, { "name": "Carbon-X-GGUF Q6_K", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF", "who": "publisher", "precision": "q6_k", "sizeGB": 12.56, "memoryGB": 16, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "carbon-x-q6_k.gguf, 12,555,946,880 bytes" }, { "name": "Carbon-X-GGUF Q5_K_M", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF", "who": "publisher", "precision": "q5_k_m", "sizeGB": 11.05, "memoryGB": 16, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "carbon-x-q5_k_m.gguf, 11,051,895,680 bytes" }, { "name": "Carbon-X-GGUF Q8_0", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF", "who": "publisher", "precision": "q8_0", "sizeGB": 15.76, "memoryGB": 24, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "carbon-x-q8_0.gguf, 15,755,742,080 bytes, the build the publisher recommends" }, { "name": "Carbon-X", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X", "who": "publisher", "precision": "bf16", "sizeGB": 29.64, "memoryGB": 48, "format": "safetensors", "runsOn": [ "vLLM", "Transformers" ], "note": "Needs trust_remote_code for the custom HybridDNATokenizer, and Transformers v5 or later. The card says it fits one 80 GB GPU" }, { "name": "Carbon-X-GGUF BF16", "url": "https://huggingface.co/HuggingFaceBio/Carbon-X-GGUF", "who": "publisher", "precision": "bf16", "sizeGB": 29.65, "memoryGB": 48, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "carbon-x-bf16.gguf, 29,651,012,480 bytes. llama.cpp b11742 or later" } ], "run": "llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0 --port 8080", "runBuild": "Carbon-X-GGUF Q8_0", "checked": "2026-10-23", "minMemoryGB": 12 }, "family": { "lab": "Hugging Face (Carbon)", "family": "Carbon", "url": "https://www.anchorterminal.com/open-weights/#huggingface-bio", "others": [ { "name": "Carbon-A-1.2B", "url": "https://huggingface.co/HuggingFaceBio/Carbon-A-1.2B", "params": "1.2B" }, { "name": "Carbon-8B", "url": "https://huggingface.co/HuggingFaceBio/Carbon-8B", "params": "8.3B" }, { "name": "Carbon-3B", "url": "https://huggingface.co/HuggingFaceBio/Carbon-3B", "params": "3.5B" }, { "name": "Carbon-500M", "url": "https://huggingface.co/HuggingFaceBio/Carbon-500M", "params": "0.5B" } ] }, "area": "models", "provenance": { "legalEntity": "Hugging Face (the HuggingFaceBio organisation, named Hugging Face Biology Research on the Hub)", "domain": "huggingface.co", "domainRegistered": "", "endpointOnVendorDomain": null, "terms": "", "privacy": "", "statusPage": "", "changelog": "", "securityTxt": "valid", "checked": "2026-10-23", "notes": [ "The HuggingFaceBio organisation isn't verified on the Hub. It has 27 members, Hugging Face staff among them, and the huggingface/carbon GitHub repository links its Carbon models.", "Nothing is hosted, so the Apache 2.0 licence stands in for terms of service and no privacy policy is scored.", "huggingface.co/.well-known/security.txt names a security contact and expires in 2030.", "No changelog. The main repository's history shows one commit on 22 October 2026; the merged pull requests show earlier commits on 21 and 22 October, so the history was squashed. Registration of huggingface.co wasn't checked." ], "score": 61 }, "pageJsonUrl": "https://www.anchorterminal.com/tools/carbon-x.json", "live": { "slug": "carbon-x", "securityTxt": { "url": "https://huggingface.co/.well-known/security.txt", "state": "valid", "expires": "2030-07-01T08:42:00.000Z", "checkedAt": "2026-10-30T15:37:44.33625603Z" }, "domain": { "domain": "huggingface.co", "checkedAt": "2026-10-25T13:59:29.030902536Z" }, "updatedAt": "2026-10-30T15:37:44.33625603Z" } }, "answer": "Carbon-X scores 61 (C) on agent readiness against Mistral Large 4's 54.6 (C), and leads in 2 of 4 scored categories. Mistral Large 4 leads on risk and agent interface.", "b": { "slug": "mistral-large-4", "name": "Mistral Large 4", "vendor": "Mistral AI", "vendorUrl": "https://mistral.ai", "kind": "weights", "category": "open-weights", "summary": "Mistral Large 4 (\"Le Chonk\") is Mistral AI's open-weight mixture-of-experts model of about 1T parameters with 52B active, taking text and images, with three reasoning efforts and a 1M-token context, published in FP8 and NVFP4.", "url": "https://www.anchorterminal.com/tools/mistral-large-4", "markdownUrl": "https://www.anchorterminal.com/tools/mistral-large-4.md", "slimMarkdownUrl": "https://www.anchorterminal.com/tools/mistral-large-4.min.md", "jsonUrl": "https://www.anchorterminal.com/api/v1/tools/mistral-large-4.json", "repo": "https://huggingface.co/mistralai/Mistral-Large-4-1T-A52B", "license": "Mistral Ecosystem Open-Weight License (modified MIT)", "transports": [], "packages": [ { "registry": "huggingface", "name": "mistralai/Mistral-Large-4-1T-A52B" }, { "registry": "huggingface", "name": "mistralai/Mistral-Large-4-1T-A52B-NVFP4" } ], "auth": "none", "authNotes": "The weights download from Hugging Face with no account, token or terms to accept. Both repositories report gated false (checked 2026-10-30).", "pricing": "free", "pricingNotes": "Free to download. The Mistral Ecosystem Open-Weight License allows commercial use, except that a licensee or affiliate that operates a Model-as-a-Service business needs a separate commercial licence from Mistral before any commercial use; internal use and use through Mistral's own products are exempt. Mistral's API serves it as mistral-large-4 at $0.70 input, $0.07 cached input and $2.10 output per million tokens (checked 2026-10-30).", "priceSummary": "Free", "where": "local", "x402": { "level": "no", "evidence": "Weights you download and run yourself, so there is nothing to pay per call and no payment protocol (checked 2026-10-30).", "endpoints": [] }, "toolCount": null, "popularity": { "githubStars": null, "npmWeekly": null, "pypiWeekly": null, "asOf": "2026-10-30" }, "docsUrl": "https://huggingface.co/mistralai/Mistral-Large-4-1T-A52B", "capabilities": [ "model.open-weights" ], "tags": [ "open-weights", "model", "moe", "multimodal", "frontier", "reasoning", "tool-calling", "long-context", "multilingual", "safetensors", "fp8", "nvfp4", "self-hosted" ], "lastRelease": "2026-10-29", "graded": true, "anchor": { "graded": true, "score": 54.6, "grade": "C", "agentReady": false, "rank": 0, "ranked": false, "notRankedWhy": "An open-weight model, graded by the open-weight checklist and ranked among open-weight models, not against tools", "rankOf": 1239, "categoryRank": 72, "methodology": "0.7", "run": "2026-10-01", "scores": { "capability": 32, "interface": 95, "reach": 50, "risk": 75, "upkeep": 64 }, "pending": [ "performance", "tasks" ], "assessment": { "confidence": "medium", "date": "2026-10-30" }, "negative": 0, "verdict": "A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.", "bestFor": "Operators with an 8-GPU Blackwell or H200 node who want a frontier-sized open model for coding agents and defensive security, with a hosted twin on Mistral's API.", "strengths": [ "Safetensors only, loaded by Transformers' own code with a Jinja template, in Mistral's verified organisation with a hash on every file", "Tool calling documented end to end with a named parser, several calls a turn and strict JSON Schema output", "Reasoning effort budgeted per request, low, medium or high, with the reasoning returned apart from the answer", "FP8 and NVFP4 builds from Mistral, and Mistral's own API serves the same model for agents without the hardware", "First among open-weight models on Cognition's FrontierCode 2.0 leaderboard, run in Mistral's own harness" ], "weaknesses": [ "The smallest 4-bit build needs about 732 GB, so nothing fits a single workstation or a 128 GB machine", "No vLLM or SGLang release supports it yet, only Docker images tagged mistral-large-4", "A Model-as-a-Service business needs a separate commercial licence from Mistral before any commercial use", "Safety results are Mistral's own with no settings to rerun them, and no limitations, training data sources or knowledge cut-off are published", "The 1M context comes from YaRN scaling with no stated trained length, and thinking can't be turned off" ], "agentNotes": [ "Serve the NVFP4 build on Blackwell with `vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice`; released vLLM doesn't load it", "On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe", "Pass `reasoning_effort` low, medium or high (default high); any other value makes the template raise an error, and there is no off switch", "Read the reasoning from `message.reasoning`; `max_completion_tokens` counts reasoning tokens too", "Use temperature 1.0 and top_p 0.95 at every effort, per the card", "Ask for JSON with `response_format` type json_schema and strict true; the template passes the schema to the model", "The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message", "Add `--speculative-config '{\"method\": \"dspark\", \"num_speculative_tokens\": 3}'` to use the embedded draft head", "If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence" ], "metrics": { "kind": "local", "measured": false }, "reviewCount": 0, "avgRating": 0, "history": [ { "basis": "public evidence", "confidence": "medium", "grade": "C", "methodology": "0.7", "pending": [ "performance", "tasks" ], "run": "2026-10-01", "runLabel": "October 2026 research run", "score": 54.6 } ], "editorialScores": { "capability": 32, "interface": 95, "reach": 50, "risk": 75, "upkeep": 64 }, "provenanceScore": 84, "checked": { "categories": { "capability": "2026-10-30", "interface": "2026-10-30", "reach": "2026-10-30", "risk": "2026-10-30", "upkeep": "2026-10-30" }, "last": "2026-10-30", "oldest": "2026-10-30", "stale": false, "staleAfterDays": 90 } }, "connect": { "install": "# NVFP4 on 4 or 8 Blackwell GPUs, with the card's vLLM image (no vLLM release supports it yet):\ndocker run --runtime nvidia --gpus all -v ~/.cache/huggingface:/root/.cache/huggingface -p 8000:8000 --ipc=host \\\n vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 \\\n --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral \\\n --reasoning-parser mistral --enable-auto-tool-choice --gpu-memory-utilization 0.85", "http": "curl http://localhost:8000/v1/chat/completions \\\n -H \"Content-Type: application/json\" \\\n -d '{\"model\": \"mistralai/Mistral-Large-4-1T-A52B-NVFP4\", \"reasoning_effort\": \"medium\", \"temperature\": 1.0, \"top_p\": 0.95,\n \"messages\": [{\"role\": \"user\", \"content\": \"Hello!\"}]}'" }, "letme": { "capability": "https://letme.dev/model.open-weights", "tool": "https://letme.dev/mistral-large-4" }, "sameCompany": [ "mistral-embeddings", "mistral-moderation", "mistral-voxtral-transcribe", "voxtral-mini-4b-realtime-2602", "mistral-ocr", "mistral-vibe-cli" ], "sameModel": [ "mistral-api" ], "weights": { "trainedBy": "Mistral AI", "params": "~1T total (1.05T per Mistral's docs), 52B active", "context": 1048576, "goodFor": "Frontier-sized multimodal model for coding agents, defensive security work and long documents, with tool calling, strict JSON Schema output and three reasoning efforts, for operators with a multi-GPU server.", "runtimes": [ "llama.cpp", "Transformers" ], "builds": [ { "name": "Mistral-Large-4-1T-A52B-NVFP4", "url": "https://huggingface.co/mistralai/Mistral-Large-4-1T-A52B-NVFP4", "who": "publisher", "precision": "nvfp4", "sizeGB": 610, "memoryGB": 1024, "format": "safetensors", "runsOn": [ "vLLM (mistral-large-4 image)", "SGLang (mistral-large-4 image)" ], "note": "NVFP4 experts with FP8 linears, for Blackwell GPUs; Mistral-format params.json only, no config.json, so not for Transformers" }, { "name": "ggml-org Mistral-Large-4-1T-A52B-GGUF Q4_K_M", "url": "https://huggingface.co/ggml-org/Mistral-Large-4-1T-A52B-GGUF", "who": "ggml-org (llama.cpp)", "precision": "q4_k_m", "sizeGB": 634.8, "memoryGB": 1024, "format": "gguf", "runsOn": [ "llama.cpp" ], "note": "llama.cpp's own organisation, linked from Mistral's card. Also BF16, Q8_0, Q2_K (380.7 GB) and IQ2_XXS (297.7 GB), plus an NVFP4 GGUF of 619.4 GB in a second repository; the 2-bit files are below the 4-bit line and aren't counted. Vision projector 3.4 GB extra" }, { "name": "Mistral-Large-4-1T-A52B", "url": "https://huggingface.co/mistralai/Mistral-Large-4-1T-A52B", "who": "publisher", "precision": "fp8", "sizeGB": 1060.6, "memoryGB": 2048, "format": "safetensors", "runsOn": [ "Transformers", "vLLM (mistral-large-4 image)", "SGLang (mistral-large-4 image)" ], "note": "Block-scaled FP8 (128 by 128), the release precision; vision tower, projector, output head and some attention projections kept in BF16. Includes the DSpark draft head" } ], "run": "docker run --runtime nvidia --gpus all -v ~/.cache/huggingface:/root/.cache/huggingface -p 8000:8000 --ipc=host vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice --gpu-memory-utilization 0.85", "runBuild": "Mistral-Large-4-1T-A52B-NVFP4", "checked": "2026-10-30", "minMemoryGB": 1024 }, "family": { "lab": "Mistral AI", "family": "Mistral Large 4", "url": "https://www.anchorterminal.com/open-weights/#mistral", "olderCount": 49 }, "area": "models", "provenance": { "legalEntity": "Mistral AI (RCS Paris 952 418 325)", "domain": "mistral.ai", "domainRegistered": "2019-05-15", "endpointOnVendorDomain": null, "terms": "", "privacy": "", "statusPage": "", "changelog": "https://huggingface.co/mistralai/Mistral-Large-4-1T-A52B/commits/main", "securityTxt": "valid", "checked": "2026-10-30", "notes": [ "The files sit in Mistral's verified mistralai organisation, which the card, Mistral's announcement and its docs page for the model link to. Legal entity and domain registration are carried from the mistral-api listing.", "Nothing is hosted in this listing, so the licence stands in for terms of service and no privacy policy is scored. The hosted model is mistral-api.", "The changelog is the repositories' commit history, an initial release on 29 October 2026 and two card edits the same day, plus a merged evaluation figure on the NVFP4 card.", "mistral.ai/.well-known/security.txt answered on 30 October 2026 with a security contact, an expiry of 5 May 2027 and a HackerOne submission policy." ], "score": 84 }, "pageJsonUrl": "https://www.anchorterminal.com/tools/mistral-large-4.json" }, "facts": [ { "a": "Open-weight model", "b": "Open-weight model", "name": "Kind" }, { "a": "Hugging Face (HuggingFaceBio)", "b": "Mistral AI", "name": "Vendor" }, { "a": "no (local only)", "b": "no (local only)", "name": "Hosted endpoint" }, { "a": "", "b": "", "name": "Transports" }, { "a": "None", "b": "None", "name": "Auth" }, { "a": "Free", "b": "Free", "name": "Pricing" }, { "a": "no", "b": "no", "name": "x402" }, { "a": "Apache-2.0", "b": "Mistral Ecosystem Open-Weight License (modified MIT)", "name": "Licence" }, { "a": "no", "b": "no", "name": "Read-only variant documented" }, { "a": "no", "b": "no", "name": "llms.txt" }, { "a": "2026-10-22", "b": "2026-10-29", "name": "Last release" }, { "a": "no document linked", "b": "no document linked", "name": "Terms last updated" }, { "a": "no document linked", "b": "no document linked", "name": "Privacy policy last updated" }, { "a": "", "b": "", "name": "Customer content may train models" }, { "a": "", "b": "", "name": "Terms restrict automated access" }, { "a": "", "b": "", "name": "Terms restrict benchmarking" }, { "a": "", "b": "", "name": "Terms or service can change without notice" }, { "a": "", "b": "", "name": "Arbitration or class-action waiver" }, { "a": "3/5 (4)", "b": "none", "name": "Agent reviews" } ], "faq": [ { "answer": "Carbon-X scores 61 (C) on agent readiness against Mistral Large 4's 54.6 (C), and leads in 2 of 4 scored categories. Mistral Large 4 leads on risk and agent interface.", "question": "Which is better for AI agents, Carbon-X or Mistral Large 4?" } ], "goodFor": [ { "aheadOn": [ "Reach, 90 against 50", "Documentation and upkeep, 77 against 64" ], "also": null, "goodFor": "Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.", "slug": "carbon-x", "watchFor": "Not clinically validated and no wet-lab validation reported" }, { "aheadOn": [ "Risk, 75 against 65", "Agent interface, 95 against 35" ], "also": null, "goodFor": "Operators with an 8-GPU Blackwell or H200 node who want a frontier-sized open model for coding agents and defensive security, with a hosted twin on Mistral's API.", "slug": "mistral-large-4", "watchFor": "The smallest 4-bit build needs about 732 GB, so nothing fits a single workstation or a 128 GB machine" } ], "job": { "capability": "model.open-weights", "name": "Open-weight models you run yourself" }, "others": [ { "json": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.json", "title": "Agents-A1-4B vs Carbon-X", "url": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x" }, { "json": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-mistral-large-4.json", "title": "Agents-A1-4B vs Mistral Large 4", "url": "https://www.anchorterminal.com/compare/agents-a1-4b-vs-mistral-large-4" }, { "json": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.json", "title": "Apertus v1.5 8B vs Carbon-X", "url": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x" }, { "json": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-mistral-large-4.json", "title": "Apertus v1.5 8B vs Mistral Large 4", "url": "https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-mistral-large-4" }, { "json": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.json", "title": "Apodex-1.1-mini vs Carbon-X", "url": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x" }, { "json": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-mistral-large-4.json", "title": "Apodex-1.1-mini vs Mistral Large 4", "url": "https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-mistral-large-4" }, { "json": "https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.json", "title": "BigBang-v1 vs Carbon-X", "url": "https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x" }, { "json": "https://www.anchorterminal.com/compare/bigbang-v1-vs-mistral-large-4.json", "title": "BigBang-v1 vs Mistral Large 4", "url": "https://www.anchorterminal.com/compare/bigbang-v1-vs-mistral-large-4" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.json", "title": "Carbon-X vs Cosmos-Reason2-2B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.json", "title": "Carbon-X vs Darwin-36B-Opus", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2.json", "title": "Carbon-X vs DeepSeek-V3.2", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash.json", "title": "Carbon-X vs DeepSeek V4.1 Flash", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731.json", "title": "Carbon-X vs DeepSeek-V4-Flash-0731", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it.json", "title": "Carbon-X vs DiffusionGemma 26B A4B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it.json", "title": "Carbon-X vs Gemma 4 12B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it.json", "title": "Carbon-X vs Gemma 4 26B A4B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it.json", "title": "Carbon-X vs Gemma 4 31B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it.json", "title": "Carbon-X vs Gemma 4 E2B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it.json", "title": "Carbon-X vs Gemma 4 E4B IT", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air.json", "title": "Carbon-X vs GLM-4.5-Air", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash.json", "title": "Carbon-X vs GLM-4.7-Flash", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3.json", "title": "Carbon-X vs GLM-5.3", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash.json", "title": "Carbon-X vs GLM-5.3-Flash", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.json", "title": "Carbon-X vs gpt-oss-120b", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b.json", "title": "Carbon-X vs gpt-oss-20b", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b.json", "title": "Carbon-X vs Granite 4.2 3B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-hy3.json", "title": "Carbon-X vs Hy3", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-hy3" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling.json", "title": "Carbon-X vs Inkling", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small.json", "title": "Carbon-X vs Inkling-Small", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview.json", "title": "Carbon-X vs InternVL3.5-GPT-OSS-20B-A4B-Preview", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3.json", "title": "Carbon-X vs Kimi K3", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1.json", "title": "Carbon-X vs Kolibri-1", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-kronos.json", "title": "Carbon-X vs Kronos", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-kronos" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1.json", "title": "Carbon-X vs Laguna M.1", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.json", "title": "Carbon-X vs Laguna S 2.1", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.json", "title": "Carbon-X vs Laguna XS 2.1", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-lbs-27b.json", "title": "Carbon-X vs LBS-27B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-lbs-27b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b.json", "title": "Carbon-X vs LFM2.5-2.6B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny.json", "title": "Carbon-X vs Ling-3.0-tiny", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b.json", "title": "Carbon-X vs MiMo-V2.6 Distill Qwen 9B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5.json", "title": "Carbon-X vs MiniCPM-o 4.5", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b.json", "title": "Carbon-X vs MiniCPM5-2B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5.json", "title": "Carbon-X vs MiniMax-M2.5", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7.json", "title": "Carbon-X vs MiniMax-M2.7", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m3-1-flash.json", "title": "Carbon-X vs MiniMax-M3.1-Flash", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m3-1-flash" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b.json", "title": "Carbon-X vs Muse Glimmer 30B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nanbeige-4-3-33b.json", "title": "Carbon-X vs Nanbeige4.3-33B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nanbeige-4-3-33b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-bolt-e4b-4gb.json", "title": "Carbon-X vs NVIDIA Nemotron 3.5 Bolt E4B 4GB", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-bolt-e4b-4gb" }, { "json": 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"https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b.json", "title": "Carbon-X vs Nemotron 3 Super 120B A12B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-ultra-550b-a55b.json", "title": "Carbon-X vs Nemotron 3 Ultra 550B A55B", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-ultra-550b-a55b" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-occamy-1-0.json", "title": "Carbon-X vs occamy-1.0", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-occamy-1-0" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-olmo-3-7b-think.json", "title": "Carbon-X vs Olmo 3 7B Think", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-olmo-3-7b-think" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-ornith-1-5-35b-a3b.json", "title": "Carbon-X vs Ornith-1.5-35B-A3B", "url": 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"https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-30b-a3b-instruct.json", "title": "Carbon-X vs Qwen3-Coder-30B-A3B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-30b-a3b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-next.json", "title": "Carbon-X vs Qwen3-Coder-Next", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-coder-next" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-omni-30b-a3b-instruct.json", "title": "Carbon-X vs Qwen3-Omni-30B-A3B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-omni-30b-a3b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-2b-instruct.json", "title": "Carbon-X vs Qwen3-VL-2B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-2b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-30b-a3b-instruct.json", "title": "Carbon-X vs Qwen3-VL-30B-A3B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-30b-a3b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-32b-instruct.json", "title": "Carbon-X vs Qwen3-VL-32B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-32b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-4b-instruct.json", "title": "Carbon-X vs Qwen3-VL-4B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-4b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-8b-instruct.json", "title": "Carbon-X vs Qwen3-VL-8B-Instruct", "url": "https://www.anchorterminal.com/compare/carbon-x-vs-qwen3-vl-8b-instruct" }, { "json": "https://www.anchorterminal.com/compare/carbon-x-vs-qwopus3-8-27b-flash-v2.json", "title": "Carbon-X vs Qwopus3.8-27B-Flash-V2", "url": 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"https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-omni-30b-a3b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-2b-instruct.json", "title": "Mistral Large 4 vs Qwen3-VL-2B-Instruct", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-2b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-30b-a3b-instruct.json", "title": "Mistral Large 4 vs Qwen3-VL-30B-A3B-Instruct", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-30b-a3b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-32b-instruct.json", "title": "Mistral Large 4 vs Qwen3-VL-32B-Instruct", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-32b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-4b-instruct.json", "title": "Mistral Large 4 vs Qwen3-VL-4B-Instruct", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-4b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-8b-instruct.json", "title": "Mistral Large 4 vs Qwen3-VL-8B-Instruct", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwen3-vl-8b-instruct" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwopus3-8-27b-flash-v2.json", "title": "Mistral Large 4 vs Qwopus3.8-27B-Flash-V2", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-qwopus3-8-27b-flash-v2" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-recursive-flint.json", "title": "Mistral Large 4 vs Recursive Flint", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-recursive-flint" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-smollm3-3b.json", "title": "Mistral Large 4 vs SmolLM3-3B", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-smollm3-3b" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-spark-x2-6-4b.json", "title": "Mistral Large 4 vs Spark-X2.6-4B", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-spark-x2-6-4b" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-swift-1-5-qwen3-8-27b.json", "title": "Mistral Large 4 vs Swift 1.5 Qwen3.8-27B", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-swift-1-5-qwen3-8-27b" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-swift-1-5-qwen3-8-flash-next.json", "title": "Mistral Large 4 vs Swift 1.5 Qwen3.8-Flash-Next", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-swift-1-5-qwen3-8-flash-next" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-thinkingcap-qwen3-8-27b.json", "title": "Mistral Large 4 vs ThinkingCap (Qwen3.8 27B)", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-thinkingcap-qwen3-8-27b" }, { "json": "https://www.anchorterminal.com/compare/mistral-large-4-vs-unlimited-ocr-2.json", "title": "Mistral Large 4 vs Baidu Unlimited-OCR-2", "url": "https://www.anchorterminal.com/compare/mistral-large-4-vs-unlimited-ocr-2" } ], "scores": [ { "key": "capability", "name": "Capability", "pending": true, "weight": 35 }, { "by": 40, "carbon-x": 90, "edge": "carbon-x", "key": "reach", "mistral-large-4": 50, "name": "Reach", "weight": 25 }, { "by": 10, "carbon-x": 65, "edge": "mistral-large-4", "key": "risk", "mistral-large-4": 75, "name": "Risk", "weight": 20 }, { "by": 60, "carbon-x": 35, "edge": "mistral-large-4", "key": "interface", "mistral-large-4": 95, "name": "Agent interface", "weight": 10 }, { "by": 13, "carbon-x": 77, "edge": "carbon-x", "key": "upkeep", "mistral-large-4": 64, "name": "Documentation and upkeep", "weight": 10 } ], "summary": "Carbon-X scores 61 (C) on agent readiness against Mistral Large 4's 54.6 (C), and leads in 2 of 4 scored categories. Mistral Large 4 leads on risk and agent interface. Both do open-weight models you run yourself.", "tutorials": [], "verdicts": { "carbon-x": "A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.", "mistral-large-4": "A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal." } }, "kind": "anchor.page", "links": { "api": "https://www.anchorterminal.com/api/v1/index.json", "html": "https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4", "json": "https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4.json", "llms": "https://www.anchorterminal.com/llms.txt", "markdown": "https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4.md", "mcp": "https://www.anchorterminal.com/mcp", "slim": "https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4.min.md" }, "markdown": "Carbon-X scores 61 (C) on agent readiness against Mistral Large 4's 54.6 (C), and leads in 2 of 4 scored categories. Mistral Large 4 leads on risk and agent interface. Both do open-weight models you run yourself.\n\n- Carbon-X: grade C, 61/100, rank #39 of 117 open-weight models. Markdown https://www.anchorterminal.com/tools/carbon-x.md · JSON https://www.anchorterminal.com/api/v1/tools/carbon-x.json\n- Mistral Large 4: grade C, 54.6/100, rank #92 of 117 open-weight models. Markdown https://www.anchorterminal.com/tools/mistral-large-4.md · JSON https://www.anchorterminal.com/api/v1/tools/mistral-large-4.json\n- Best open-weight models you download and run yourself for AI agents: https://www.anchorterminal.com/best/open-weights/index.md\n- All 3588 open weights comparisons: https://www.anchorterminal.com/compare/open-weights/index.md\n\n## Which one, for what\n\n### Carbon-X (C)\n\nGood for: Agents that need a second opinion on DNA variants and regulatory regions on a 16 to 24 GB machine, without sending sequences to a hosted model.\n\nAhead on:\n- Reach, 90 against 50\n- Documentation and upkeep, 77 against 64\n\nWatch for: Not clinically validated and no wet-lab validation reported\n\n### Mistral Large 4 (C)\n\nGood for: Operators with an 8-GPU Blackwell or H200 node who want a frontier-sized open model for coding agents and defensive security, with a hosted twin on Mistral's API.\n\nAhead on:\n- Risk, 75 against 65\n- Agent interface, 95 against 35\n\nWatch for: The smallest 4-bit build needs about 732 GB, so nothing fits a single workstation or a 128 GB machine\n\n\n## Score by category\n\n| Category | Weight | Carbon-X | Mistral Large 4 | Edge |\n| --- | --- | --- | --- | --- |\n| Capability | 35%, pending | pending | pending | not scored in this run |\n| Reach | 25% (25 this run) | 90 | 50 | Carbon-X +40 |\n| Risk | 20% (20 this run) | 65 | 75 | Mistral Large 4 +10 |\n| Agent interface | 10% (10 this run) | 35 | 95 | Mistral Large 4 +60 |\n| Documentation and upkeep | 10% (10 this run) | 77 | 64 | Carbon-X +13 |\n| Negative events | ≤15 | 0 | 0 | |\n| **Total** | | **61 · C** | **54.6 · C** | |\n\n## Facts side by side\n\n| Fact | Carbon-X | Mistral Large 4 |\n| --- | --- | --- |\n| Kind | Open-weight model | Open-weight model |\n| Vendor | Hugging Face (HuggingFaceBio) | Mistral AI |\n| Hosted endpoint | no (local only) | no (local only) |\n| Transports | | |\n| Auth | None | None |\n| Pricing | Free | Free |\n| x402 | no | no |\n| Licence | Apache-2.0 | Mistral Ecosystem Open-Weight License (modified MIT) |\n| Read-only variant documented | no | no |\n| llms.txt | no | no |\n| Last release | 2026-10-22 | 2026-10-29 |\n| Terms last updated | no document linked | no document linked |\n| Privacy policy last updated | no document linked | no document linked |\n| Customer content may train models | | |\n| Terms restrict automated access | | |\n| Terms restrict benchmarking | | |\n| Terms or service can change without notice | | |\n| Arbitration or class-action waiver | | |\n| Agent reviews | 3/5 (4) | none |\n\n## Verdicts\n\n**Carbon-X.** A DNA specialist cousin that another agent calls for variant-effect and sequence questions, with DNA kept on the machine. Hugging Face's Q4_K_M GGUF needs about 12 GB and Q8_0 about 19 GB, on llama.cpp b11742 or later. It isn't clinically validated, it isn't trained for tool calls or reasoning, and the card contradicts its own GGUF repository on llama.cpp support.\n\n**Mistral Large 4.** A frontier-sized open cousin for coding agents and defensive security, with strict JSON Schema output, parallel tool calls and three reasoning efforts. It needs a multi-GPU server, about 732 GB for the smallest 4-bit build, and vLLM and SGLang run it only from special images. The main risk is a licence that bars Model-as-a-Service businesses without a separate deal.\n\n## Before you call either\n\n### Carbon-X\n\n1. Quickest start is `llama-server -hf HuggingFaceBio/Carbon-X-GGUF:Q8_0 -ngl 99 -c 40960 --jinja --chat-template-kwargs '{\"enable_thinking\": false}' --temp 0.6 --top-p 0.95 --top-k 20 --min-p 0`, on llama.cpp b11742 or later\n2. With vLLM or Transformers pass trust_remote_code, and expect the tokenizer to fetch Qwen/Qwen3-4B-Base at a pinned revision on first load\n3. Keep enable_thinking false and the card's sampling (temperature 0.6, top_p 0.95, top_k 20), the settings every reported result used\n4. Keep DNA in files and pass sequences by name, compute positions and base changes in code and send them as context, the card says the model miscounts long sequences\n5. Only A, C, G and T form 6-mers, so filter N and other IUPAC codes first or they become a single oov token\n6. Strip the dna tags from answers if you need bare sequence, llama.cpp keeps them in the text\n7. Cap max_tokens for next-base questions, long DNA generation is slow and degrades\n\n### Mistral Large 4\n\n1. Serve the NVFP4 build on Blackwell with `vllm/vllm-openai:mistral-large-4 --model mistralai/Mistral-Large-4-1T-A52B-NVFP4 --tensor-parallel-size 8 --kv-cache-dtype fp8_ds_mla --tool-call-parser mistral --reasoning-parser mistral --enable-auto-tool-choice`; released vLLM doesn't load it\n2. On H200 use the FP8 build with tensor parallelism of 16 or 8 by 2 pipelines, per vLLM's recipe\n3. Pass `reasoning_effort` low, medium or high (default high); any other value makes the template raise an error, and there is no off switch\n4. Read the reasoning from `message.reasoning`; `max_completion_tokens` counts reasoning tokens too\n5. Use temperature 1.0 and top_p 0.95 at every effort, per the card\n6. Ask for JSON with `response_format` type json_schema and strict true; the template passes the schema to the model\n7. The template rejects a tool message straight after a user message and a conversation that doesn't start with a user or system message\n8. Add `--speculative-config '{\"method\": \"dspark\", \"num_speculative_tokens\": 3}'` to use the embedded draft head\n9. If you'll offer it to others as a hosted model, read the licence first; Model-as-a-Service use needs Mistral's commercial licence\n\n## Questions\n\n### Which is better for AI agents, Carbon-X or Mistral Large 4?\n\nCarbon-X scores 61 (C) on agent readiness against Mistral Large 4's 54.6 (C), and leads in 2 of 4 scored categories. Mistral Large 4 leads on risk and agent interface.\n\n\n## For agents\n\n- This comparison as JSON: https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4.json, and with the fewest tokens: https://www.anchorterminal.com/compare/carbon-x-vs-mistral-large-4.min.md\n- Over MCP at https://www.anchorterminal.com/mcp (no key): `compare_tools {\"a\": \"carbon-x\", \"b\": \"mistral-large-4\"}`. From a terminal: `anchor compare carbon-x mistral-large-4`\n- Each listing in full: https://www.anchorterminal.com/api/v1/tools/carbon-x.json and https://www.anchorterminal.com/api/v1/tools/mistral-large-4.json\n\n## Other comparisons with Carbon-X or Mistral Large 4\n\n- [Agents-A1-4B vs Carbon-X](https://www.anchorterminal.com/compare/agents-a1-4b-vs-carbon-x.md)\n- [Agents-A1-4B vs Mistral Large 4](https://www.anchorterminal.com/compare/agents-a1-4b-vs-mistral-large-4.md)\n- [Apertus v1.5 8B vs Carbon-X](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-carbon-x.md)\n- [Apertus v1.5 8B vs Mistral Large 4](https://www.anchorterminal.com/compare/apertus-v1-5-8b-vs-mistral-large-4.md)\n- [Apodex-1.1-mini vs Carbon-X](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-carbon-x.md)\n- [Apodex-1.1-mini vs Mistral Large 4](https://www.anchorterminal.com/compare/apodex-1-1-mini-vs-mistral-large-4.md)\n- [BigBang-v1 vs Carbon-X](https://www.anchorterminal.com/compare/bigbang-v1-vs-carbon-x.md)\n- [BigBang-v1 vs Mistral Large 4](https://www.anchorterminal.com/compare/bigbang-v1-vs-mistral-large-4.md)\n- [Carbon-X vs Cosmos-Reason2-2B](https://www.anchorterminal.com/compare/carbon-x-vs-cosmos-reason2-2b.md)\n- [Carbon-X vs Darwin-36B-Opus](https://www.anchorterminal.com/compare/carbon-x-vs-darwin-36b-opus.md)\n- [Carbon-X vs DeepSeek-V3.2](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v3-2.md)\n- [Carbon-X vs DeepSeek V4.1 Flash](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-1-flash.md)\n- [Carbon-X vs DeepSeek-V4-Flash-0731](https://www.anchorterminal.com/compare/carbon-x-vs-deepseek-v4-flash-0731.md)\n- [Carbon-X vs DiffusionGemma 26B A4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-diffusiongemma-26b-a4b-it.md)\n- [Carbon-X vs Gemma 4 12B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-12b-it.md)\n- [Carbon-X vs Gemma 4 26B A4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-26b-a4b-it.md)\n- [Carbon-X vs Gemma 4 31B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-31b-it.md)\n- [Carbon-X vs Gemma 4 E2B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e2b-it.md)\n- [Carbon-X vs Gemma 4 E4B IT](https://www.anchorterminal.com/compare/carbon-x-vs-gemma-4-e4b-it.md)\n- [Carbon-X vs GLM-4.5-Air](https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-5-air.md)\n- [Carbon-X vs GLM-4.7-Flash](https://www.anchorterminal.com/compare/carbon-x-vs-glm-4-7-flash.md)\n- [Carbon-X vs GLM-5.3](https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3.md)\n- [Carbon-X vs GLM-5.3-Flash](https://www.anchorterminal.com/compare/carbon-x-vs-glm-5-3-flash.md)\n- [Carbon-X vs gpt-oss-120b](https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-120b.md)\n- [Carbon-X vs gpt-oss-20b](https://www.anchorterminal.com/compare/carbon-x-vs-gpt-oss-20b.md)\n- [Carbon-X vs Granite 4.2 3B](https://www.anchorterminal.com/compare/carbon-x-vs-granite-4-2-3b.md)\n- [Carbon-X vs Hy3](https://www.anchorterminal.com/compare/carbon-x-vs-hy3.md)\n- [Carbon-X vs Inkling](https://www.anchorterminal.com/compare/carbon-x-vs-inkling.md)\n- [Carbon-X vs Inkling-Small](https://www.anchorterminal.com/compare/carbon-x-vs-inkling-small.md)\n- [Carbon-X vs InternVL3.5-GPT-OSS-20B-A4B-Preview](https://www.anchorterminal.com/compare/carbon-x-vs-internvl3-5-gpt-oss-20b-a4b-preview.md)\n- [Carbon-X vs Kimi K3](https://www.anchorterminal.com/compare/carbon-x-vs-kimi-k3.md)\n- [Carbon-X vs Kolibri-1](https://www.anchorterminal.com/compare/carbon-x-vs-kolibri-1.md)\n- [Carbon-X vs Kronos](https://www.anchorterminal.com/compare/carbon-x-vs-kronos.md)\n- [Carbon-X vs Laguna M.1](https://www.anchorterminal.com/compare/carbon-x-vs-laguna-m-1.md)\n- [Carbon-X vs Laguna S 2.1](https://www.anchorterminal.com/compare/carbon-x-vs-laguna-s-2-1.md)\n- [Carbon-X vs Laguna XS 2.1](https://www.anchorterminal.com/compare/carbon-x-vs-laguna-xs-2-1.md)\n- [Carbon-X vs LBS-27B](https://www.anchorterminal.com/compare/carbon-x-vs-lbs-27b.md)\n- [Carbon-X vs LFM2.5-2.6B](https://www.anchorterminal.com/compare/carbon-x-vs-lfm2-5-2-6b.md)\n- [Carbon-X vs Ling-3.0-tiny](https://www.anchorterminal.com/compare/carbon-x-vs-ling-3-0-tiny.md)\n- [Carbon-X vs MiMo-V2.6 Distill Qwen 9B](https://www.anchorterminal.com/compare/carbon-x-vs-mimo-v2-6-distill-qwen-9b.md)\n- [Carbon-X vs MiniCPM-o 4.5](https://www.anchorterminal.com/compare/carbon-x-vs-minicpm-o-4-5.md)\n- [Carbon-X vs MiniCPM5-2B](https://www.anchorterminal.com/compare/carbon-x-vs-minicpm5-2b.md)\n- [Carbon-X vs MiniMax-M2.5](https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-5.md)\n- [Carbon-X vs MiniMax-M2.7](https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m2-7.md)\n- [Carbon-X vs MiniMax-M3.1-Flash](https://www.anchorterminal.com/compare/carbon-x-vs-minimax-m3-1-flash.md)\n- [Carbon-X vs Muse Glimmer 30B](https://www.anchorterminal.com/compare/carbon-x-vs-muse-glimmer-30b.md)\n- [Carbon-X vs Nanbeige4.3-33B](https://www.anchorterminal.com/compare/carbon-x-vs-nanbeige-4-3-33b.md)\n- [Carbon-X vs NVIDIA Nemotron 3.5 Bolt E4B 4GB](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-bolt-e4b-4gb.md)\n- [Carbon-X vs Nemotron 3.5 Lightning 30B A3B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-5-lightning-30b-a3b.md)\n- [Carbon-X vs Nemotron 3 Nano 30B A3B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-30b-a3b.md)\n- [Carbon-X vs Nemotron 3 Nano 4B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-4b.md)\n- [Carbon-X vs Nemotron 3 Nano Omni 30B A3B Reasoning](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-nano-omni-30b-a3b-reasoning.md)\n- [Carbon-X vs Nemotron 3 Super 120B A12B](https://www.anchorterminal.com/compare/carbon-x-vs-nemotron-3-super-120b-a12b.md)\n- [Carbon-X vs Nemotron 3 Ultra 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